The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid β from the human brain
Abstract
Accumulation of amyloid β (Aβ) in the extracellular spaces of the cerebral cortex and in blood vessel walls as cerebral amyloid angiopathy is a characteristic of Alzheimer's disease (AD) and the ageing human brain. Studies in animals suggest that Aβ is eliminated from the brain either directly into the blood or along perivascular interstitial fluid drainage channels. The aim of the present study is to define the perivascular route for the drainage of Aβ from the human brain. Smears and paraffin sections of post‐mortem cortical tissue from 17 cases of AD and from two controls were stained with thioflavin and for Aβ by immunohistochemistry. Histology and confocal microscopy showed that deposits of Aβ in the cortical parenchyma were continuous with Aβ in capillary walls but Aβ in artery walls was not in continuity with Aβ in brain parenchyma. Quantitative studies supported these observations. The results of this study suggest that when Aβ is eliminated from the extracellular spaces of the human brain by the perivascular route, it enters pericapillary spaces and from there drains along the walls of cortical arteries to leptomeningeal arteries. Factors such as overproduction of Aβ, entrapment of Aβ in drainage pathways and poor drainage of Aβ due to functional changes in ageing arteries might result in the failure of elimination of Aβ from the ageing brain and play a major role in the pathogenesis of AD. Such factors might affect therapies for AD that entail administration of anti‐Aβ antibodies to eliminate Aβ from the human brain.
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Tarasoff-Conway, J. M., Carare, R. O., Osorio, R. S., Glodzik, L., Butler, T., Fieremans, E., Axel, L., Rusinek, H., Nicholson, C., Zlokovic, B. V., et al. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.119 · Cited by 1,678
Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation
Claassen, J. A. H. R., Thijssen, D. H. J., Panerai, R. B., & Faraci, F. M. (2021) · Physiological Reviews · doi:10.1152/physrev.00022.2020 · Cited by 915
The movers and shapers in immune privilege of the CNS
Engelhardt, B., Vajkoczy, P., & Weller, R. O. (2017) · Nature Immunology · doi:10.1038/ni.3666 · Cited by 893
Self-citationBlood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis
Farrall, A. J., & Wardlaw, J. M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.015 · Cited by 882
A new look at cerebrospinal fluid circulation
Brinker, T., Stopa, E., Morrison, J., & Klinge, P. (2014) · Fluids and Barriers of the CNS · doi:10.1186/2045-8118-11-10 · Cited by 819
Metadata
- Authors
- Preston, S. D., Steart, P. V., Wilkinson, A., Nicoll, J. A. R., & Weller, R. O.
- Venue
- Neuropathology and Applied Neurobiology
- Publisher
- Wiley
- Published
- 2003-03-28
- Volume
- 29
- Issue
- 2
- Pages
- 106-117
- ISSN
- 0305-1846 (ISSN-L)
- 1365-2990
- OpenAlex
- W1496503766
- Cited by
- 239
- References
- 10
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Preston, S. D., Steart, P. V., Wilkinson, A., Nicoll, J. A. R., & Weller, R. O. (2003). Capillary and arterial cerebral amyloid angiopathy in Alzheimer's disease: defining the perivascular route for the elimination of amyloid β from the human brain. Neuropathology and Applied Neurobiology. https://doi.org/10.1046/j.1365-2990.2003.00424.x
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