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Cited by 80Hormonal and reproductive studiesMenopause: Health Impacts and TreatmentsAdrenal Hormones and Disorders

Androgens and the ageing male

Juul, A.·2002·Human Reproduction Update
DOI 10.1093/humupd/8.5.423
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Abstract

Hypogonadal men share a variety of signs and symptoms such as decreased muscle mass, osteopoenia, increased fat mass, fatigue, decreased libido and cognitive dysfunctions. Controlled trials have demonstrated favourable effects of androgen substitution therapy on these signs and symptoms in men with severe primary or secondary hypogonadism. Thus, androgen substitution therapy is warranted in men with true hypogonadism at all ages. Symptoms experienced by otherwise healthy ageing males are non-specific and vague, although some may be similar to symptoms of hypogonadism. Therefore, the term 'andropause' has been suggested. However, testosterone levels show no or only modest variation with age in men; with large prospective studies suggesting a maximal decline of total testosterone of 1.6% per year. Thus, in contrast to the sudden arrest of gonadal activity in females around menopause, men do not have an andropause. As large placebo-controlled studies of androgen treatment in elderly males are lacking, proper risk assessment of adverse effects such as prostate cancer following testosterone treatment in elderly males is completely lacking. In the future, testosterone therapy may prove beneficial in some elderly males with low-normal testosterone levels. However, at this point in time, widespread use of testosterone in an elderly male population outside controlled clinical trials seems inappropriate.

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Crossref · 10.1093/humupd/8.5.423

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112 of 112 references verified0 citation errors · 0 not checkable

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  • The slow decrease in testosterone observed in adulthood may play a role in the reversal of adolescent chronotype in men.

    “These data suggests that the slow decrease in testosterone observed in adulthood [86] may play a role in the reversal of adolescent chronotype in men.”

    From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [86]

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Authors
Juul, A.
Affiliations
University of Copenhagen (DK)
Corresponding author
Juul, A.
ORCID
Juul, A.
Venue
Human Reproduction Update
Publisher
Oxford University Press (OUP)
Published
2002-09-01
Volume
8
Issue
5
Pages
423-433
ISSN
  • 1355-4786 (ISSN-L)
  • 1460-2369
DOI
10.1093/humupd/8.5.423
OpenAlex
W2102384405
Cited by
80
References
112
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 5 · 2020: 5 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 7
FWCI
3.46
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction Update (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
testosterone replacement therapy, male hypogonadism, older men, andropause, prostate cancer risk, elderly man
MeSH terms
Aging, Humans, Hypogonadism, Male, Gonadal Steroid Hormones, Testosterone

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