The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria
Open accessAbstract
Pili of Neisseria gonorrhoeae and Neisseria meningitidis mediate binding of the bacteria to human cell‐surface receptors. We found that purified pili bound to a 55‐ to 60‐kDa doublet band on SDS–PAGE of separated human epithelial cell extracts. This is a migration pattern typical of membrane cofactor protein (MCP or CD46). MCP is a widely distributed human complement regulatory protein. Attachment of the bacteria to epithelial cells was blocked by polyclonal and monoclonal antibodies directed against MCP, suggesting that this complement regulator is a receptor for piliated Neisseria. We proved this hypothesis by demonstrating that piliated, but not non‐piliated, gonococci bound to CHO cells transfected with human MCP‐cDNA. We also demonstrated a direct interaction between purified recombinant MCP and piliated Neisseria. Finally, recombinant MCP protein produced in E. coli inhibited attachment of the bacteria to target cells. Taken together, our data show that MCP is a human cell‐surface receptor for piliated pathogenic Neisseria.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
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The human CD46 molecule is a receptor for measles virus (Edmonston strain)
Dörig, R. E., Marcil, A., Chopra, A., & Richardson, C. D. (1993) · Cell · doi:10.1016/0092-8674(93)80071-l · Cited by 1,033
Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus
Naniche, D., Varior-Krishnan, G., Cervoni, F., Wild, T. F., Rossi, B., Rabourdin-Combe, C., & Gerlier, D. (1993) · Journal of Virology · doi:10.1128/jvi.67.10.6025-6032.1993 · Cited by 853
Infectious diseases associated with complement deficiencies
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Self-citationSTUDIES ON GONOCOCCUS INFECTION
Swanson, J. (1973) · The Journal of Experimental Medicine · doi:10.1084/jem.137.3.571 · Cited by 577
Control of the Complement System
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Self-citationNeisseria PilC protein identified as type-4 pilus tip-located adhesin
Rudel, T., Scheuerpflug, I., & Meyer, T. F. (1995) · Nature · doi:10.1038/373357a0 · Cited by 322
Phase variation of gonococcal pili by frameshift mutation in pilC, a novel gene for pilus assembly.
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Cited by
Complement and its role in innate and adaptive immune responses
Dunkelberger, J. R., & Song, W.-C. (2010) · Cell Research · doi:10.1038/cr.2009.139 · Cited by 1,932
Bacterial Adhesion and Entry into Host Cells
Pizarro-Cerdá, J., & Cossart, P. (2006) · Cell · doi:10.1016/j.cell.2006.02.012 · Cited by 977
“In the case of Neisseria spp., PilC-mediated adhesion to host cells via recognition of the complement regulator CD46 has been reported (Kallstrom et al., 1997), but recent studies suggest that the PilC ligand is a still undefined protein (Kirchner and Meyer, 2005).”
CD46 Is a Cellular Receptor for Human Herpesvirus 6
Santoro, F., Kennedy, P. E., Locatelli, G., Malnati, M. S., Berger, E. A., & Lusso, P. (1999) · Cell · doi:10.1016/s0092-8674(00)81678-5 · Cited by 522
Dando, S. J., Mackay-Sim, A., Norton, R., Currie, B. J., St. John, J. A., Ekberg, J. A. K., Batzloff, M., Ulett, G. C., & Beacham, I. R. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00118-13 · Cited by 428
Neisseria meningitidis: an overview of the carriage state
Yazdankhah, S. P., & Caugant, D. A. (2004) · Journal of Medical Microbiology · doi:10.1099/jmm.0.45529-0 · Cited by 379
Metadata
- Authors
- Källström, H., Liszewski, M. K., Atkinson, J. P., & Jonsson, A.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1997-08
- Volume
- 25
- Issue
- 4
- Pages
- 639-647
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2040064814
- Cited by
- 358
- References
- 35
- FWCI
- 12.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria. https://app.cochat.ai/papers/10.1046/j.1365-2958.1997.4841857.x
- The paper
- Källström, H., Liszewski, M. K., Atkinson, J. P., & Jonsson, A. (1997). Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria. Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.1997.4841857.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
