The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Involvement of bacterial migration in the development of complex multicellular structures in Pseudomonas aeruginosa biofilms
Abstract
Summary: Detailed knowledge of the developmental process from single cells scattered on a surface to complex multicellular biofilm structures is essential in order to create strategies to control biofilm development. In order to study bacterial migration patterns during Pseudomonas aeruginosa biofilm development, we have performed an investigation with time‐lapse confocal laser scanning microscopy of biofilms formed by various combinations of colour‐coded P. aeruginosa wild type and motility mutants. We show that mushroom‐shaped multicellular structures in P. aeruginosa biofilms can form in a sequential process involving a non‐motile bacterial subpopulation and a migrating bacterial subpopulation. The non‐motile bacteria form the mushroom stalks by growth in certain foci of the biofilm. The migrating bacteria form the mushroom caps by climbing the stalks and aggregating on the tops in a process which is driven by type‐IV pili. These results lead to a new model for biofilm formation by P. aeruginosa .
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Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., & Greenberg, E. P. (1998) · Science · doi:10.1126/science.280.5361.295 · Cited by 3,396
A component of innate immunity prevents bacterial biofilm development
Singh, P. K., Parsek, M. R., Greenberg, E. P., & Welsh, M. J. (2002) · Nature · doi:10.1038/417552a · Cited by 1,026
Cited by
Physiological heterogeneity in biofilms
Stewart, P. S., & Franklin, M. J. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1838 · Cited by 2,327
Raaijmakers, J. M., De Bruijn, I., Nybroe, O., & Ongena, M. (2010) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2010.00221.x · Cited by 1,131
The role of bacterial biofilms in chronic infections
Bjarnsholt, T. (2013) · APMIS · doi:10.1111/apm.12099 · Cited by 1,080
Sharma, S., Mohler, J., Mahajan, S. D., Schwartz, S. A., Bruggemann, L., & Aalinkeel, R. (2023) · Microorganisms · doi:10.3390/microorganisms11061614 · Cited by 993
Bjarnsholt, T., Alhede, M., Alhede, M., Eickhardt-Sørensen, S. R., Moser, C., Kühl, M., Jensen, P. Ø., & Høiby, N. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2013.06.002 · Cited by 764
Metadata
- Authors
- Klausen, M., Aaes‐Jørgensen, A., Molin, S., & Tolker‐Nielsen, T.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2003-08-20
- Volume
- 50
- Issue
- 1
- Pages
- 61-68
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2132927585
- Cited by
- 556
- References
- 3
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Klausen, M., Aaes‐Jørgensen, A., Molin, S., & Tolker‐Nielsen, T. (2003). Involvement of bacterial migration in the development of complex multicellular structures in Pseudomonas aeruginosa biofilms. Molecular Microbiology. https://doi.org/10.1046/j.1365-2958.2003.03677.x
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