CoChat
Sign Up
Cited by 146Sexual function and dysfunction studiesHormonal and reproductive studiesUrological Disorders and Treatments

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Lack of sexual activity from erectile dysfunction is associated with a reversible reduction in serum testosterone

Open access
Jannini, Emmanuele A., Screponi, Emiliano, Carosa, Eleonora, Pepe, Mario, Lo Giudice, Francesco, Trimarchi, Francesco, Benvenga, Salvatore·1999·International Journal of Andrology
DOI 10.1046/j.1365-2605.1999.00196.x
Open this paper in CoChat — free accountOpen PDF

Abstract

The role of androgenic hormones in human sexuality, in the mechanism of erection and in the pathogenesis of impotence is under debate. While the use of testosterone is common in the clinical therapy of male erectile dysfunction, hypogonadism is a rare cause of impotence. We evaluated serum testosterone levels in men with erectile dysfunction resulting either from organic or non-organic causes before and after non-hormonal impotence therapy. Eighty-three consecutive cases of impotence (70% organic, 30% non-organic, vascular aetiology being the most frequent) were subjected to hormonal screening before and after various psychological, medical (prostaglandin E1, yohimbine) or mechanical therapies (vascular surgery, penile prostheses, vacuum devices). Thirty age-matched healthy men served as a control group. Compared to controls, patients with impotence resulting from both organic and non-organic causes showed reduced serum levels of both total testosterone (11.1 +/- 2.4 vs. 17.7 +/- 5.5 nmol/L) and free testosterone (56.2 +/- 22.9 vs. 79.4 +/- 27.0 pmol/L) (both p < 0.001). Irrespective of the different aetiologies and of the various impotence therapies, a dramatic increase in serum total and free testosterone levels (15.6 +/- 4.2 nmol/L and 73.8 +/- 22.5 pmol/L, respectively) was observed in patients who achieved normal sexual activity 3 months after commencing therapy (p < 0.001). On the contrary, serum testosterone levels did not change in patients in whom therapies were ineffective. Since the pre-therapy low testosterone levels were independent of the aetiology of impotence, we hypothesize that this hormonal pattern is related to the loss of sexual activity, as demonstrated by its normalization with the resumption of coital activity after different therapies. The corollary is that sexual activity may feed itself throughout the increase in testosterone levels.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1046/j.1365-2605.1999.00196.x

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 40 references

Research works printed but not linked: 5

  1. 10.1210/jc.75.6.1503 · DOI · Paper page
  2. 10.1210/jc.79.2.561 · DOI
  3. 10.1210/jc.80.7.1985 · DOI
  4. Levine F. J., 1990, Vascular reconstructive surgery in the management of erectile dysfunction, International Journal of Impotence Research, 2, 59
  5. Lue T. F.(1992)Male sexual dysfunction. In:Smith’s General Urology(Eds E. A. Tanagho J. W. McAninch) pp. 696–713. Prentice Hall International London.

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Jannini, E. A., Screponi, E., Carosa, E., Pepe, M., Lo Giudice, F., Trimarchi, F., & Benvenga, S.
Affiliations
  • University of L'Aquila (IT)
  • Sapienza University of Rome (IT)
  • University of Messina (IT)
Corresponding author
Jannini, Emmanuele A.
ORCID
Venue
International Journal of Andrology
Publisher
Wiley
Published
1999-12
Volume
22
Issue
6
Pages
385-392
ISSN
  • 0105-6263 (ISSN-L)
  • 1365-2605
DOI
10.1046/j.1365-2605.1999.00196.x
OpenAlex
W2057426299
Cited by
146
References
40
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 9 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 7
FWCI
2.38
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 754 d)
Locations
  • International Journal of Andrology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Chiba University
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Keywords
erectile dysfunction, serum testosterone, free testosterone, sexual activity, hypogonadism, testosterone replacement therapy, prostaglandin E1, yohimbine, penile prosthesis, vacuum systems, vascular impotence, psychological impotence, androgens
MeSH terms
Adolescent, Adult, Aged, Humans, Erectile Dysfunction, Male, Middle Aged, Prospective Studies, Sexual Behavior, Testosterone, Matched-Pair Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review