The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Widespread functional specialization of Plasmodium falciparum erythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genome
Abstract
Summary: Plasmodium falciparum ‐infected erythrocytes sequester from blood circulation by binding host endothelium. A large family of variant proteins mediates cytoadherence and their binding specificity determines parasite sequestration patterns and potential for disease. The aim of the present study was to understand how binding properties are encoded into family members and to develop sequence algorithms for predicting binding. To accomplish these goals computational approaches and a binding assay were used to characterize adhesion across Plasmodium falciparum erythrocyte membrane 1 (PfEMP1) proteins in the 3D7 parasite genome. We report that most family members encode the capacity to bind CD36 in the protein's semi‐conserved head structure and describe the sequence characteristics of a group of PfEMP1 proteins that do not. Structural and functional grouping of PfEMP1 proteins based upon head structure and additional domain architectural properties provide new insights into the protein family. These can be used to investigate the role of proteins in malaria pathogenesis and potentially tailor vaccines to recognize particular binding variants.
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Adherence of Plasmodium falciparum to Chondroitin Sulfate A in the Human Placenta
Fried, M., & Duffy, P. E. (1996) · Science · doi:10.1126/science.272.5267.1502 · Cited by 1,108
Ricke, C. H., Staalsoe, T., Koram, K., Akanmori, B. D., Riley, E. M., Theander, T. G., & Hviid, L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3309 · Cited by 303
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Staalsoe, T., Megnekou, R., Fievét, N., Ricke, C. H., Zornig, H. D., Leke, R., Taylor, D. W., Deloron, P., & Hviid, L. (2001) · The Journal of Infectious Diseases · doi:10.1086/322809 · Cited by 161
Two DBLγ subtypes are commonly expressed by placental isolates of Plasmodium falciparum
Fried, M., & Duffy, P. E. (2002) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(02)00103-2 · Cited by 44
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(2015) · Advances in Parasitology · doi:10.1016/bs.apar.2015.02.004 · Cited by 162
Trimnell, A. R., Kraemer, S. M., Mukherjee, S., Phippard, D. J., Janes, J. H., Flamoe, E., Su, X.-Z., Awadalla, P., & Smith, J. D. (2006) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2006.03.012 · Cited by 165
Self-citationGamain, B., Trimnell, A. R., Scheidig, C., Scherf, A., Miller, L. H., & Smith, J. D. (2005) · The Journal of Infectious Diseases · doi:10.1086/428137 · Cited by 145
Self-citationFrancis, S. E., Malkov, V. A., Oleinikov, A. V., Rossnagle, E., Wendler, J. P., Mutabingwa, T. K., Fried, M., & Duffy, P. E. (2007) · Infection and Immunity · doi:10.1128/iai.00635-07 · Cited by 65
Gamain, B., Smith, J. D., Avril, M., Baruch, D. I., Scherf, A., Gysin, J., & Miller, L. H. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04145.x · Cited by 40
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Metadata
- Authors
- Robinson, B. A., Welch, T. L., & Smith, J. D.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2003-02-19
- Volume
- 47
- Issue
- 5
- Pages
- 1265-1278
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2118663519
- Cited by
- 204
- References
- 6
- FWCI
- 12.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Robinson, B. A., Welch, T. L., & Smith, J. D. (2003). Widespread functional specialization of Plasmodium falciparum erythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genome. Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.2003.03378.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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