The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Interdigestive small bowel motility and duodenal bacterial overgrowth in experimental acute pancreatitis
Abstract
Abstract The objective of this study is to investigate the effects of an acute necrotizing pancreatitis (ANP), without biliary obstruction, on the migrating motor complex (MMC), small bowel bacterial overgrowth (SBBO), bacterial translocation (BT) and infection of the pancreas simultaneously. Rats were divided into four groups: mild pancreatitis, control, ANP and sham operated control. Jejunal myoelectrodes were used to measure MMCs. Blood, peritoneal fluid, bile, and abdominal organs were harvested for microbial culturing 72 h after induction of pancreatitis. The splenic portion of the pancreas was taken for histology. During ANP the MMC cycle length was significantly increased from 14.1 ± 0.2 to 22.4 ± 1.9 min (P < 0.05). The duodenum of ANP rats was in contrast with the other groups characterized by Enterobacteriacae (> 3 log 10 CFU g −1 in seven of 12 rats, P < 0.05). A positive correlation (r = 0.78, P < 0.01) existed between duodenal Gram‐negative and anaerobic flora and the MMC cycle. Correlation between MMC cycle length and BT to the pancreas was positive as well (r = 0.70, P < 0.01). A positive correlation (r = 0.85, P < 0.01) was found between the severity of pancreatitis and duodenal bacterial overgrowth. During ANP without biliary obstruction, the jejunal MMC is disturbed and consequently SBBO occurs. The correlation between the severity of pancreatitis, the disturbance of the MMC and SBBO suggests an important pathophysiological role of the proximal small bowel in the infection of pancreatic necrosis.
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“A reduction in parasympathetically controlled intestinal transit has been associated with an increase in small intestinal bacterial overgrowth and bacterial translocation (Van Felius et al., 2003).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Van Felius et al., 2003
In the citing paper
“Impaired intestinal transit caused by compromised, migrating motor complexes (a motor pattern characteristic of the fasting state of the gastrointestinal tract that is under parasympathetic control), is associated with bacterial overgrowth in the small intestine.20”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [20]
Citations
Cites
A Better Model of Acute Pancreatitis for Evaluating Therapy
Schmidt, J., Rattner, D. W., Lewandrowski, K. B., Compton, C. C., Mandavilli, U., Knoefel, W. T., & Warshaw, A. L. (1992) · Annals of Surgery · doi:10.1097/00000658-199201000-00007 · Cited by 873
A migrating electric complex of canine small intestine
Szurszewski, J. (1969) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1969.217.6.1757 · Cited by 848
Vantrappen, G., Janssens, J., Hellemans, J., & Ghoos, Y. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108740 · Cited by 815
Windsor, A. C. J., Kanwar, S. S., Li, A. G. K., Barnes, E. J., Guthrie, J. A., Spark, J. I., Welsh, F. K. S., Guillou, P. J., & Reynolds, J. V. (1998) · Gut · doi:10.1136/gut.42.3.431 · Cited by 680
Kalfarentzos, F. E., Kehagias, J., Mead, N., Kokkinis, K., & Gogos, C. A. (1997) · British journal of surgery · doi:10.1046/j.1365-2168.1997.02851.x · Cited by 627
Human interdigestive motility: variations in patterns from esophagus to colon.
Kellow, J., Borody, T., Phillips, S., Tucker, R., & Haddad, A. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90573-1 · Cited by 397
Husebye, E., Hellström, P. M., Sundler, F., Chen, J., & Midtvedt, T. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.3.g368 · Cited by 319
Electrical Spiking Activity and Propulsion in Small Intestine in Fed and Fasted Rats
Ruckebusch, M., & Fioramonti, J. (1975) · Gastroenterology · doi:10.1016/s0016-5085(75)80138-7 · Cited by 273
The role of infection in acute pancreatitis
Schmid, S. W., Uhl, W., Frieß, H., Malfertheiner, P., & Büchler, M. W. (1999) · Gut · doi:10.1136/gut.45.2.311 · Cited by 226
The role of the gut in the development of sepsis in acute pancreatitis
Runkel, N. S. F., Moody, F. G., Smith, G. S., Rodriguez, L. F., LaRocco, M., & Miller, T. A. (1991) · Journal of Surgical Research · doi:10.1016/0022-4804(91)90064-s · Cited by 220
Nieuwenhuijs, V. B., Verheem, A., van Duijvenbode-Beumer, H., Visser, M. R., Verhoef, J., Gooszen, H. G., & Akkermans, L. M. A. (1998) · Annals of Surgery · doi:10.1097/00000658-199808000-00007 · Cited by 186
Self-citationHusebye, E., Skar, V., Høverstad, T., Iversen, T., & Melby, K. K. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90565-0 · Cited by 178
Husebye, E., Hellström, P. M., & Midtvedt, T. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02087542 · Cited by 169
Acute pancreatitis as a model of sepsis
Wilson, P. G., Manji, M., & Neoptolemos, J. P. (1998) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/41.suppl_1.51 · Cited by 143
Enteric mechanisms of initiation of migrating myoelectric complexes in dogs
Sarna, S. K., Condon, R. E., & Cowles, V. E. (1983) · Gastroenterology · doi:10.1016/0016-5085(83)90151-8 · Cited by 133
Intestinal Bacteria Translocate Into Experimental Intra-abdominal Abscesses
Wells, C. L. (1986) · Archives of Surgery · doi:10.1001/archsurg.1986.01400010116016 · Cited by 114
Gastrointestinal motility and gastric tube feeding in mechanically ventilated patients
Bosscha, K. P., Nieuwenhuijs, V. B., Vos, A., Samsom, M., Roelofs, J. M. M., & Akkermans, L. M. A. (1998) · Critical Care Medicine · doi:10.1097/00003246-199809000-00017 · Cited by 102
Self-citationAlterations in intestinal motility and microflora in experimental acute pancreatitis
Leveau, P., Wang, X., Soltesz, V. L., Ihse, I., & Andersson, R. E. (1996) · International Journal of Pancreatology · doi:10.1007/bf02825510 · Cited by 74
Saffar, A. A., Hellstrosm, P. M., & Nylander, G. (1985) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528509089699 · Cited by 59
Intestinal transit and bacterial translocation in obstructive pancreatitis
Moody, F. G., Haley‐Russell, D., & Muncy, D. M. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02212705 · Cited by 55
Hellström, P. M., Al‐Saffar, A., Ljung, T., & Theodorsson, E. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018897028463 · Cited by 50
Obstructive Jaundice, Bacterial Translocation and Interdigestive Small-Bowel Motility in Rats
Nieuwenhuijs, V. B., van Dijk, J. E., Gooszen, H. G., & Akkermans, L. M. A. (2000) · Digestion · doi:10.1159/000007824 · Cited by 37
Self-citationA new clinical prognostic staging system for acute pancreatitis
Rabeneck, L., Feinstein, A. R., Horwitz, R. I., & Wells, C. K. (1993) · The American Journal of Medicine · doi:10.1016/0002-9343(93)90233-f · Cited by 34
Ni, Y., Lukito, G., Marchal, P., Cresens, E., Yu, J., Petré, C., Baert, A. L., & Fevery, J. (1994) · Hepatology · doi:10.1002/hep.1840200627 · Cited by 29
Influence of intestinal myoelectrical activity on the growth of Escherichia coli
Grzesiuk, E., Laubitz, D., Sikora, A., Zabielski, R., & Pierzynowski, S. G. (2001) · Bioelectromagnetics · doi:10.1002/bem.72 · Cited by 18
Disrupted bile flow affects interdigestive small bowel motility in rats
Nieuwenhuijs, V. B., Luiking, Y. C., Verheem, A., Henegouwen, G. P. V. B., Gooszen, H. G., & Akkermans, L. M. A. (1997) · Surgery · doi:10.1016/s0039-6060(97)90134-3 · Cited by 14
Self-citationIntestinal Migrating Myoelectric Complexes in Rats with Acute Pancreatitis and Bile Duct Ligation
Li, Y. F., Newton, T., Weisbrodt, N. W., & Moody, F. G. (1993) · Journal of Surgical Research · doi:10.1006/jsre.1993.1127 · Cited by 12
Inhibition of the migrating motor complex by duodenal drainage in man
NILSSON, I., Svenberg, T., Hedenborg, G., Lördal, M., & Hellström, P. M. (1995) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.1995.tb00206.x · Cited by 8
Automated, quantitative analysis of interdigestive small intestinal myoelectric activity in rats
van Schelven, L. J., Nieuwenhuijs, V. B., & Akkermans, L. M. A. (2002) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2002.00302.x · Cited by 6
Self-citationRieger, H., Runkel, N. S. F., Spröder, J., & Buhr, H. J. (1998) · Springer eBooks · doi:10.1007/978-3-642-72182-3_88 · Cited by 3
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Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182
Gut/brain axis and the microbiota
Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342
“Impaired intestinal transit caused by compromised, migrating motor complexes (a motor pattern characteristic of the fasting state of the gastrointestinal tract that is under parasympathetic control), is associated with bacterial overgrowth in the small intestine”
Martin, C. R., Osadchiy, V., Kalani, A., & Mayer, E. A. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.04.003 · Cited by 1,284
Metadata
- Authors
- Van felius, I. D., Akkermans, L. M. A., Bosscha, K., Verheem, A., Harmsen, W., Visser, M. R., & Gooszen, H. G.
- Affiliations
- University Medical Center Utrecht (NL)
- Corresponding author
- Akkermans, L. M. A.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2003-06
- Volume
- 15
- Issue
- 3
- Pages
- 267-276
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W2019343717
- Cited by
- 134
- References
- 30
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 7 · 2023: 3 · 2022: 4 · 2021: 9 · 2020: 7 · 2019: 12 · 2018: 9 · 2017: 8 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 3
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Gallbladder and Bile Duct Disorders
- Keywords
- acute necrotizing pancreatitis, migrating motor complex, small intestinal bacterial overgrowth, bacterial translocation, jejunal motility, Enterobacteriaceae, pancreatitis severity
- MeSH terms
- Animals, Ascitic Fluid, Bile, Blood, Gastrointestinal Motility, Intestine, Small, Male, Pancreas, Myoelectric Complex, Migrating, Bacterial Translocation, Pancreatitis, Acute Necrotizing, Models, Animal, Rats
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