The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Arabidopsis IRT2 gene encodes a root‐periphery iron transporter
Open accessAbstract
Summary: Iron uptake from the soil is a tightly controlled process in plant roots, involving specialized transporters. One such transporter, IRT1, was identified in Arabidopsis thaliana and shown to function as a broad‐range metal ion transporter in yeast. Here we report the cloning and characterization of the IRT2 cDNA, a member of the ZIP family of metal transporters, highly similar to IRT1 at the amino‐acid level. IRT2 expression in yeast suppresses the growth defect of iron and zinc transport yeast mutants and enhances iron uptake and accumulation. However, unlike IRT1, IRT2 does not transport manganese or cadmium in yeast. IRT2 expression is detected only in roots of A. thaliana plants, and is upregulated by iron deficiency. By fusing the IRT2 promoter to the uidA reporter gene, we show that the IRT2 promoter is mainly active in the external cell layers of the root subapical zone, and therefore provide the first tissue localization of a plant metal transporter. Altogether, these data support a role for the IRT2 transporter in iron and zinc uptake from the soil in response to iron‐limited conditions.
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Cites
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166
The ZIP family of metal transporters
Guerinot, M. L. (2000) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(00)00138-3 · Cited by 1,200
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
Fleming, M. D., Trenor, C. C., Su, M. A., Foernzler, D., Beier, D. R., Dietrich, W. F., & Andrews, N. C. (1997) · Nature Genetics · doi:10.1038/ng0897-383 · Cited by 1,159
Supek, F., Supekova, L., Nelson, H., & Nelson, N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.5105 · Cited by 325
Cited by
IRT1, an Arabidopsis Transporter Essential for Iron Uptake from the Soil and for Plant Growth
Vert, G., Grotz, N., Dédaldéchamp, F., Gaymard, F., Guerinot, M. L., Briat, J.-F., & Curie, C. (2002) · The Plant Cell · doi:10.1105/tpc.001388 · Cited by 1,679
Self-citationPhylogenetic Relationships within Cation Transporter Families of Arabidopsis
Mäser, P., Thomine, S., Schroeder, J. I., Ward, J. M., Hirschi, K., Sze, H., Talke, I. N., Amtmann, A., Maathuis, F. J. M., Sanders, D., et al. (2001) · Plant Physiology · doi:10.1104/pp.126.4.1646 · Cited by 1,257
Iron uptake, trafficking and homeostasis in plants
Hell, R., & Stephan, U. W. (2003) · Planta · doi:10.1007/s00425-002-0920-4 · Cited by 621
Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells
Liuzzi, J. P., Aydemir, F., Nam, H., Knutson, M. D., & Cousins, R. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606424103 · Cited by 577
Iron Transport and Signaling in Plants
Curie, C., & Briat, J.-F. (2003) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.54.031902.135018 · Cited by 570
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Metadata
- Authors
- Vert, G., Briat, J., & Curie, C.
- Venue
- The Plant Journal
- Publisher
- Wiley
- Published
- 2001-04
- Volume
- 26
- Issue
- 2
- Pages
- 181-189
- ISSN
- 0960-7412 (ISSN-L)
- 1365-313X
- OpenAlex
- W1912884694
- Cited by
- 320
- References
- 4
- FWCI
- 19.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vert, G., Briat, J., & Curie, C. (2001). Arabidopsis IRT2 gene encodes a root‐periphery iron transporter. The Plant Journal. https://doi.org/10.1046/j.1365-313x.2001.01018.x
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