The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The putative iron transport system SitABCD encoded on SPI1 is required for full virulence of Salmonella typhimurium
Abstract
Salmonella typhimurium is an invasive pathogen that causes diseases ranging from mild gastroenteritis to enteric fever. During the infection process, S. typhimurium induces a number of virulence genes required to circumvent host defences and/or acquire nutrients in the host. We have used the in vivo expression technology (IVET) system to select for S. typhimurium genes that are induced after invasion of a murine cultured cell line. We have characterized a putative iron transporter in Salmonella pathogenicity island 1, termed sitABCD. The sitABCD operon is induced under iron‐deficient conditions in vitro and is repressed by Fur. This locus is induced in the animal specifically after invasion of the intestinal epithelium. We show that a sit null mutant is significantly attenuated in BALB/c mice, suggesting that SitABCD plays an important role in iron acquisition in the animal.
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Cites
Characterization of the ferrous iron uptake system of Escherichia coli
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Identification of a Salmonella typhimurium invasion locus by selection for hyperinvasive mutants
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Contribution of TonB- and Feo-mediated iron uptake to growth of Salmonella typhimurium in the mouse
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Cited by
Andrews, S. C., Robinson, A. K., & Rodríguez-Quiñones, F. (2003) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(03)00055-x · Cited by 2,702
Staphylococcus aureus Serves as an Iron Source for Pseudomonas aeruginosa during In Vivo Coculture
Mashburn, L. M., Jett, A. M., Akins, D. R., & Whiteley, M. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.2.554-566.2005 · Cited by 312
Brown, J. S., Gilliland, S. M., & Holden, D. W. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02414.x · Cited by 288
Nutritional iron turned inside out: intestinal stress from a gut microbial perspective
Kortman, G. A. M., Raffatellu, M., Swinkels, D. W., & Tjalsma, H. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12086 · Cited by 291
Forbes, J. R., & Gros, P. (2003) · Blood · doi:10.1182/blood-2003-02-0425 · Cited by 288
Metadata
- Authors
- Janakiraman, A., & Slauch, J. M.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2000-03
- Volume
- 35
- Issue
- 5
- Pages
- 1146-1155
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W1963715448
- Cited by
- 234
- References
- 6
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Janakiraman, A., & Slauch, J. M. (2000). The putative iron transport system SitABCD encoded on SPI1 is required for full virulence of Salmonella typhimurium. Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.2000.01783.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
