CoChat
Sign Up
Cited by 164Obstructive Sleep Apnea ResearchNeuroscience of respiration and sleepHormonal and reproductive studies

The DOI matches its Crossref record; 38 of the 40 references it cites were found in a registry or an index.

Endocrine effects of nasal continuous positive airway pressure in male patients with obstructive sleep apnoea

Open access
Meston, N., Davies, R. J. O., Mullins, R., Jenkinson, C., Wass, J. A. H., Stradling, J. R.·2003·Journal of Internal Medicine
DOI 10.1046/j.1365-2796.2003.01212.x
Open this paper in CoChat — free accountOpen PDF

Abstract

Abstract. Meston N, Davies RJO, Mullins R, Jenkinson C, Wass JAH, Stradling JR (University of Oxford, John Radcliffe Hospital; Oxford Centre for Respiratory Medicine and University of Oxford, Churchill Hospital; Health Services Research Unit; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Infirmary; Oxford, UK). Endocrine effects of nasal continuous positive airway pressure in male patients with obstructive sleep apnoea. J Intern Med 2003; 254: 447–454. Objective. Obstructive sleep apnoea (OSA) is a relatively common condition producing disabling somnolence and profound physiological responses to hypoxaemic episodes during sleep, including significant oscillations in blood pressure. This study aimed to provide controlled data on the interaction between OSA and endocrine axes to establish whether overrepresentation of pathology such as hypertension and hypogonadism in OSA subjects might have an endocrine basis. Design, setting and subjects. Parallel randomized sham placebo controlled 1‐month trial of nasal continuous positive airway pressure (nCPAP) in 101 male subjects with OSA presenting to a respiratory sleep clinic. Methods. Analysis of gonadotrophins, testosterone, sex hormone binding protein (SHBG), prolactin, cortisol, thyroid stimulating hormone (TSH), free thyroxine (free T4), insulin‐like growth factor‐1 (IGF‐1), renin and aldosterone were performed at baseline and after 1 month's active or placebo nCPAP intervention. Quality of life questionnaire scoring was also recorded over the same time period. Results. Testosterone and SHBG showed significant negative correlations with baseline OSA severity. Active treatment of OSA produced SHBG elevation and TSH reduction (P ≤ 0.03). Both groups showed an increase in aldosterone (P < 0.001) and IGF‐1 (P ≤ 0.03), associated with a large improvement in subjective quality of life scoring. Conclusions. These findings demonstrate significant changes in endocrine axes not previously reported in a placebo‐controlled trial. OSA is a recognized reversible cause of testosterone reduction; SHBG suppression correlating to baseline OSA severity supports a diagnosis of secondary hypogonadism. Significant rises in aldosterone and IGF‐1 on treatment coincide with increased physical activity and an improved quality of life score.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1046/j.1365-2796.2003.01212.x

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 3

  1. Stewart DA, 1989, Neuroendocrine changes in sleep apnea are not related to a pituitary defect, Sleep Res, 18, 308
  2. Rapoport D, 1989, Obstructive sleep apnea (OSA) alters ultradian rhythm of ACTH secretion, Am Rev Respir Dis, 139, A80
  3. Saini J, 1991, Horm Metab Res, 375

Cited by

Sorted by citations

See all 164

Related

See all

Metadata

Authors
Meston, N., Davies, R. J. O., Mullins, R., Jenkinson, C., Wass, J. A. H., & Stradling, J. R.
Affiliations
  • John Radcliffe Hospital (GB)
  • Churchill Hospital (GB)
  • University of Oxford (GB)
Corresponding author
Meston, N.
ORCID
Venue
Journal of Internal Medicine
Publisher
Wiley
Published
2003-10-09
Volume
254
Issue
5
Pages
447-454
ISSN
  • 0954-6820 (ISSN-L)
  • 1365-2796
DOI
10.1046/j.1365-2796.2003.01212.x
OpenAlex
W2002557448
Cited by
163
References
40
Citations by year
2026: 4 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 7 · 2020: 3 · 2019: 9 · 2018: 8 · 2017: 5 · 2016: 11 · 2015: 8 · 2014: 19 · 2013: 12 · 2012: 6
FWCI
2.77
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
obstructive sleep apnea, nasal continuous positive airway pressure, endocrine effects, secondary hypogonadism, testosterone, sex hormone-binding globulin, aldosterone, insulin-like growth factor I, thyroid-stimulating hormone, prolactin, cortisol, quality of life, male patients
MeSH terms
Aldosterone, Hormones, Humans, Insulin-Like Growth Factor I, Male, Positive-Pressure Respiration, Quality of Life, Sex Hormone-Binding Globulin, Testosterone, Thyrotropin, Sleep Apnea, Obstructive

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review