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Day-time melatonin administration: Effects on core temperature and sleep onset latency
Open accessAbstract
Significant hypothermic and hypnotic effects have been reported for melatonin at a wide range of doses. It has been suggested that this decrease in core temperature (Tc) following melatonin administration may mediate the observed increase in sleepiness. To test this, melatonin was administered to young adults during the day, and the concurrent effects on Tc and sleep onset latency (SOL) were recorded. Sixteen healthy males received either a 5 mg oral formulation of melatonin or placebo at 14.00 hours. Core temperature was recorded continuously. Sleep onset latency to stage 1 (SOL1) and stage 2 (SOL2) were recorded using an hourly multiple sleep latency test (MSLT). Compared with placebo, melatonin significantly decreased Tc 1.5 h after administration for 6 h. Between 15.00 and 18.00 hours, the drop in Tc was associated with a concurrent decrease in SOL1 and SOL2. Following administration mean SOL1 and SOL2 were reduced by 40 and 25%, respectively. In this study, daytime melatonin administration produced a significant decrease in Tc with a corresponding decrease in SOL. Taken together, these data are not inconsistent with the suggestion that melatonin may facilitate sleep onset via a hypothermic effect. In addition, this study provides support for the idea that melatonin may play a role in regulating circadian and/or age-related variations in sleep/wake propensity. From a practical perspective, exogenous melatonin may be useful in the treatment of sleep disorders associated with increased nocturnal Tc.
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“A decrease in core body temperature is soporific [90].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [90]
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“[103] Reid K, Van den Heuvel C, Dawson D.”
BackgroundGooley, J. J., Chamberlain, K., Smith, K. A., Khalsa, S. B. S., Rajaratnam, S. M. W., Van Reen, E., Zeitzer, J. M., Czeisler, C. A., & Lockley, S. W. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2098 · Cited by 565
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“Absolute values for rectal temperature and the skin temperatures at each of the four sites were used to calculate mean skin temperature [21] and mean body temperature [22].”
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Self-citationKlerman, E., Zeitzer, J. M., Duffy, J. F., Khalsa, S. B. S., & Czeisler, C. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.7.7659 · Cited by 22
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Self-citationRoach, G. D., Reid, K. J., Ferguson, S. A., & Dawson, D. E. (2006) · Journal of Circadian Rhythms · doi:10.1186/1740-3391-4-8 · Cited by 10
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Burgess, H. J., & Dawson, D. E. (1999) · The Journal of the British Menopause Society · doi:10.1177/136218079900500310 · Cited by 1
Self-citationNutrition, Pharmacology, and Psychology in Sports
(2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-3143-7.00008-7 · Cited by 1
Dollish, H. K., Kennedy, K. E. R., Grandner, M. A., & Fernandez, F. (2023) · Healthy ageing and longevity · doi:10.1007/978-3-031-22468-3_25 · Cited by 1
Melatonin Beyond Sleep, Part I: An Overview
Lucius, K. (2022) · Integrative and Complementary Therapies · doi:10.1089/ict.2022.29025.klu · Cited by 1
“…assessed daytime administration of melatonin (although past studies have indeed examined the effects of daytime administration, and find it may induce a subjective sense of daytime sleepiness, a mild residual effect on psychomotor performance, or a mild decrease in core body temperature 5,6 ).”
Melatonin in Sleep-Wake Regulation
Zee, P. C., & Reid, K. J. (2010) · Medical psychiatry · doi:10.3109/9781420080803.035 · Cited by 2
Self-citationHajak, G., & Rüther, E. (2008) · Springer eBooks · doi:10.1007/978-3-540-33129-2_66 · Cited by 1
The use of actresses in midwifery education.
Baker, K., Garrett, E. G., & Kirkham, M. (1997) · PubMed · Cited by 1
Melatonin Efficacy to Treat Circadian Alterations of Sleep in Alzheimer’s Disease
Cardinali, D. P., Furio, A. M., Brusco, L. I., & Liberczuk, C. (2006) · Springer eBooks · doi:10.1007/0-387-27682-3_11
Zhang, F., Cheng, Y. H., Wan, N., et al. (2015) · Biomedical Chromatography · doi:10.1002/bmc.3440
Acción de la melatonina en el proceso de envejecimiento
López, B. D. (2001) · Revista Española de Geriatría y Gerontología · doi:10.1016/s0211-139x(01)74733-6
Swami, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13814-0.00016-8
Melatoniinin vaikutuksia hormonipitoisuuksiin ja suorituskykyyn voimaharjoituksen yhteydessä
Vähälummukka, M. (2005) · Jyväskylä University Digital Archive (University of Jyväskylä)
Safety and efficacy of ZOLSOMA tablets in patients with insomnia
Karia, S., Gupta, M., Dixit, M., Deepak, C., Shah, N., Verma, P., Watve, V. G., Shekhar, K. C., Amme, S., & Chaturvedi, H. (2026) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20261342
Metadata
- Authors
- REID, K., VAN DEN HEUVEL, C., & DAWSON, D.
- Affiliations
- The University of Adelaide (AU)
- University of South Australia (AU)
- Corresponding author
- REID, KATHRYN
- Venue
- Journal of Sleep Research
- Publisher
- Wiley
- Published
- 1996-09
- Volume
- 5
- Issue
- 3
- Pages
- 150-154
- ISSN
- 0962-1105 (ISSN-L)
- 1365-2869
- OpenAlex
- W2061723056
- Cited by
- 99
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 1 · 2019: 3 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Sleep Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- melatonin, core body temperature, sleep latency, hypothermic effect, hypnotic effects, sleepiness, circadian rhythm, sleep disorders, multiple sleep latency test
- MeSH terms
- Adult, Body Temperature, Electroencephalography, Humans, Male, Melatonin, Sleep, Sleep Stages
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