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Cited by 215Hormonal and reproductive studiesSexual function and dysfunction studiesHypothalamic control of reproductive hormones

Sexual function does not change when serum testosterone levels are pharmacologically varied within the normal male range

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Buena, Felicitas, Swerdloff, Ronald S., Steiner, Barbara S., Lutchmansingh, Preetam, Peterson, Margaret A., Pandian, Murugan R., Galmarini, Mirta, Bhasin, Shalender·1993·Fertility and Sterility
DOI 10.1016/s0015-0282(16)55938-x
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Abstract

Objective To examine the relationship between serum T levels and sexual function when T levels are varied in the normal male range by pharmacological means. Two groups of healthy men were treated with a depot form of GnRH agonist leuprolide acetate (Lupron depot; TAP Pharmaceuticals, Chicago, IL) on days 1 and 31 to suppress endogenous T production and either 4 (n = 6) or 8 (n = 5) mg/d T replacement by a sustained release, long-acting T microcapsule formulation on day 1.Outcome measures Sexual function was evaluated by daily logs of sexual activity and electroencephalogram-coupled nocturnal penile tumescence recording before and after 9 weeks of treatment.Results Serum T levels in 4 and 8 mg/d groups were at low and high ends of the normal male range, respectively (10.5 +/- 1.7 versus 26.5 +/- 3.4 nmol/L). The number and duration of rapid eye movement (REM) periods, latency to REM sleep, erections/REM period, magnitude, and duration of tumescence were not significantly different between the 4 and 8 mg groups. Sexual logs also did not show significant differences in overall scores or in subcategories of intensity of sexual feelings (libido) and sexual activity between the two doses.Conclusions These data indicate that erectile function and sexual activity and feelings are restored by relatively low T levels. These data may help explain why some partially hypogonadal men continue to have normal sexual function and the absence of good correlation between serum T levels in the normal range and sexual function.

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  • Varying testosterone levels within the normal range produces no difference in sexual activity, sexual interest or NPT, although rigidity of NPT was not measured.

    “They found no difference in sexual activity, sexual interest or NPT, although the rigidity of NPT was not measured.”

    From The endocrinology of sexual arousal (2005) · cites this paper as Buena et al. (1993)

  • In healthy younger men whose endogenous testosterone was fully suppressed, sexual function completely recovered when circulating testosterone was restored to the physiological male range by administration of exogenous testosterone.

    “In healthy younger men whose endogenous testosterone was fully suppressed, sexual function completely recovered when circulating testosterone was restored to the physiological male range by administration of exogenous testosterone (67).”

    From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [67]

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Authors
Buena, F., Swerdloff, R. S., Steiner, B. S., Lutchmansingh, P., Peterson, M. A., Pandian, M. R., Galmarini, M., & Bhasin, S.
Affiliations
Los Angeles Medical Center (US)
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
1993-05
Volume
59
Issue
5
Pages
1118-1123
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/s0015-0282(16)55938-x
OpenAlex
W71919669
Cited by
215
References
24
Citations by year
2024: 1 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 5 · 2013: 3 · 2012: 5
FWCI
2.11
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Center for Research Resources (M01RR000425, M01-RR00425)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
testosterone, sexual function, erectile function, nocturnal penile tumescence, leuprolide, GnRH agonist, testosterone replacement therapy, hypogonadism, sexual desire, REM sleep, healthy men
MeSH terms
Adult, Delayed-Action Preparations, Dose-Response Relationship, Drug, Electroencephalography, Humans, Male, Middle Aged, Penile Erection, Reference Values, Sexual Behavior, Sleep, REM, Testosterone, Leuprolide

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