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Cited by 434

The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.

Large‐scale monitoring of pleiotropic regulation of gene expression by the prokaryotic nucleoid‐associated protein, H‐NS

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Hommais, Florence, Krin, Evelyne, Laurent‐Winter, Christine, Soutourina, Olga, Malpertuy, Alain, Le Caer, Jean‐Pierre, Danchin, Antoine, Bertin, Philippe·2001·Molecular Microbiology
DOI 10.1046/j.1365-2958.2001.02358.x
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Abstract

Despite many years of intense work investigating the function of nucleoid‐associated proteins in prokaryotes, their role in bacterial physiology remains largely unknown. The two‐dimensional protein patterns were compared and expression profiling was carried out on H‐NS‐deficient and wild‐type strains of Escherichia coli K‐12. The expression of approximately 5% of the genes and/or the accumulation of their protein was directly or indirectly altered in the hns mutant strain. About one‐fifth of these genes encode proteins that are involved in transcription or translation and one‐third are known to or were in silico predicted to encode cell envelope components or proteins that are usually involved in bacterial adaptation to changes in environmental conditions. The increased expression of several genes in the mutant resulted in a better ability of this strain to survive at low pH and high osmolarity than the wild‐type strain. In particular, the putative regulator, YhiX, plays a central role in the H‐NS control of genes required in the glutamate‐dependent acid stress response. These results suggest that there is a strong relationship between the H‐NS regulon and the maintenance of intracellular homeostasis.

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Metadata

Authors
Hommais, F., Krin, E., Laurent‐Winter, C., Soutourina, O., Malpertuy, A., Le Caer, J., Danchin, A., & Bertin, P.
Venue
Molecular Microbiology
Publisher
Wiley
Published
2001-04
Volume
40
Issue
1
Pages
20-36
ISSN
  • 0950-382X (ISSN-L)
  • 1365-2958
DOI
10.1046/j.1365-2958.2001.02358.x
OpenAlex
W1574886161
Cited by
434
References
52
FWCI
16.05
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Large‐scale monitoring of pleiotropic regulation of gene expression by the prokaryotic nucleoid‐associated protein, H‐NS. https://app.cochat.ai/papers/10.1046/j.1365-2958.2001.02358.x
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Hommais, F., Krin, E., Laurent‐Winter, C., Soutourina, O., Malpertuy, A., Le Caer, J., Danchin, A., & Bertin, P. (2001). Large‐scale monitoring of pleiotropic regulation of gene expression by the prokaryotic nucleoid‐associated protein, H‐NS. Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.2001.02358.x

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