Rv3133c/ dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis

Park, Heui‐Dong; Guinn, Kristi M.; Harrell, Maria I.; Liao, Reiling; Voskuil, Martin I.; Tompa, Martin; Schoolnik, Gary K.; Sherman, David R.

doi:10.1046/j.1365-2958.2003.03474.x

Cited by 719Tuberculosis Research and EpidemiologyBacterial Genetics and BiotechnologyMycobacterium research and diagnosis

Rv3133c/ dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis

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Park, Heui‐Dong, Guinn, Kristi M., Harrell, Maria I., Liao, Reiling, Voskuil, Martin I., Tompa, Martin, Schoolnik, Gary K., Sherman, David R.·2003·Molecular Microbiology

DOI 10.1046/j.1365-2958.2003.03474.xPMC PMC1992516

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Abstract

Summary: Unlike many pathogens that are overtly harmful to their hosts, Mycobacterium tuberculosis can persist for years within humans in a clinically latent state. Latency is often linked to hypoxic conditions within the host. Among M. tuberculosis genes induced by hypoxia is a putative transcription factor, Rv3133c/DosR. We performed targeted disruption of this locus followed by transcriptome analysis of wild‐type and mutant bacilli. Nearly all the genes powerfully regulated by hypoxia require Rv3133c/DosR for their induction. Computer analysis identified a consensus motif, a variant of which is located upstream of nearly all M. tuberculosis genes rapidly induced by hypoxia. Further, Rv3133c/DosR binds to the two copies of this motif upstream of the hypoxic response gene alpha‐crystallin. Mutations within the binding sites abolish both Rv3133c/DosR binding as well as hypoxic induction of a downstream reporter gene. Also, mutation experiments with Rv3133c/DosR confirmed sequence‐based predictions that the C‐terminus is responsible for DNA binding and that the aspartate at position 54 is essential for function. Together, these results demonstrate that Rv3133c/DosR is a transcription factor of the two‐component response regulator class, and that it is the primary mediator of a hypoxic signal within M. tuberculosis .

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DosR acts as a transcriptional regulator responsible for inducing nearly all hypoxia-induced genes in M. tuberculosis.
“DosR has been shown to act as a transcriptional regulator, which is responsible for the induction of nearly all hypoxia-induced genes of M. tuberculosis (96).”
From Energetics of Respiration and Oxidative Phosphorylation in Mycobacteria (2014) · cites this paper as [96]
The Microarray analysis section reports that 26 of the 27 genes most powerfully induced by hypoxia require DosR, supporting its role as a transcriptional regulator. The Discussion limits this finding to genes powerfully induced by hypoxia and says numerous modestly induced genes do not appear to depend on DosR. The claim overextends that result to nearly all hypoxia-induced genes. (LLM, conf=0.89)
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Authors: Park, H., Guinn, K. M., Harrell, M. I., Liao, R., Voskuil, M. I., Tompa, M., Schoolnik, G. K., & Sherman, D. R.
Affiliations: University of Washington (US)
Stanford Medicine (US)
Corresponding author: Sherman, David R.
ORCID: Voskuil, Martin I.
Sherman, David R.
Venue: Molecular Microbiology
Publisher: Wiley
Published: 2003-04-09
Volume: 48
Issue: 3
Pages: 833-843
ISSN: 0950-382X (ISSN-L)
1365-2958
DOI: 10.1046/j.1365-2958.2003.03474.x
PMC: PMC1992516
OpenAlex: W2120842435
Cited by: 712
References: 61
Citations by year: 2026: 20 · 2025: 22 · 2024: 20 · 2023: 26 · 2022: 24 · 2021: 37 · 2020: 34 · 2019: 35 · 2018: 28 · 2017: 33 · 2016: 30 · 2015: 31 · 2014: 46 · 2013: 32 · 2012: 41
FWCI: 14.66
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Molecular Microbiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Science Foundation (9974498)
National Institutes of Health
National Human Genome Research Institute (HG02602-01, R01HG002602)
National Institute of Allergy and Infectious Diseases (R01AI044826, AI-44826, R21AI047744, AI47744, R01AI047744)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
Keywords: Mycobacterium tuberculosis, transcription factors, hypoxia response, hypoxia, transcriptional regulation, two-component response regulator, DNA-binding motifs, alpha-crystallin, latent tuberculosis infection, gene induction
MeSH terms: Hypoxia, Aspartic Acid, Bacterial Proteins, Humans, Mycobacterium tuberculosis, Oxygen, Protein Binding, Regulatory Sequences, Nucleic Acid, Transcription Factors, Tuberculosis, Gene Expression Regulation, Bacterial, Genes, Reporter, Gene Targeting, Oligonucleotide Array Sequence Analysis

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Rv3133c/ dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis

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