The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Interdigestive small bowel motility and duodenal bacterial overgrowth in experimental acute pancreatitis
Abstract
Abstract The objective of this study is to investigate the effects of an acute necrotizing pancreatitis (ANP), without biliary obstruction, on the migrating motor complex (MMC), small bowel bacterial overgrowth (SBBO), bacterial translocation (BT) and infection of the pancreas simultaneously. Rats were divided into four groups: mild pancreatitis, control, ANP and sham operated control. Jejunal myoelectrodes were used to measure MMCs. Blood, peritoneal fluid, bile, and abdominal organs were harvested for microbial culturing 72 h after induction of pancreatitis. The splenic portion of the pancreas was taken for histology. During ANP the MMC cycle length was significantly increased from 14.1 ± 0.2 to 22.4 ± 1.9 min (P < 0.05). The duodenum of ANP rats was in contrast with the other groups characterized by Enterobacteriacae (> 3 log 10 CFU g −1 in seven of 12 rats, P < 0.05). A positive correlation (r = 0.78, P < 0.01) existed between duodenal Gram‐negative and anaerobic flora and the MMC cycle. Correlation between MMC cycle length and BT to the pancreas was positive as well (r = 0.70, P < 0.01). A positive correlation (r = 0.85, P < 0.01) was found between the severity of pancreatitis and duodenal bacterial overgrowth. During ANP without biliary obstruction, the jejunal MMC is disturbed and consequently SBBO occurs. The correlation between the severity of pancreatitis, the disturbance of the MMC and SBBO suggests an important pathophysiological role of the proximal small bowel in the infection of pancreatic necrosis.
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In the citing paper
“A reduction in parasympathetically controlled intestinal transit has been associated with an increase in small intestinal bacterial overgrowth and bacterial translocation (Van Felius et al., 2003).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Van Felius et al., 2003
In the citing paper
“Impaired intestinal transit caused by compromised, migrating motor complexes (a motor pattern characteristic of the fasting state of the gastrointestinal tract that is under parasympathetic control), is associated with bacterial overgrowth in the small intestine.20”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [20]
Citations
Cites
A Better Model of Acute Pancreatitis for Evaluating Therapy
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Electrical Spiking Activity and Propulsion in Small Intestine in Fed and Fasted Rats
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The role of infection in acute pancreatitis
Schmid, S. W., Uhl, W., Frieß, H., Malfertheiner, P., & Büchler, M. W. (1999) · Gut · doi:10.1136/gut.45.2.311 · Cited by 226
The role of the gut in the development of sepsis in acute pancreatitis
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182
Gut/brain axis and the microbiota
Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342
“Impaired intestinal transit caused by compromised, migrating motor complexes (a motor pattern characteristic of the fasting state of the gastrointestinal tract that is under parasympathetic control), is associated with bacterial overgrowth in the small intestine”
Martin, C. R., Osadchiy, V., Kalani, A., & Mayer, E. A. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.04.003 · Cited by 1,284
Metadata
- Authors
- Van felius, I. D., Akkermans, L. M. A., Bosscha, K., Verheem, A., Harmsen, W., Visser, M. R., & Gooszen, H. G.
- Affiliations
- University Medical Center Utrecht (NL)
- Corresponding author
- Akkermans, L. M. A.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2003-06
- Volume
- 15
- Issue
- 3
- Pages
- 267-276
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W2019343717
- Cited by
- 134
- References
- 30
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 7 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 7 · 2019: 12 · 2018: 9 · 2017: 8 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 3
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Gallbladder and Bile Duct Disorders
- Keywords
- acute necrotizing pancreatitis, migrating motor complex, small intestinal bacterial overgrowth, bacterial translocation, jejunal motility, Enterobacteriaceae, pancreatitis severity
- MeSH terms
- Animals, Ascitic Fluid, Bile, Blood, Gastrointestinal Motility, Intestine, Small, Male, Pancreas, Myoelectric Complex, Migrating, Bacterial Translocation, Pancreatitis, Acute Necrotizing, Models, Animal, Rats
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