The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Antimicrobial effect of acidified nitrite on dermatophyte fungi candida and bacterial skin pathogens
Open accessAbstract
AIMS: Nitric oxide is generated from sweat nitrite in the acidic environment of the skin surface and is thought to contribute to protection against infection. This study examined the sensitivity of Trichophyton mentagrophytes, T. rubrum, Candida albicans, Streptococcus pyogenes, Staphylococcus aureus and Propionibacterium acnes to acidified nitrite. METHODS AND RESULTS: Organisms were cultured in varying concentrations of nitrite and pH for different lengths of time, before being transferred to recovery medium. With the exception of Strep. pyogenes, addition of nitrite increased the antimicrobial activity of acid solutions against all organisms tested. The rank order of sensitivity was: C. albicans < T. rubrum < T. mentagrophytes < Staph. aureus < P. acnes, with P. acnes being most sensitive. CONCLUSION: This work has shown that acidified nitrite is microbiocidal to common cutaneous pathogens. The concentrations of nitrite required to kill pathogenic fungi and bacteria in in vitro assays were higher than the concentrations of nitrite measured in sweat. However, additional co-factors in vivo and in sweat may potentiate the effect of acidified nitrite. SIGNIFICANCE AND IMPACT OF THE STUDY: Pharmacological preparations of acidified nitrite are novel antimicrobial agents. These data suggest skin organisms which may be sensitive to this treatment.
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Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704 · cited 2×
“INTRODUCTION The function of nitric oxide (NO) in the modulation of vascular tone, neurotransmission and immune function has been extensively documented (Vallance and Collier 1994) since its ®rst description as an effector molecule in man in 1987 (Palmer et al. 1987).”
BackgroundNathan, C., & Shiloh, M. U. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.8841 · Cited by 1,469
Fang, F. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119473 · Cited by 1,139
Disease concomitance in psoriasis
Henseler, T., & Christophers, E. (1995) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(95)91336-x · Cited by 680
Benjamin, N., O'Driscoll, F., Dougall, H., Duncan, C., Smith, L., Golden, M., & McKenzie, H. (1994) · Nature · doi:10.1038/368502a0 · Cited by 665
Self-citationMechanisms of nitric oxide-related antimicrobial activity
Fang, F. C. (1997) · Journal of Clinical Investigation · Cited by 446
Nunoshiba, T., deRojas-Walker, T., Wishnok, J. S., Tannenbaum, S. R., & Demple, B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.9993 · Cited by 311
Dykhuizen, R. S., Frazer, R., Duncan, C., Smith, C. C., Golden, M., Benjamin, N., & Leifert, C. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.6.1422 · Cited by 239
Self-citationReactive nitrogen intermediates and antimicrobial activity: Role of nitrite
Klebanoff, S. J. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90084-8 · Cited by 192
Nitric Oxide Is Generated on the Skin Surface by Reduction of Sweat Nitrate
Weller, R., Pattullo, S., Smith, L. M., Golden, M., Ormerod, A. D., & Benjamin, N. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12363167 · Cited by 174
Self-citationDuncan, C., Li, H., Dykhuizen, R., Frazer, R., Johnston, P., MacKnight, G., Smith, L., Lamza, K., McKenzie, H., Batt, L., et al. (1997) · Comparative Biochemistry and Physiology Part A: Physiology · doi:10.1016/s0300-9629(97)00023-6 · Cited by 147
Self-citationFactors Affecting the Bacteriostatic Action of Sodium Nitrite
Castellani, A. G., & Niven, C. F. (1955) · Applied Microbiology · doi:10.1128/am.3.3.154-159.1955 · Cited by 138
Fortnightly Review Biology and clinical relevance of nitric oxide
Vallance, P. J., & Collier, J. (1994) · BMJ · doi:10.1136/bmj.309.6952.453 · Cited by 137
Eady, E. A. (1998) · Dermatology · doi:10.1159/000017869 · Cited by 128
Resistance to nitric oxide in Mycobacterium avium complex and its implication in pathogenesis
Doi, T., Ando, M., Akaike, T., Suga, M., Sato, K., & Maeda, H. (1993) · Infection and Immunity · doi:10.1128/iai.61.5.1980-1989.1993 · Cited by 101
O’Brien, L. M., Carmichael, J., Lowrie, D. B., & Andrew, P. W. (1994) · Infection and Immunity · doi:10.1128/iai.62.11.5187-5190.1994 · Cited by 98
Inhibitors of Nitric Oxide Synthase in Human Skin
Goldsmith, P. C., Leslie, T. A., Hayes, N. A., Levell, N. J., Dowd, P. M., & Foreman, J. C. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12328204 · Cited by 94
Nitric oxide and antimicrobial activity of reactive oxygen intermediates
Marcinkiewicz, J. (1997) · Immunopharmacology · doi:10.1016/s0162-3109(96)00168-3 · Cited by 80
A randomized trial of acidified nitrite cream in the treatment of tinea pedis
Weller, R., Ormerod, A. D., Hobson, R. P., & Benjamin, N. J. (1998) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(98)70117-3 · Cited by 74
Self-citationOrmerod, A. D., White, M. I., Shah, S. S., & Benjamin, N. (1999) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1999.03204.x · Cited by 72
Self-citationFactors Affecting the Bacteriostatic Action of Sodium Nitrite1
Castellani, A. G., & Niven, C. F. (1955) · Applied Microbiology · doi:10.1128/aem.3.3.154-159.1955 · Cited by 72
Wound licking and nitric oxide
Benjamin, N., Pattullo, S., Weller, R., Smith, L. M., & Ormerod, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(05)63002-4 · Cited by 50
Self-citationDippel, E., Mayer, B., Schönfelder, G., Czarnetzki, B. M., & Paus, R. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12391865 · Cited by 41
Increased expression of inducihie nitric oxide (NO) synthase
Weller, R., & Ormerod, A. D. (1997) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1997.tb08768.x · Cited by 27
Self-citationEffect of therapeutic concentrations of nitric oxide on bacterial growth in vitro
Hoehn, T., Hüebner, J., Paboura, E., Krause, M., & Leititis, J. U. (1998) · Critical Care Medicine · doi:10.1097/00003246-199811000-00028 · Cited by 27
Calderón, R. A., & Shennan, G. I. (1987) · PubMed · Cited by 23
Nameda, Y., Miyoshi, H., Tsuchiya, K., Nakaya, Y., & Arase, S. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12343014 · Cited by 18
Nitric oxide release accounts for the reduced incidence of cutaneousinfections in psoriasis
Weller, R., Dykhuizen, R. S., Leifert, C., & Ormerod, A. D. (1997) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(97)70307-4 · Cited by 13
Self-citation
Research works printed but not linked: 1
- Calderon R.A., 1987, Immunology, 61, 283
Cited by
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Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739
Huh, A. J., & Kwon, Y. J. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.07.002 · Cited by 1,920
Nitrate, bacteria and human health
Lundberg, J. O., Weitzberg, E., Cole, J. A., & Benjamin, N. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro929 · Cited by 739
Self-citationSkin pH: from basic science to basic skin care
Ali, S., & Yosipovitch, G. (2013) · Acta Dermato Venereologica · doi:10.2340/00015555-1531 · Cited by 690
The potential of nitric oxide releasing therapies as antimicrobial agents
Schairer, D. O., Chouake, J. S., Nosanchuk, J. D., & Friedman, A. (2012) · Virulence · doi:10.4161/viru.20328 · Cited by 577
Metadata
- Authors
- Weller, R., Price, R. J., Ormerod, A. D., Benjamin, N., & Leifert, C.
- Affiliations
- Aberdeen Royal Infirmary (GB)
- St Bartholomew's Hospital (GB)
- Newcastle University (GB)
- Venue
- Journal of Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-04
- Volume
- 90
- Issue
- 4
- Pages
- 648-652
- ISSN
- 1364-5072 (ISSN-L)
- 1365-2672
- OpenAlex
- W1981038001
- Cited by
- 134
- References
- 28
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 6 · 2021: 8 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 8 · 2015: 7 · 2014: 5 · 2013: 10 · 2012: 6
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Journal of Applied Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Dermatology › Nail Diseases and Treatments
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- nitric oxide, dermatophytes, Trichophyton mentagrophytes, Trichophyton rubrum, Candida albicans, Streptococcus pyogenes, Staphylococcus aureus, Propionibacterium acnes, skin pathogens, antimicrobial activity, sweat, pH, skin infections
- MeSH terms
- Acids, Candida, Humans, Microbial Sensitivity Tests, Nitrites, Propionibacterium acnes, Skin Diseases, Staphylococcus aureus, Streptococcus pyogenes
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