The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.
Effects of pramlintide, an amylin analogue, on gastric emptying in type 1 and 2 diabetes mellitus
Abstract
Pramlintide delays gastric emptying, possibly by a centrally mediated mechanism. Our aim was to determine whether the effects of pramlintide on gastric emptying differ in people with type 1 or type 2 diabetes who had no history of complications. Using a randomized, three-period, two-dose, crossover design, we studied the effects of 0, 30, or 60 microg t.i.d. pramlintide subcutaneously for 5 days each in six type 1 and six type 2 diabetic subjects. Gastric emptying of solids was measured by 13C-Spirulina breath test. Plasma pancreatic polypeptide (HPP) response to the test meal was also measured. Relative to placebo [t 50% 91 +/- 6 min (means +/- SEM)], pramlintide equally delayed gastric emptying following 30 or 60 microg t.i.d. (268 +/- 37 min, 329 +/- 49 min, respectively; P < 0.01]. Postprandial HPP levels were lower in response to 30 and 60 microg pramlintide compared to placebo. There were no significant differences in the effects on gastric emptying or HPP levels between type 1 and type 2 diabetic subjects. Pramlintide delays gastric emptying in diabetes unassociated with clinically detected complications. Further studies are needed in diabetic patients with impaired gastric motor function.
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“Amylin analogs and GLP-1 receptor agonists, particularly short-acting agents, can worsen gastric emptying and should be considered when symptoms arise or deteriorate (Maselli et al., 2021; Vella et al., 2002).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Vella et al., 2002
Citations
Cites
Predicting basal metabolic rate, new standards and review of previous work.
Wn, S. (1985) · PubMed · Cited by 2,955
A Patient Questionnaire to Identify Bowel Disease
Talley, N. J., Phillips, S. F., Melton, L. J., Wiltgen, C., & Zinsmeister, A. R. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-111-8-671 · Cited by 444
Self-citationWilbur, B. G., & Kelly, K. A. (1973) · Annals of Surgery · doi:10.1097/00000658-197309000-00009 · Cited by 285
In vitro autoradiographic localization of amylin binding sites in rat brain
Sexton, P. M., Paxinos, G., Kenney, M. A., Wookey, P. J., & Beaumont, K. C. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90388-3 · Cited by 277
beta-cell apoptosis: stimuli and signaling.
Mandrup-Poulsen, T. R. (2001) · Diabetes · doi:10.2337/diabetes.50.2007.s58 · Cited by 254
Islet Amyloid Polypeptide in Patients with Pancreatic Cancer and Diabetes
Permert, J., Larsson, J., Westermark, G. T., Herrington, M. K., Christmanson, L., Pour, P. M., Westermark, P., & Adrian, T. E. (1994) · New England Journal of Medicine · doi:10.1056/nejm199402033300503 · Cited by 239
Natural history of diabetic gastroparesis.
Kong, M., Horowitz, M., Jones, K. L., Wishart, J. M., & Harding, P. E. (1999) · Diabetes Care · doi:10.2337/diacare.22.3.503 · Cited by 228
High affinity amylin binding sites in rat brain.
Beaumont, K. C., Kenney, M. A., Young, A. A., & RINK, T. J. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13212-4 · Cited by 208
Young, A. A., Gedulin, B. R., Vine, W., Percy, A., & RINK, T. J. (1995) · Diabetologia · doi:10.1007/bf00401833 · Cited by 184
Dose-response for glucagonostatic effect of amylin in rats
Gedulin, B. R., RINK, T. J., & Young, A. A. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90170-0 · Cited by 180
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Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction
Shouman, K., Camilleri, M., & Singer, W. (2026) · Autonomic Neuroscience · doi:10.1016/j.autneu.2026.103474
Self-citationBreath Tests for Assessment of Gastric Emptying
Parkman, H. P., & Szarka, L. A. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-552-1_11
Self-citationMonte, S. V., Schentag, J. J., Adelman, M. H., & Paladino, J. A. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400220
Epidemiology of Type 2 Diabetes in Children and Adolescents
Rosenbloom, A. L. (2007) · CRC Press eBooks · doi:10.3109/9780849379581-25
Bharucha, A. E., & Camilleri, M. (2005) · Elsevier eBooks · doi:10.1016/b978-0-7216-9491-7.50124-1
Self-citationOutpatient vs. Inpatient Gastric Emptying Studies: Does Admission Status Influence Findings?
Holmes, S. L., Kim, M., & Prather, C. M. (2015) · Journal of Hepatology and Gastrointestinal disorders · doi:10.4172/2475-3181.1000103
Vella, A. V. (2021) · Wiley eBooks · doi:10.1002/9781119603207.ch14
Self-citationWelcome, M. O. (2018) · Springer eBooks · doi:10.1007/978-3-319-91056-7_8
Cada, D. J., Levien, T. L., & Baker, D. E. (2005) · Hospital Pharmacy · doi:10.1177/001857870504000709
Diabetic Gastroparesis: Diagnosis, Management, and Future Perspectives
Dołęga, M., Dróżdż, O., Gacka, P., Musialska, D., Gołda, J., Mężyk, J., & Snopkowska, A. (2024) · Quality in Sport · doi:10.12775/qs.2024.19.53973
An AI-enabled dual-hormone model predictive control algorithm that delivers insulin and pramlintide
Jacobs, P. G., Hilts, W. W., Dodier, R. H., LEITSCHUH, J. A., Eom, J. H., Branigan, D. L., Ling, F., Howard, M., MOSQUERA-LOPEZ, C. M., & Wilson, L. M. (2025) · IFAC-PapersOnLine · doi:10.1016/j.ifacol.2025.06.011
Gastric Diseases in Rheumatology
Waseem, A., Pearlstein, E. F., Ayer, D., & Batool, A. (2025) · Clinical gastroenterology · doi:10.1007/978-3-032-07868-1_6
Metadata
- Authors
- VELLA, A., LEE, J. S., CAMILLERI, M., SZARKA, L. A., BURTON, D. D., ZINSMEISTER, A. R., RIZZA, R. A., & KLEIN, P. D.
- Affiliations
- Mayo Clinic (US)
- Nashville State Community College (US)
- Corresponding author
- CAMILLERI, M.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2002-04
- Volume
- 14
- Issue
- 2
- Pages
- 123-131
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W2060927585
- Cited by
- 112
- References
- 41
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 6 · 2012: 3
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mayo Clinic
- Amylin Pharmaceuticals
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK029953, R01-DK29953, R01 DK-54681, K24-DK-02683, R01DK054681)
- National Center for Research Resources (RR-00585, M01RR000585)
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- pramlintide, amylin analogues, gastric emptying, type 1 diabetes, type 2 diabetes, pancreatic polypeptide, postprandial hormone response, gastric motility, subcutaneous administration
- MeSH terms
- Aged, Amyloid, Anti-Ulcer Agents, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Female, Gastric Emptying, Humans, Hypoglycemic Agents, Male, Middle Aged, Linear Models, Cross-Over Studies, Statistics, Nonparametric, Islet Amyloid Polypeptide
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