The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Functional Cross‐Talk Between the Hypothalamic‐Pituitary‐Gonadal and ‐Adrenal Axes
Abstract
Under normal conditions, the adrenal glucocorticoids, the endproduct of the hypothalamic‐pituitary‐adrenal (HPA) axis, provide a frontline of defence against threats to homeostasis (i.e. stress). On the other hand, chronic HPA drive and glucocorticoid hypersecretion have been implicated in the pathogenesis of several forms of systemic, neurodegenerative and affective disorders. The HPA axis is subject to gonadal influence, indicated by sex differences in basal and stress HPA function and neuropathologies associated with HPA dysfunction. Functional cross‐talk between the gonadal and adrenal axes is due in large part to the interactive effects of sex steroids and glucocorticoids, explaining perhaps why several disease states linked to stress are sex‐dependent. Realizing the interactive nature by which the hypothalamic‐pituitary‐gonadal and HPA systems operate, however, has made it difficult to model how these hormones act in the brain. Manipulation of one endocrine system is not without effects on the other. Simultaneous manipulation and assessment of both endocrine systems can overcome this problem. This dual approach in the male rat reveals that testosterone can act and interact on different aspects of basal and stress HPA function. Basal adrenocorticotropic hormone (ACTH) release is regulated by testosterone‐dependent effects on arginine vasopressin synthesis, and corticosterone‐dependent effects on corticotropin‐releasing hormone (CRH) synthesis in the paraventricular nucleus (PVN) of the hypothalamus. In contrast, testosterone and corticosterone interact on stress‐induced ACTH release and drive to the PVN motor neurones. Candidate structures mediating this interaction include several testosterone‐sensitive afferents to the HPA axis, including the medial preoptic area, central and medial amygdala and bed nuclei of the stria terminalis. All of these relay homeostatic information and integrate reproductive and social behaviour. Because these modalities are affected by stress in humans, a dual systems approach holds great promise in establishing further links between the neuroendocrinology of stress and the central bases of sex‐dependent disorders, including psychiatric, cardiovascular and metabolic disease.
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In the citing paper
“Such double-inhibitory loop operates physiological functions [72,131], but under peculiar circumstances could lead to functional disorders.”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [131]
In the citing paper
“men with lower basal cortisol concentrations show larger increases in the testosterone response to social stress (tang, tang, Posner, & Gross, 2022;Viau, 2002).”
From Salivary testosterone and cortisol response in acute stress modulated by seven sessions of mindfulness meditation in young males (2024) · cites this paper as Viau, 2002
In the citing paper
“Androgens and estrogen modulate cortisol synthesis in the adrenal cortex and CRH and AVP synthesis in the hypothalamus; the latter effect is mediated by sex hormone receptors in the amygdala (Viau, 2002; Viau et al., 2005)”
From The Adaptive Calibration Model of stress responsivity (2011) · cites this paper as Viau, 2002
In the citing paper
“Cross-talk between endocrine systems can even take place at the genomic level, since androgen and glucocorticoid receptors can interact in the regulation of gene transcription (Viau, 2002)”
From The Adaptive Calibration Model of stress responsivity (2011) · cites this paper as Viau, 2002
Citations
Cites
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Antidepressants and Hypothalamic-Pituitary-Adrenocortical Regulation
HOLSBOER, F., & Barden, N. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-2-187 · Cited by 860
Rivier, C., & Rivest, S. (1991) · Biology of Reproduction · doi:10.1095/biolreprod45.4.523 · Cited by 799
Gonadal Steroid Hormone Receptors and Sex Differences in the Hypothalamo-Pituitary-Adrenal Axis
Handa, R. J., Burgess, L. H., Kerr, J. E., & O'Keefe, J. A. (1994) · Hormones and Behavior · doi:10.1006/hbeh.1994.1044 · Cited by 793
Topography of projections from amygdala to bed nuclei of the stria terminalis
Dong, H.-W., Petrovich, G. D., & Swanson, L. W. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00079-0 · Cited by 714
(2003) · Choice Reviews Online · doi:10.5860/choice.40-2774 · Cited by 705
VIAU, V., & MEANEY, M. J. (1991) · Endocrinology · doi:10.1210/endo-129-5-2503 · Cited by 666
Self-citationVasopressinergic control of pituitary adrenocorticotropin secretion comes of age
Antoni, F. A. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1004 · Cited by 636
Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system
Whitnall, M. H. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90035-q · Cited by 582
Dong, H., Petrovich, G. D., Watts, A. G., & Swanson, L. W. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1079 · Cited by 521
Cited by
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BOYCE, W. T., & ELLIS, B. J. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050145 · Cited by 2,078
The Adaptive Calibration Model of stress responsivity
Del Giudice, M., Ellis, B. J., & Shirtcliff, E. A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.007 · Cited by 1,373
Affective consciousness: core emotional feelings in animals and humans.
Panksepp, J. (2005) · Consciousness and Cognition · doi:10.1016/j.concog.2004.10.004 · Cited by 1,217
The cortisol awakening response (CAR): Facts and future directions
Fries, E., Dettenborn, L., & Kirschbaum, C. (2009) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2008.03.014 · Cited by 1,188
Korte, S. M., Koolhaas, J. M., Wingfield, J. C., & McEwen, B. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.08.009 · Cited by 1,097
Metadata
- Authors
- Viau, V.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Viau, V.
- ORCID
- Viau, V.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2002-05-29
- Volume
- 14
- Issue
- 6
- Pages
- 506-513
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W2161277545
- Cited by
- 744
- References
- 69
- Citations by year
- 2026: 18 · 2025: 27 · 2024: 31 · 2023: 31 · 2022: 29 · 2021: 30 · 2020: 24 · 2019: 30 · 2018: 39 · 2017: 39 · 2016: 43 · 2015: 48 · 2014: 35 · 2013: 44 · 2012: 46
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- hypothalamic-pituitary-gonadal axis, hypothalamic-pituitary-adrenal axis, testosterone, corticosterone, sex steroids, glucocorticoids, stress, ACTH, vasopressin, corticotropin-releasing factor, paraventricular nucleus, medial preoptic area, central amygdala, bed nucleus of the stria terminalis, sex differences
- MeSH terms
- Animals, Brain, Gonads, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Testosterone
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