The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Roles in dimerization and blue light photoresponse of the PAS and LOV domains of Neurospora crassa white collar proteins
Open accessAbstract
The genes coding for white collar‐1 and white collar‐2 (wc‐1 and wc‐2 ) have been isolated previously, and their products characterized as Zn‐finger transcription factors involved in the control of blue light‐induced genes. Here, we show that the PAS dimerization domains present in both proteins enable the WC‐1 and WC‐2 proteins to dimerize in vitro. Homodimers and heterodimers are formed between the white collar (WC) proteins. A computer analysis of WC‐1 reveals a second domain, called LOV, also identified in NPH1, a putative blue light photoreceptor in plants and conserved in redox‐sensitive proteins and in the phytochromes. The WC‐1 LOV domain does not dimerize with canonical PAS domains, but it is able to self‐dimerize. The isolation of three blind wc‐1 strains, each with a single amino acid substitution only in the LOV domain, reveals that this region is essential for blue light responses in Neurospora. The demonstration that the WC‐1 proteins in these LOV mutants are still able to self‐dimerize suggests that this domain plays an additional role, essential in blue light signal transduction.
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Cites
Circadian oscillation of a mammalian homologue of the Drosophila period gene
Tei, H., Okamura, H., Shigeyoshi, Y., Fukuhara, C., Ozawa, R., Hirose, M., & Sakaki, Y. (1997) · Nature · doi:10.1038/39086 · Cited by 792
Identification of a Novel Domain in the Aryl Hydrocarbon Receptor Required for DNA Binding
Fukunaga, B. N., & Hankinson, O. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.7.3743 · Cited by 91
Cited by
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900
PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light
Taylor, B. L., & Zhulin, I. B. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.479-506.1999 · Cited by 1,632
Aryl hydrocarbon receptors: diversity and evolution
Hahn, M. E. (2002) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(02)00070-4 · Cited by 642
White Collar-1, a Circadian Blue Light Photoreceptor, Binding to the frequency Promoter
Froehlich, A. C., Liu, Y., Loros, J. J., & Dunlap, J. C. (2002) · Science · doi:10.1126/science.1073681 · Cited by 520
van der Horst, M. A., & Hellingwerf, K. J. (2004) · Accounts of Chemical Research · doi:10.1021/ar020219d · Cited by 379
Metadata
- Authors
- Ballario, P., Talora, C., Galli, D., Linden, H., & Macino, G.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 1998-08
- Volume
- 29
- Issue
- 3
- Pages
- 719-729
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W1983373264
- Cited by
- 184
- References
- 2
- FWCI
- 17.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Ballario, P., Talora, C., Galli, D., Linden, H., & Macino, G. (1998). Roles in dimerization and blue light photoresponse of the PAS and LOV domains of Neurospora crassa white collar proteins. Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.1998.00955.x
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