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Cited by 240Bacterial Infections and VaccinesBacterial Genetics and BiotechnologyIron Metabolism and Disorders

The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.

Iron acquisition systems in the pathogenic Neisseria

Schryvers, Anthony B., Stojiljkovic, Igor·1999·Molecular Microbiology
DOI 10.1046/j.1365-2958.1999.01411.x
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Abstract

Pathogenic neisseriae have a repertoire of high‐affinity iron uptake systems to facilitate acquisition of this essential element in the human host. They possess surface receptor proteins that directly bind the extracellular host iron‐binding proteins transferrin and lactoferrin. Alternatively, they have siderophore receptors capable of scavenging iron when exogenous siderophores are present. Released intracellular haem iron present in the form of haemoglobin, haemoglobin–haptoglobin or free haem can be used directly as a source of iron for growth through direct binding by specific surface receptors. Although these receptors may vary in complexity and composition, the key protein involved in the transport of iron (as iron, haem or iron‐siderophore) across the outer membrane is a TonB‐dependent receptor with an overall structure presumably similar to that determined recently for Escherichia coli FhuA or FepA. The receptors are potentially ideal vaccine targets in view of their critical role in survival in the host. Preliminary pilot studies indicate that transferrin receptor‐based vaccines may be protective in humans.

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Crossref · 10.1046/j.1365-2958.1999.01411.x

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35 of 35 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 2

  1. Lissolo L. Dumas P. Maitre G. Quentin‐Millet M.J.(1994) Preliminary biochemical characterization of transferrin binding proteins fromNeisseria meningitidis. InPathobiology and Immunobiology of Neisseriaceae. Conde‐Glez C.J. Morse S. Rice P. Sparling F. and Calderon E. (eds). Mexico: Publications Office INSP pp.399–405.
  2. Sassa S.&Kappas A.(1995) Disorders of heme production and catabolism. InBlood Principles and Practice of Hematology. Handlin R.I. Lux S.E. and Stossel T.P. (eds). Philadelphia: J.B. Lippincott pp.1473.

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Metadata

Authors
Schryvers, A. B., & Stojiljkovic, I.
Affiliations
University of Calgary (CA)
Corresponding author
Schryvers, Anthony B.
ORCID
Schryvers, Anthony B.
Venue
Molecular Microbiology
Publisher
Wiley
Published
1999-06
Volume
32
Issue
6
Pages
1117-1123
ISSN
  • 0950-382X (ISSN-L)
  • 1365-2958
DOI
10.1046/j.1365-2958.1999.01411.x
OpenAlex
W2035814555
Cited by
240
References
36
Citations by year
2025: 1 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 1 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 6 · 2014: 7 · 2013: 10 · 2012: 8
FWCI
2.44
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1004 d)
Locations
  • Molecular Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
iron acquisition, Neisseria, siderophores, transferrin receptor, lactoferrin, hemoglobin, TonB-dependent receptors, outer membrane transport, vaccine targets, bacterial virulence
MeSH terms
Humans, Iron, Neisseria

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