The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cell wall stress responses in Bacillus subtilis: the regulatory network of the bacitracin stimulon
Abstract
Summary: In response to sublethal concentrations of antibiotics, bacteria often induce an adaptive response that can contribute to antibiotic resistance. We report the response of Bacillus subtilis to bacitracin, an inhibitor of cell wall biosynthesis found in its natural environment. Analysis of the global transcriptional profile of bacitracin‐treated cells reveals a response orchestrated by two alternative σ factors (σ B and σ M) and three two‐component systems (YvqEC, YvcPQ and BceRS). All three two‐component systems are located next to target genes that are strongly induced by bacitracin, and the corresponding histidine kinases share an unusual topology: they lack about 100 amino acids in their extracellular sensing domain, which is almost entirely buried in the cytoplasmic membrane. Sequence analysis indicates that this novel N‐terminal sensing domain is a characteristic feature of a subfamily of histidine kinases, found almost entirely in Gram‐positive bacteria and frequently linked to ABC transporters. A systematic mutational analysis of bacitracin‐induced genes led to the identification of a new bacitracin‐resistance determinant, bceAB, encoding a putative ABC transporter. The bcrC bacitracin resistance gene, which is under the dual control of σ X and σ M, was also induced by bacitracin. By comparing the bacitracin and the vancomycin stimulons, we can differentiate between loci induced specifically by bacitracin and those that are induced by multiple cell wall‐active antibiotics.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon
Baichoo, N., Wang, T., Ye, R., & Helmann, J. D. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03113.x · Cited by 250
Self-citation
Cited by
Stress Physiology of Lactic Acid Bacteria.
Papadimitriou, K., Alegría, Á., Bron, P. A., de Angelis, M., Gobbetti, M., Kleerebezem, M., Lemos, J. A., Linares, D. M., Ross, P., Stanton, C., et al. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00076-15 · Cited by 914
Müller, A., Wolf, D., & Gutzeit, H. O. (2017) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2017-0030 · Cited by 218
Dintner, S., Staroń, A., Berchtold, E., Petri, T., Mascher, T., & Gebhard, S. (2011) · Journal of Bacteriology · doi:10.1128/jb.05175-11 · Cited by 156
Self-citationIn-Depth Profiling of the LiaR Response of Bacillus subtilis
Wolf, D., Kalamorz, F., Wecke, T., Juszczak, A., Mäder, U., Homuth, G., Jordan, S., Kirstein, J., Hoppert, M., Voigt, B., et al. (2010) · Journal of Bacteriology · doi:10.1128/jb.00543-10 · Cited by 116
Self-citationMunita, J. M., Panesso, D., Diaz, L., Tran, T. T., Reyes, J., Wanger, A., Murray, B. E., & Arias, C. A. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00509-12 · Cited by 118
Bacillithiol is a major buffer of the labile zinc pool in Bacillus subtilis
Ma, Z., Chandrangsu, P., Helmann, T. C., Romsang, A., Gaballa, A., & Helmann, J. D. (2014) · Molecular Microbiology · doi:10.1111/mmi.12794 · Cited by 96
Self-citationHuang, X., Shin, J., Pinochet‐Barros, A., Su, T. T., & Helmann, J. D. (2017) · Molecular Microbiology · doi:10.1111/mmi.13554 · Cited by 93
Self-citationChandrangsu, P., Huang, X., Gaballa, A., & Helmann, J. D. (2019) · Molecular Microbiology · doi:10.1111/mmi.14314 · Cited by 72
Self-citationAntibiotic research in the age of omics: from expression profiles to interspecies communication
Wecke, T., & Mascher, T. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr373 · Cited by 62
Self-citationHecker, M., Reder, A., Fuchs, S., Pagels, M., & Engelmann, S. (2009) · Research in Microbiology · doi:10.1016/j.resmic.2009.03.008 · Cited by 61
de Been, M., Bart, M. J., Abee, T., Siezen, R. J., & Francke, C. (2008) · Environmental Microbiology · doi:10.1111/j.1462-2920.2008.01700.x · Cited by 42
Thevenard, B., Besset, C., Choinard, S., Fourcassié, P., Boyaval, P., Monnet, V., & Rul, F. (2014) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2014.02.011 · Cited by 20
Metadata
- Authors
- Mascher, T., Margulis, N. G., Wang, T., Ye, R. W., & Helmann, J. D.
- Venue
- Molecular Microbiology
- Publisher
- Wiley
- Published
- 2003-11-11
- Volume
- 50
- Issue
- 5
- Pages
- 1591-1604
- ISSN
- 0950-382X (ISSN-L)
- 1365-2958
- OpenAlex
- W2106353887
- Cited by
- 310
- References
- 1
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
