Circadian oscillation of a mammalian homologue of the Drosophila period gene

Genomic sequencing.

Church, G. M., & Gilbert, W. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.7.1991 · Cited by 8,213 · see citing works

Clock Mutants of Drosophila melanogaster

Konopka, R. J., & Benzer, S. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.9.2112 · Cited by 2,287 · see citing works

Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat

Moore, R. Y., & Eichler, V. B. (1972) · Brain Research · doi:10.1016/0006-8993(72)90054-6 · Cited by 2,135 · see citing works

Circadian Rhythms in Drinking Behavior and Locomotor Activity of Rats Are Eliminated by Hypothalamic Lesions

Stephan, F. K., & Zucker, I. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1583 · Cited by 2,039 · see citing works

Mutagenesis and Mapping of a Mouse Gene, <i>Clock</i> , Essential for Circadian Behavior

Vitaterna, M. H., King, D. P., Chang, A.-M., Kornhauser, J. M., Lowrey, P. L., McDonald, J. D., Dove, W. F., Pinto, L. H., Turek, F. W., & Takahashi, J. S. (1994) · Science · doi:10.1126/science.8171325 · Cited by 1,632 · see citing works

Positional Cloning of the Mouse Circadian Gene

King, D. P., Zhao, Y., Sangoram, A. M., Wilsbacher, L. D., Tanaka, M., Antoch, M. P., Steeves, T. D. L., Vitaterna, M. H., Kornhauser, J. M., Lowrey, P. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80245-7 · Cited by 1,382 · see citing works

Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels

Hardin, P. E., Hall, J. C., & Rosbash, M. (1990) · Nature · doi:10.1038/343536a0 · Cited by 1,156 · see citing works

Persistence of circadian rhythmicity in a mammalian hypothalamic “island” containing the suprachiasmatic nucleus

Inouye, S. T., & Kawamura, H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.11.5962 · Cited by 985 · see citing works

A Mutation of the Circadian System in Golden Hamsters

Ralph, M. R., & Menaker, M. (1988) · Science · doi:10.1126/science.3413487 · Cited by 700 · see citing works

Functional Identification of the Mouse Circadian Clock Gene by Transgenic BAC Rescue

Antoch, M. P., Song, E.-J., Chang, A., Vitaterna, M. H., Zhao, Y., Wilsbacher, L. D., Sangoram, A. M., King, D. P., Pinto, L. H., & Takahashi, J. S. (1997) · Cell · doi:10.1016/s0092-8674(00)80246-9 · Cited by 665 · see citing works

Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila

Zerr, D., Hall, J. C., Rosbash, M., & Siwicki, K. K. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-08-02749.1990 · Cited by 401 · see citing works

Block in Nuclear Localization of period Protein by a Second Clock Mutation, timeless

Vosshall, L. B., Price, J. L., Sehgal, A., Sáez, L., & Young, M. W. (1994) · Science · doi:10.1126/science.8128247 · Cited by 371 · see citing works

Suprachiasmatic Nucleus: Use of ¹⁴ C-Labeled Deoxyglucose Uptake as a Functional Marker

Schwartz, W. J., & Gainer, H. (1977) · Science · doi:10.1126/science.887940 · Cited by 358 · see citing works

Regulation of Nuclear Entry of the Drosophila Clock Proteins Period and Timeless

Sáez, L., & Young, M. W. (1996) · Neuron · doi:10.1016/s0896-6273(00)80222-6 · Cited by 330 · see citing works

Changes in abundance or structure of the per gene product can alter periodicity of the Drosophila clock

Baylies, M. K., Bargiello, T. A., Jackson, F. R., & Young, M. W. (1987) · Nature · doi:10.1038/326390a0 · Cited by 231 · see citing works

A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene

Citri, Y., Colot, H. V., Jacquier, A. C., Yu, Q., Hall, J. C., Baltimore, D., & Rosbash, M. (1987) · Nature · doi:10.1038/326042a0 · Cited by 231 · see citing works

The hypothalamic suprachiasmatic nuclei: Circadian patterns of vasopressin secretion and neuronal activity in vitro

Gillette, M. U., & Reppert, S. M. (1987) · Brain Research Bulletin · doi:10.1016/0361-9230(87)90176-6 · Cited by 195 · see citing works

Molecular Transfer of a Species-specific Behavior from Drosophila simulans to Drosophila melanogaster

Wheeler, D. A., Kyriacou, C. P., Greenacre, M. L., Yu, Q., Rutila, J. E., Rosbash, M., & Hall, J. C. (1991) · Science · doi:10.1126/science.1900131 · Cited by 184 · see citing works

Spatial and temporal expression of the period gene in Drosophila melanogaster.Preprint

Liu, X., Lorenz, L. J., Yu, Q. N., Hall, J. C., & Rosbash, M. (1988) · Genes & Development · doi:10.1101/gad.2.2.228 · Cited by 156 · see citing works

PER Protein Interactions and Temperature Compensation of a Circadian Clock in Drosophila

Huang, Z. J., Curtin, K. D., & Rosbash, M. (1995) · Science · doi:10.1126/science.7855598 · Cited by 152 · see citing works

Interspecific comparison of the period gene of Drosophila reveals large blocks of non‐conserved coding DNA.

Colot, H. V., Hall, J. C., & Rosbash, M. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03279.x · Cited by 143 · see citing works

Cloning of a structural and functional homolog of the circadian clock gene period from the giant silkmoth antheraea pernyi

Reppert, S. M., Tsai, T., Roca, A. L., & Saumant, I. (1994) · Neuron · doi:10.1016/0896-6273(94)90054-x · Cited by 132 · see citing works

In situ localization of the per clock protein during development of Drosophila melanogaster.

Sáez, L., & Young, M. W. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.12.5378 · Cited by 101 · see citing works

Development of Vasoactive Intestinal Peptide mRNA Rhythm in the Rat Suprachiasmatic Nucleus

Ban, Y., Shigeyoshi, Y., & Okamura, H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03920.1997 · Cited by 90 · see citing works

Pulsed‐field polyacrylamide gel electrophoresis: Basic phenomena and applications

Ito, T., Hohjoh, H., & Sakaki, Y. (1993) · Electrophoresis · doi:10.1002/elps.1150140149 · Cited by 7 · see citing works

Molecular Bases for Circadian Clocks

Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900 · see citing works

The mammalian circadian timing system: organization and coordination of central and peripheral clocks

Dibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421 · see citing works

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001 · see citing works

Role of the CLOCK Protein in the Mammalian Circadian Mechanism

Gekakis, N., Staknis, D., Nguyen, H. B., Davis, F. C., Wilsbacher, L. D., King, D. P., Takahashi, J. S., & Weitz, C. J. (1998) · Science · doi:10.1126/science.280.5369.1564 · Cited by 1,997 · see citing works

Resetting central and peripheral circadian oscillators in transgenic rats

Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907 · see citing works

Stability, precision, and near-24-hour period of the human circadian pacemaker

Czeisler, C. A., Duffy, J. F., Shanahan, T. L., Brown, E. N., Mitchell, J. F., Rimmer, D. W., Ronda, J. M., Silva, E. J., Allan, J. S., Emens, J. S., et al. (1999) · Science · doi:10.1126/science.284.5423.2177 · Cited by 1,705 · see citing works

PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light

Taylor, B. L., & Zhulin, I. B. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.479-506.1999 · Cited by 1,632 · see citing works

mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop

Kume, K., Zylka, M. J., Sriram, S., Shearman, L. P., Weaver, D. R., Jin, X., Maywood, E. S., Hastings, M. H., & Reppert, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)81014-4 · Cited by 1,617 · see citing works

Molecular analysis of mammalian circadian rhythms

Reppert, S. M., & Weaver, D. R. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.647 · Cited by 1,444 · see citing works

Interacting molecular loops in the mammalian circadian clock

Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der, G. T. J., Horst, et al. (2000) · Science · doi:10.1126/science.288.5468.1013 · Cited by 1,367 · see citing works

Time zones: a comparative genetics of circadian clocks

Young, M. W., & Kay, S. A. (2001) · Nature Reviews Genetics · doi:10.1038/35088576 · Cited by 1,143 · see citing works

Constitutive Expression of the CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) Gene Disrupts Circadian Rhythms and Suppresses Its Own Expression

Wang, Z., & Tobin, E. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81464-6 · Cited by 1,034 · see citing works

The PAS Superfamily: Sensors of Environmental and Developmental Signals

Gu, Y.-Z., Hogenesch, J. B., & Bradfield, C. A. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.519 · Cited by 1,023 · see citing works

CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity

Emery, P., So, W. V., Kaneko, M., Hall, J. C., & Rosbash, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81637-2 · Cited by 912 · see citing works

The Meter of Metabolism

Green, C. B., Takahashi, J. S., & Bass, J. (2008) · Cell · doi:10.1016/j.cell.2008.08.022 · Cited by 902 · see citing works

Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.

Zheng, B., Albrecht, U., Kaasik, K., Sage, M., Lu, W., Vaishnav, S., Li, Q., Sun, Z. S., Eichele, G., Bradley, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00380-4 · Cited by 900 · see citing works

Light-Induced Resetting of a Mammalian Circadian Clock Is Associated with Rapid Induction of the Transcript

Shigeyoshi, Y., Taguchi, K., Yamamoto, S., Takekida, S., Yan, L., Tei, H., Moriya, T., Shibata, S., Loros, J. J., Dunlap, J. C., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80494-8 · Cited by 891 · see citing works

A Molecular Mechanism Regulating Rhythmic Output from the Suprachiasmatic Circadian Clock

Jin, X., Shearman, L. P., Weaver, D. R., Zylka, M. J., Vries, G. J. D., & Reppert, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80959-9 · Cited by 891 · see citing works

A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light

Albrecht, U., Sun, Z. S., Eichele, G., & Lee, C. C. (1997) · Cell · doi:10.1016/s0092-8674(00)80495-x · Cited by 879 · see citing works

Three period Homologs in Mammals: Differential Light Responses in the Suprachiasmatic Circadian Clock and Oscillating Transcripts Outside of Brain

Zylka, M. J., Shearman, L. P., Weaver, D. R., & Reppert, S. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80492-4 · Cited by 865 · see citing works

Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau

Lowrey, P. L., Shimomura, K., Antoch, M. P., Yamazaki, S., Zemenides, P. D., Ralph, M. R., Menaker, M., & Takahashi, J. S. (2000) · Science · doi:10.1126/science.288.5465.483 · Cited by 860 · see citing works

double-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation

Price, J. L., Blau, J., Rothenfluh, A., Abodeely, M., Kloss, B., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81224-6 · Cited by 839 · see citing works

System-level identification of transcriptional circuits underlying mammalian circadian clocks

Ueda, H. R., Hayashi, S., Chen, W., Sano, M., Machida, M., Shigeyoshi, Y., Iino, M., & Hashimoto, S. (2005) · Nature Genetics · doi:10.1038/ng1504 · Cited by 786 · see citing works

Two period Homologs: Circadian Expression and Photic Regulation in the Suprachiasmatic Nuclei

Shearman, L. P., Zylka, M. J., Weaver, D. R., Kolakowski, L. F., & Reppert, S. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80417-1 · Cited by 781 · see citing works

The basic-helix–loop–helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors

Hogenesch, J. B., Gu, Y.-Z., Jain, S. R., & Bradfield, C. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5474 · Cited by 781 · see citing works

Expression of a Gene Cluster kaiABC as a Circadian Feedback Process in Cyanobacteria

Ishiura, M., Kutsuna, S., Aoki, S., Iwasaki, H., Andersson, C. R., Tanabe, A., Golden, S. S., Johnson, C. H., & Kondo, T. (1998) · Science · doi:10.1126/science.281.5382.1519 · Cited by 760 · see citing works

A Mutant Drosophila Homolog of Mammalian Clock Disrupts Circadian Rhythms and Transcription of period and timeless

Allada, R., White, N. E., So, W. V., Hall, J. C., & Rosbash, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81440-3 · Cited by 744 · see citing works

The mPer2 gene encodes a functional component of the mammalian circadian clock

Zheng, B., Larkin, D. W., Albrecht, U., Sun, Z. S., Sage, M., Eichele, G., Lee, C. C., & Bradley, A. (1999) · Nature · doi:10.1038/22118 · Cited by 718 · see citing works

Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus

Cheng, M. Y., Bullock, C. M., Li, C., Lee, A. G., Bermak, J. C., Belluzzi, J., Weaver, D. R., Leslie, F. M., & Zhou, Q.-Y. (2002) · Nature · doi:10.1038/417405a · Cited by 715 · see citing works

Differential regulation of mammalian <i>Period</i> genes and circadian rhythmicity by cryptochromes 1 and 2

Vitaterna, M. H., Selby, C. P., Todo, T., Niwa, H., Thompson, C., Fruechte, E. M., Hitomi, K., Thresher, R. J., Ishikawa, T., Miyazaki, J., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12114 · Cited by 690 · see citing works

The Drosophila Clock Gene double-time Encodes a Protein Closely Related to Human Casein Kinase Iε

Kloss, B., Price, J. L., Sáez, L., Blau, J., Rothenfluh, A., Wesley, C. S., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81225-8 · Cited by 682 · see citing works

Circadian rhythms in isolated brain regions

Abe, M., Herzog, E. D., Yamazaki, S., Straume, M., Tei, H., Sakaki, Y., Menaker, M., & Block, G. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00350.2002 · Cited by 681 · see citing works

The circadian clock: pacemaker and tumour suppressor

Fu, L., & Lee, C. C. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1072 · Cited by 678 · see citing works

Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of theCBP/p300 coactivator by the hypoxia‐induciblefactor‐1α

Kallio, P., Okamoto, K., O'Brien, S., Carrero, P., Makino, Y., Tanaka, H., & Poellinger, L. (1998) · EMBO Journal · doi:10.1093/emboj/17.22.6573 · Cited by 707 · see citing works

Light-Independent Role of CRY1 and CRY2 in the Mammalian Circadian Clock

Griffin, E. A., Staknis, D., & Weitz, C. J. (1999) · Science · doi:10.1126/science.286.5440.768 · Cited by 646 · see citing works

Circadian rhythm disturbances in depression

Germain, A., & Kupfer, D. J. (2008) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.964 · Cited by 644 · see citing works

CYCLE Is a Second bHLH-PAS Clock Protein Essential for Circadian Rhythmicity and Transcription of Drosophila period and timeless

Rutila, J. E., Suri, V., Le, M., So, W. V., Rosbash, M., & Hall, J. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81441-5 · Cited by 643 · see citing works

Independent Photoreceptive Circadian Clocks Throughout Drosophila

Plautz, J. D., Kaneko, M. A. N., Hall, J. C., & Kay, S. A. (1997) · Science · doi:10.1126/science.278.5343.1632 · Cited by 640 · see citing works

A bioluminescence resonance energy transfer (BRET) system: Application to interacting circadian clock proteins

Xu, Y. Q., Piston, D. W., & Johnson, C. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.1.151 · Cited by 613 · see citing works

Light activates the adrenal gland: Timing of gene expression and glucocorticoid release

Ishida, A., Mutoh, T., Ueyama, T., Bando, H., Masubuchi, S., Nakahara, D., Tsujimoto, G., & Okamura, H. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.009 · Cited by 589 · see citing works

A CLOCK Polymorphism Associated with Human Diurnal Preference

Katzenberg, D. R., Young, T. B., Finn, L. A., Lin, L., King, D. P., Takahashi, J. S., & Mignot, E. J.-M. (1998) · SLEEP · doi:10.1093/sleep/21.6.569 · Cited by 587 · see citing works

Hypothalamic integration of central and peripheral clocks

Buijs, R. M., & Kalsbeek, A. (2001) · Nature reviews. Neuroscience · doi:10.1038/35081582 · Cited by 580 · see citing works

Molecular Genetics of Circadian Rhythms in Mammals

King, D. P., & Takahashi, J. S. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.713 · Cited by 551 · see citing works

Genomics of circadian rhythms in health and disease

Rijo‐Ferreira, F., & Takahashi, J. S. (2019) · Genome Medicine · doi:10.1186/s13073-019-0704-0 · Cited by 537 · see citing works

Cellular Construction of a Circadian Clock: Period Determination in the Suprachiasmatic Nuclei

Liu, C., Weaver, D. R., Strogatz, S. H., & Reppert, S. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80473-0 · Cited by 508 · see citing works

The Suprachiasmatic Nucleus: A 25-Year Retrospective

Weaver, D. R. (1998) · Journal of Biological Rhythms · doi:10.1177/074873098128999952 · Cited by 508 · see citing works

Cocaine sensitization and reward are under the influence of circadian genes and rhythm

Abarca, C., Albrecht, U., & Spanagel, R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142039099 · Cited by 472 · see citing works

Glucocorticoid hormones inhibit food‐induced phase‐shifting of peripheral circadian oscillators

Minh, N. L., Damiola, F., Tronche, F., Schütz, G., & Schibler, U. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.7128 · Cited by 467 · see citing works

Role of the circadian system in cardiovascular disease

Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443 · see citing works

Effects of Chronic Jet Lag on Tumor Progression in Mice

Filipski, E., Delaunay, F., King, V. M., Wu, M., Claustrat, B., Gréchez‐Cassiau, A., Guettier, C., Hastings, M. H., & Lévi, F. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0674 · Cited by 416 · see citing works

Vitamin B 2 -based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals

Miyamoto, Y., & Sancar, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6097 · Cited by 406 · see citing works

Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanismPreprint

Mitsui, S., Yamaguchi, S., Matsuo, T., Ishida, Y., & Okamura, H. (2001) · Genes & Development · doi:10.1101/gad.873501 · Cited by 403 · see citing works

Role of Mouse Cryptochrome Blue-Light Photoreceptor in Circadian Photoresponses

Thresher, R., Vitaterna, M. H., Miyamoto, Y., Kazantsev, A. G., Hsu, D. S., Petit, C. R., Selby, C. P., Dawut, L., Smithies, O., Takahashi, J. S., et al. (1998) · Science · doi:10.1126/science.282.5393.1490 · Cited by 401 · see citing works

Circadian Expression of Clock Genes in Human Oral Mucosa and Skin

Bjarnason, G. A., Jordan, R. C., Wood, P. A., Li, Q., Lincoln, D. W., Sothern, R. B., Hrushesky, W. J. M., & Ben‐David, Y. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64135-1 · Cited by 379 · see citing works

<i>mPer1</i> and <i>mPer2</i> Are Essential for Normal Resetting of the Circadian Clock

Albrecht, U., Zheng, B., Larkin, D., Sun, Z. S., & Lee, C. C. (2001) · Journal of Biological Rhythms · doi:10.1177/074873001129001791 · Cited by 375 · see citing works

Photic Induction of mPer1 and mPer2 in Cry -Deficient Mice Lacking a Biological Clock

Okamura, H., Miyake, S., Sumi, Y., Yamaguchi, S., Yasui, A., Muijtjens, M., Hoeijmakers, J. H. J., & van der Horst, G. T. J. (1999) · Science · doi:10.1126/science.286.5449.2531 · Cited by 375 · see citing works

Light and circadian rhythmicity regulate MAP kinase activation in the suprachiasmatic nuclei

Obrietan, K. H., Impey, S., & Storm, D. R. (1998) · Nature Neuroscience · doi:10.1038/3695 · Cited by 369 · see citing works

The aryl hydrocarbon receptor: A comparative perspective

Hahn, M. E. (1998) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/s0742-8413(98)10028-2 · Cited by 366 · see citing works

The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors

Schmutz, I., Ripperger, J. A., Baeriswyl-Aebischer, S., & Albrecht, U. (2010) · Genes &amp; Development · doi:10.1101/gad.564110 · Cited by 361 · see citing works

Zebrafish Clock rhythmic expression reveals independent peripheral circadian oscillators

Whitmore, D., Foulkes, N. S., Strähle, U., & Sassone‐Corsi, P. (1998) · Nature Neuroscience · doi:10.1038/3703 · Cited by 357 · see citing works

Mammalian Circadian Autoregulatory Loop

Sangoram, A. M., Sáez, L., Antoch, M. P., Gekakis, N., Staknis, D., Whiteley, A. R., Fruechte, E. M., Vitaterna, M. H., Shimomura, K., King, D. P., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80627-3 · Cited by 355 · see citing works

Sex differences in circadian timing systems: implications for disease

Bailey, M., & Silver, R. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.11.003 · Cited by 348 · see citing works

Control of cell lineage-specific development and transcription by bHLH-PAS proteinsPreprint

Crews, S. T. (1998) · Genes & Development · doi:10.1101/gad.12.5.607 · Cited by 346 · see citing works

Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms

Field, M. D., Maywood, E. S., O'Brien, J. A., Weaver, D. R., Reppert, S. M., & Hastings, M. H. (2000) · Neuron · doi:10.1016/s0896-6273(00)80906-x · Cited by 343 · see citing works

Mice Genetically Deficient in Vasopressin V1a and V1b Receptors Are Resistant to Jet Lag

Yamaguchi, Y., Suzuki, T., Mizoro, Y., Kori, H., Okada, K., Chen, Y., Fustin, J., Yamazaki, F., Mizuguchi, N., Zhang, J., et al. (2013) · Science · doi:10.1126/science.1238599 · Cited by 334 · see citing works

Natural Variation in a Drosophila Clock Gene and Temperature Compensation

Sawyer, L., Hennessy, J. M., Peixoto, A. A., Rosato, E., Parkinson, H., Costa, R., & Kyriacou, C. P. (1997) · Science · doi:10.1126/science.278.5346.2117 · Cited by 320 · see citing works

Stopping Time: The Genetics of Fly and Mouse Circadian Clocks

Allada, R., Emery, P., Takahashi, J. S., & Rosbash, M. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1091 · Cited by 315 · see citing works

Restricted‐feeding‐induced anticipatory activity rhythm is associated with a phase‐shift of the expression of <i>mPer1</i> and <i>mPer2</i> mRNA in the cerebral cortex and hippocampus but not in the suprachiasmatic nucleus of mice

Wakamatsu, H., Yoshinobu, Y., Aida, R., Moriya, T., Akiyama, M., & Shibata, S. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01483.x · Cited by 308 · see citing works

Nuclear Entry of the Circadian Regulator mPER1 Is Controlled by Mammalian Casein Kinase I ɛ

Vielhaber, E. L., Eide, E. J., Rivers, A. M., Gao, Z.-H., & Virshup, D. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4888-4899.2000 · Cited by 308 · see citing works

Acute Physical Stress Elevates Mouse Period1 mRNA Expression in Mouse Peripheral Tissues via a Glucocorticoid-responsive Element

Yamamoto, T., Nakahata, Y., Tanaka, M., Yoshida, M., Soma, H., Shinohara, K., Yasuda, A., Mamine, T., & Takumi, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509600200 · Cited by 302 · see citing works

Multitissue Circadian Expression of Rat periodHomolog (rPer2) mRNA Is Governed by the Mammalian Circadian Clock, the Suprachiasmatic Nucleus in the Brain

Sakamoto, K., Nagase, T., Fukui, H., Horikawa, K., Okada, T., Tanaka, H., Sato, K. Z., Miyake, Y., Ohara, O., Kako, K., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27039 · Cited by 300 · see citing works

The suprachiasmatic nucleus and the circadian time-keeping system revisited

van Esseveldt, L. E., Lehman, M. N., & Boer, G. J. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00025-4 · Cited by 296 · see citing works

SCFβ-TRCP Controls Clock-dependent Transcription via Casein Kinase 1-dependent Degradation of the Mammalian Period-1 (Per1) Proteinm

Shirogane, T., Jin, J., Cambronne, X. A., & Harper, J. W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502862200 · Cited by 293 · see citing works

GENETICS OF THE MAMMALIAN CIRCADIAN SYSTEM: Photic Entrainment, Circadian Pacemaker Mechanisms, and Posttranslational Regulation

Lowrey, P. L., & Takahashi, J. S. (2000) · Annual Review of Genetics · doi:10.1146/annurev.genet.34.1.533 · Cited by 293 · see citing works

Control of Intracellular Dynamics of Mammalian Period Proteins by Casein Kinase I ε (CKIε) and CKIδ in Cultured Cells

Akashi, M., Tsuchiya, Y., Yoshino, T., & Nishida, E. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1693-1703.2002 · Cited by 292 · see citing works

Circadian rhythms in a nutshell

Edery, I. (2000) · Physiological Genomics · doi:10.1152/physiolgenomics.2000.3.2.59 · Cited by 284 · see citing works

An Abrupt Shift in the Day/Night Cycle Causes Desynchrony in the Mammalian Circadian Center

Nagano, M., Adachi, A. A., Nakahama, K., Nakamura, T., Tamada, M., Meyer-Bernstein, E. L., Sehgal, A., & Shigeyoshi, Y. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-14-06141.2003 · Cited by 273 · see citing works

Involvement of the MAP kinase cascade in resetting of the mammalian circadian clockPreprint

Akashi, M., & Nishida, E. (2000) · Genes & Development · doi:10.1101/gad.14.6.645 · Cited by 269 · see citing works

Limit Cycle Models for Circadian Rhythms Based on Transcriptional Regulation in Drosophila and Neurospora

Leloup, J., Gonze, D., & Goldbeter, A. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000948 · Cited by 266 · see citing works

Inhibition of Light- or Glutamate-InducedmPer1Expression Represses the Phase Shifts into the Mouse Circadian Locomotor and Suprachiasmatic Firing Rhythms

Akiyama, M., Kouzu, Y., Takahashi, S., Wakamatsu, H., Moriya, T., Maetani, M., Watanabe, S., Tei, H., Sakaki, Y., & Shibata, S. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-03-01115.1999 · Cited by 264 · see citing works

Cryptochrome: The Second Photoactive Pigment in the Eye and Its Role in Circadian Photoreception

Sancar, A. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.31 · Cited by 263 · see citing works

Forskolin induces circadian gene expression of rPer1, rPer2 and dbp in mammalian rat‐1 fibroblasts

Yagita, K., & Okamura, H. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01724-x · Cited by 258 · see citing works

Antiphase Circadian Expression betweenBMAL1andperiodHomologue mRNA in the Suprachiasmatic Nucleus and Peripheral Tissues of Rats

Oishi, K., Sakamoto, K., Okada, T., Nagase, T., & Ishida, N. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9779 · Cited by 257 · see citing works

Dynamic mechanistic explanation: computational modeling of circadian rhythms as an exemplar for cognitive science

Bechtel, W., & Abrahamsen, A. A. (2010) · Studies in History and Philosophy of Science Part A · doi:10.1016/j.shpsa.2010.07.003 · Cited by 257 · see citing works

Intrinsic near-24-h pacemaker period determines limits of circadian entrainment to a weak synchronizer in humans

Wright, K. P., Hughes, R. J., Kronauer, R. E., Dijk, D., & Czeisler, C. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.201530198 · Cited by 254 · see citing works

Altered behavioral rhythms and clock gene expression in mice with a targeted mutation in the Period1 gene

Cermakian, N., Monaco, L., Pando, M. P., Dierich, A., & Sassone‐Corsi, P. (2001) · The EMBO Journal · doi:10.1093/emboj/20.15.3967 · Cited by 252 · see citing works

Role of DBP in the Circadian Oscillatory Mechanism

Yamaguchi, S., Mitsui, S., Yan, L., Yagita, K., Miyake, S., & Okamura, H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4773-4781.2000 · Cited by 252 · see citing works

Clock Genes in the Heart

Young, M. E., Razeghi, P., & Taegtmeyer, H. (2001) · Circulation Research · doi:10.1161/hh1101.091190 · Cited by 251 · see citing works

Cancer chronotherapy: Principles, applications, and perspectives

Mormont, M., & Lévi, F. (2002) · Cancer · doi:10.1002/cncr.11040 · Cited by 251 · see citing works

Rapid down-regulation of mammalian Period genes during behavioral resetting of the circadian clock

Maywood, E. S., Mrosovsky, N., Field, M. D., & Hastings, M. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15211 · Cited by 248 · see citing works

Post-transcriptional control of circadian rhythms

Kojima, S., Shingle, D. L., & Green, C. B. (2011) · Journal of Cell Science · doi:10.1242/jcs.065771 · Cited by 247 · see citing works

The Implications of Multiple Circadian Clock Origins

Rosbash, M. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000062 · Cited by 239 · see citing works

BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock systemPreprint

Kondratov, R. V., Chernov, M. V., Kondratova, A. A., Gorbacheva, V., Gudkov, A. V., & Antoch, M. P. (2003) · Genes & Development · doi:10.1101/gad.1099503 · Cited by 238 · see citing works

Per1 and Per2 gene expression in the rat suprachiasmatic nucleus: circadian profile and the compartment-specific response to light

Yan, L., Takekida, S., Shigeyoshi, Y., & Okamura, H. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00223-7 · Cited by 237 · see citing works

A light‐independent oscillatory gene mPer3 in mouse SCN and OVLT

Takumi, T., Taguchi, K., Miyake, S., Sakakida, Y., Takashima, N., Matsubara, C., Maebayashi, Y., Okumura, K., Takekida, S., Yamamoto, S., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.16.4753 · Cited by 236 · see citing works

Advances in understanding the peripheral circadian clocks

Richards, J., & Gumz, M. L. (2012) · The FASEB Journal · doi:10.1096/fj.12-203554 · Cited by 233 · see citing works

A sense of time: how molecular clocks organize metabolism

Kohsaka, A., & Bass, J. T. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.11.005 · Cited by 233 · see citing works

The mammalian circadian system: a hierarchical multi-oscillator structure for generating circadian rhythm

Honma, S. (2018) · The Journal of Physiological Sciences · doi:10.1007/s12576-018-0597-5 · Cited by 233 · see citing works

The circadian clock ofNeurospora crassa

Baker, C. L., Loros, J., & Dunlap, J. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00288.x · Cited by 231 · see citing works

The Drosophila CLOCK Protein Undergoes Daily Rhythms in Abundance, Phosphorylation, and Interactions with the PER–TIM Complex

Lee, C., Bae, K., & Edery, I. (1998) · Neuron · doi:10.1016/s0896-6273(00)80601-7 · Cited by 231 · see citing works

Two period Homologs: Circadian Expression and Photic Regulation in the Suprachiasmatic Nuclei

Shearman, L. P., Zylka, M. J., Weaver, D. R., Kolakowski, L. F., & Reppert, S. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80417-1 · Cited by 781 · see citing works

The mPer2 gene encodes a functional component of the mammalian circadian clock

Zheng, B., Larkin, D. W., Albrecht, U., Sun, Z. S., Sage, M., Eichele, G., Lee, C. C., & Bradley, A. (1999) · Nature · doi:10.1038/22118 · Cited by 718 · see citing works

Circadian Regulation of a Drosophila Homolog of the Mammalian Clock Gene: PER and TIM Function as Positive Regulators

Bae, K., Lee, C., Sidote, D. J., Chuang, K.-Y., & Edery, I. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.10.6142 · Cited by 221 · see citing works

Functional analysis of mammalian per homologues by overexpression systems

Miyazaki, K., & Ishida, N. (1998) · Neuroscience Research · doi:10.1016/s0168-0102(98)82297-9

PERpetuating the PASt

Sassone‐Corsi, P. (1997) · Nature · doi:10.1038/38904 · Cited by 14 · see citing works