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Cited by 134Nail Diseases and TreatmentsAntimicrobial agents and applicationsDermatology and Skin Diseases

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Antimicrobial effect of acidified nitrite on dermatophyte fungi candida and bacterial skin pathogens

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Weller, R., Price, R.J., Ormerod, A.D., Benjamin, N., Leifert, C.·2001·Journal of Applied Microbiology
DOI 10.1046/j.1365-2672.2001.01291.x
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Abstract

AIMS: Nitric oxide is generated from sweat nitrite in the acidic environment of the skin surface and is thought to contribute to protection against infection. This study examined the sensitivity of Trichophyton mentagrophytes, T. rubrum, Candida albicans, Streptococcus pyogenes, Staphylococcus aureus and Propionibacterium acnes to acidified nitrite. METHODS AND RESULTS: Organisms were cultured in varying concentrations of nitrite and pH for different lengths of time, before being transferred to recovery medium. With the exception of Strep. pyogenes, addition of nitrite increased the antimicrobial activity of acid solutions against all organisms tested. The rank order of sensitivity was: C. albicans < T. rubrum < T. mentagrophytes < Staph. aureus < P. acnes, with P. acnes being most sensitive. CONCLUSION: This work has shown that acidified nitrite is microbiocidal to common cutaneous pathogens. The concentrations of nitrite required to kill pathogenic fungi and bacteria in in vitro assays were higher than the concentrations of nitrite measured in sweat. However, additional co-factors in vivo and in sweat may potentiate the effect of acidified nitrite. SIGNIFICANCE AND IMPACT OF THE STUDY: Pharmacological preparations of acidified nitrite are novel antimicrobial agents. These data suggest skin organisms which may be sensitive to this treatment.

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Crossref · 10.1046/j.1365-2672.2001.01291.x

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  1. Calderon R.A., 1987, Immunology, 61, 283

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Metadata

Authors
Weller, R., Price, R. J., Ormerod, A. D., Benjamin, N., & Leifert, C.
Affiliations
  • Aberdeen Royal Infirmary (GB)
  • St Bartholomew's Hospital (GB)
  • Newcastle University (GB)
ORCID
Venue
Journal of Applied Microbiology
Publisher
Oxford University Press (OUP)
Published
2001-04
Volume
90
Issue
4
Pages
648-652
ISSN
  • 1364-5072 (ISSN-L)
  • 1365-2672
DOI
10.1046/j.1365-2672.2001.01291.x
OpenAlex
W1981038001
Cited by
134
References
28
Citations by year
2026: 3 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 8 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 8 · 2015: 7 · 2014: 5 · 2013: 10 · 2012: 6
FWCI
2.80
Type
journal article
Language
en
Open access
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 5266 d)
Locations
  • Journal of Applied Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • Newcastle University ePrints (Newcastle Univesity)
Topics
  • Health Sciences › Medicine › Dermatology › Nail Diseases and Treatments
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
nitric oxide, dermatophytes, Trichophyton mentagrophytes, Trichophyton rubrum, Candida albicans, Streptococcus pyogenes, Staphylococcus aureus, Propionibacterium acnes, skin pathogens, antimicrobial activity, sweat, pH, skin infections
MeSH terms
Acids, Candida, Humans, Microbial Sensitivity Tests, Nitrites, Propionibacterium acnes, Skin Diseases, Staphylococcus aureus, Streptococcus pyogenes

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