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Cited by 146Sexual function and dysfunction studiesHormonal and reproductive studiesUrological Disorders and Treatments

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Lack of sexual activity from erectile dysfunction is associated with a reversible reduction in serum testosterone

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Jannini, Emmanuele A., Screponi, Emiliano, Carosa, Eleonora, Pepe, Mario, Lo Giudice, Francesco, Trimarchi, Francesco, Benvenga, Salvatore·1999·International Journal of Andrology
DOI 10.1046/j.1365-2605.1999.00196.x
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Abstract

The role of androgenic hormones in human sexuality, in the mechanism of erection and in the pathogenesis of impotence is under debate. While the use of testosterone is common in the clinical therapy of male erectile dysfunction, hypogonadism is a rare cause of impotence. We evaluated serum testosterone levels in men with erectile dysfunction resulting either from organic or non-organic causes before and after non-hormonal impotence therapy. Eighty-three consecutive cases of impotence (70% organic, 30% non-organic, vascular aetiology being the most frequent) were subjected to hormonal screening before and after various psychological, medical (prostaglandin E1, yohimbine) or mechanical therapies (vascular surgery, penile prostheses, vacuum devices). Thirty age-matched healthy men served as a control group. Compared to controls, patients with impotence resulting from both organic and non-organic causes showed reduced serum levels of both total testosterone (11.1 +/- 2.4 vs. 17.7 +/- 5.5 nmol/L) and free testosterone (56.2 +/- 22.9 vs. 79.4 +/- 27.0 pmol/L) (both p < 0.001). Irrespective of the different aetiologies and of the various impotence therapies, a dramatic increase in serum total and free testosterone levels (15.6 +/- 4.2 nmol/L and 73.8 +/- 22.5 pmol/L, respectively) was observed in patients who achieved normal sexual activity 3 months after commencing therapy (p < 0.001). On the contrary, serum testosterone levels did not change in patients in whom therapies were ineffective. Since the pre-therapy low testosterone levels were independent of the aetiology of impotence, we hypothesize that this hormonal pattern is related to the loss of sexual activity, as demonstrated by its normalization with the resumption of coital activity after different therapies. The corollary is that sexual activity may feed itself throughout the increase in testosterone levels.

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Research works printed but not linked: 5

  1. 10.1210/jc.75.6.1503 · DOI · Paper page
  2. 10.1210/jc.79.2.561 · DOI
  3. 10.1210/jc.80.7.1985 · DOI
  4. Levine F. J., 1990, Vascular reconstructive surgery in the management of erectile dysfunction, International Journal of Impotence Research, 2, 59
  5. Lue T. F.(1992)Male sexual dysfunction. In:Smith’s General Urology(Eds E. A. Tanagho J. W. McAninch) pp. 696–713. Prentice Hall International London.

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Metadata

Authors
Jannini, E. A., Screponi, E., Carosa, E., Pepe, M., Lo Giudice, F., Trimarchi, F., & Benvenga, S.
Affiliations
  • University of L'Aquila (IT)
  • Sapienza University of Rome (IT)
  • University of Messina (IT)
Corresponding author
Jannini, Emmanuele A.
ORCID
Venue
International Journal of Andrology
Publisher
Wiley
Published
1999-12
Volume
22
Issue
6
Pages
385-392
ISSN
  • 0105-6263 (ISSN-L)
  • 1365-2605
DOI
10.1046/j.1365-2605.1999.00196.x
OpenAlex
W2057426299
Cited by
146
References
40
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 9 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 7
FWCI
2.38
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 754 d)
Locations
  • International Journal of Andrology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Chiba University
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Keywords
erectile dysfunction, serum testosterone, free testosterone, sexual activity, hypogonadism, testosterone replacement therapy, prostaglandin E1, yohimbine, penile prosthesis, vacuum systems, vascular impotence, psychological impotence, androgens
MeSH terms
Adolescent, Adult, Aged, Humans, Erectile Dysfunction, Male, Middle Aged, Prospective Studies, Sexual Behavior, Testosterone, Matched-Pair Analysis

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