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Elucidating the molecular mechanisms of bacterial virulence using non‐mammalian hosts
Open accessAbstract
Several strains of the human opportunistic pathogen Pseudomonas aeruginosa infect plants, nematodes and insects. Our laboratory has developed a multihost pathogenesis system based on the P. aeruginosa clinical isolate PA14, in which non‐mammalian hosts are used to screen directly for virulence‐attenuated mutants. The majority of PA14 mutants isolated using non‐mammalian hosts also displayed reduced virulence in a burned mouse model. Surprisingly, only a few host‐specific virulence factors were identified, and many of the P. aeruginosa mutants were attenuated in virulence in all the hosts. These studies illustrate the extensive conservation in the virulence mechanisms used by P. aeruginosa to infect evolutionarily diverged hosts, and validate the multihost method of screening for virulence factors relevant to mammalian pathogenesis. Through the use of genetically tractable hosts, the multihost pathogenesis model also provides tools for elucidating host responses and dissecting the fundamental molecular interactions that underlie bacterial pathogenesis.
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Cited by
The role of pyocyanin in Pseudomonas aeruginosa infection
Lau, G. W., Hassett, D. J., Ran, H., & Kong, F. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.10.002 · Cited by 688
Pseudomonas aeruginosa PAO1 Kills Caenorhabditis elegans by Cyanide Poisoning
Gallagher, L. A., & Manoil, C. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.21.6207-6214.2001 · Cited by 435
Community surveillance enhances Pseudomonas aeruginosa virulence during polymicrobial infection
Korgaonkar, A., Trivedi, U., Rumbaugh, K. P., & Whiteley, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214550110 · Cited by 315
Pukatzki, S., Kessin, R. H., & Mekalanos, J. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052704399 · Cited by 289
Metadata
- Authors
- Mahajan‐Miklos, S., Rahme, L. G., & Ausubel, F. M.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2000-09
- Volume
- 37
- Issue
- 5
- Pages
- 981-988
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2151098931
- Cited by
- 181
- References
- 0
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mahajan‐Miklos, S., Rahme, L. G., & Ausubel, F. M. (2000). Elucidating the molecular mechanisms of bacterial virulence using non‐mammalian hosts. Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.2000.02056.x
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
