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Effects of pramlintide, an amylin analogue, on gastric emptying in type 1 and 2 diabetes mellitus
Abstract
Pramlintide delays gastric emptying, possibly by a centrally mediated mechanism. Our aim was to determine whether the effects of pramlintide on gastric emptying differ in people with type 1 or type 2 diabetes who had no history of complications. Using a randomized, three-period, two-dose, crossover design, we studied the effects of 0, 30, or 60 microg t.i.d. pramlintide subcutaneously for 5 days each in six type 1 and six type 2 diabetic subjects. Gastric emptying of solids was measured by 13C-Spirulina breath test. Plasma pancreatic polypeptide (HPP) response to the test meal was also measured. Relative to placebo [t 50% 91 +/- 6 min (means +/- SEM)], pramlintide equally delayed gastric emptying following 30 or 60 microg t.i.d. (268 +/- 37 min, 329 +/- 49 min, respectively; P < 0.01]. Postprandial HPP levels were lower in response to 30 and 60 microg pramlintide compared to placebo. There were no significant differences in the effects on gastric emptying or HPP levels between type 1 and type 2 diabetic subjects. Pramlintide delays gastric emptying in diabetes unassociated with clinically detected complications. Further studies are needed in diabetic patients with impaired gastric motor function.
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“Amylin analogs and GLP-1 receptor agonists, particularly short-acting agents, can worsen gastric emptying and should be considered when symptoms arise or deteriorate (Maselli et al., 2021; Vella et al., 2002).”
From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Vella et al., 2002
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Metadata
- Authors
- VELLA, A., LEE, J. S., CAMILLERI, M., SZARKA, L. A., BURTON, D. D., ZINSMEISTER, A. R., RIZZA, R. A., & KLEIN, P. D.
- Affiliations
- Mayo Clinic (US)
- Nashville State Community College (US)
- Corresponding author
- CAMILLERI, M.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2002-04
- Volume
- 14
- Issue
- 2
- Pages
- 123-131
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W2060927585
- Cited by
- 112
- References
- 41
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 6 · 2012: 3
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mayo Clinic
- Amylin Pharmaceuticals
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK029953, R01-DK29953, R01 DK-54681, K24-DK-02683, R01DK054681)
- National Center for Research Resources (RR-00585, M01RR000585)
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- pramlintide, amylin analogues, gastric emptying, type 1 diabetes, type 2 diabetes, pancreatic polypeptide, postprandial hormone response, gastric motility, subcutaneous administration
- MeSH terms
- Aged, Amyloid, Anti-Ulcer Agents, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Female, Gastric Emptying, Humans, Hypoglycemic Agents, Male, Middle Aged, Linear Models, Cross-Over Studies, Statistics, Nonparametric, Islet Amyloid Polypeptide
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