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The helicase domain of the TMV replicase proteins induces the N‐mediated defence response in tobacco
Open accessAbstract
Summary: Tobacco mosaic virus (TMV) induces the hypersensitive response (HR) in tobacco plants containing the N gene. This defence response is characterized by cell death at the site of virus infection and inhibition of viral replication and movement. A previous study indicated that a portion of the TMV replicase containing a putative helicase domain is involved in HR induction. Here, this observation is confirmed and extended by showing that non‐viral expression of a 50 kDa TMV helicase fragment (p 50) is sufficient to induce the N‐mediated HR in tobacco. Like the HR elicited by TMV infection, transgenic expression of p 50 induces a temperature‐sensitive defence response. We demonstrate that recombinant p 50 protein has ATPase activity, as suggested by the presence of conserved sequence motifs found in ATPase/helicase enzymes. A point mutation that alters one of these motifs abolishes ATPase activity in vitro but does not affect HR induction. These results suggest that features of the TMV helicase domain, independent of its enzymatic activity, are recognized by N‐containing tobacco to induce TMV resistance.
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Cites
Crystal structure of a DExx box DNA helicase
Subramanya, H. S., Bird, L. E., Brannigan, J. A., & Wigley, D. B. (1996) · Nature · doi:10.1038/384379a0 · Cited by 433
Cited by
Liu, Y., Schiff, M., Marathe, R., & Dinesh‐Kumar, S. P. (2002) · The Plant Journal · doi:10.1046/j.1365-313x.2002.01297.x · Cited by 1,042
Thirty years of resistance: Zig-zag through the plant immune system
Ngou, B. P. M., Ding, P., & Jones, J. D. G. (2022) · The Plant Cell · doi:10.1093/plcell/koac041 · Cited by 961
Peart, J. R., Lu, R., Sadanandom, A., Malcuit, I., Moffett, P., Brice, D. C., Schauser, L., Jaggard, D. A. W., Xiao, S., Coleman, M. J., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152330599 · Cited by 422
A Novel Role for the TIR Domain in Association with Pathogen-Derived Elicitors
Burch-Smith, T. M., Schiff, M., Caplan, J. L., Tsao, J., Czymmek, K., & Dinesh-Kumar, S. P. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050068 · Cited by 329
Metadata
- Authors
- Les Erickson, F., Holzberg, S., Calderon‐Urrea, A., Handley, V., Axtell, M., Corr, C., & Baker, B.
- Venue
- The Plant Journal
- Publisher
- Wiley
- Published
- 1999-04
- Volume
- 18
- Issue
- 1
- Pages
- 67-75
- ISSN
- 0960-7412 (ISSN-L)
- 1365-313X
- OpenAlex
- W2124582620
- Cited by
- 229
- References
- 1
- FWCI
- 15.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Les Erickson, F., Holzberg, S., Calderon‐Urrea, A., Handley, V., Axtell, M., Corr, C., & Baker, B. (1999). The helicase domain of the TMV replicase proteins induces the N‐mediated defence response in tobacco. The Plant Journal. https://doi.org/10.1046/j.1365-313x.1999.00426.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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