The ZIP family of metal transporters
Open accessAbstract
Members of the ZIP gene family, a novel metal transporter family first identified in plants, are capable of transporting a variety of cations, including cadmium, iron, manganese and zinc. Information on where in the plant each of the ZIP transporters functions and how each is controlled in response to nutrient availability may allow the manipulation of plant mineral status with an eye to (1) creating food crops with enhanced mineral content, and (2) developing crops that bioaccumulate or exclude toxic metals.
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In A. halleri, several transporter genes, such as ZIP family members viz. ZIP3, ZIP4, and ZIP6 are responsible for the influx of metal ions from the rhizosphere to roots and are highly expressed due to high copy numbers.
“In A. halleri, several transporter genes, such as ZIP family members viz. ZIP3, ZIP4, and ZIP6 are responsible for the influx of metal ions from the rhizosphere to roots and are highly expressed due to high copy numbers (Guerinot, 2000).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Guerinot, 2000
Section 5.2 (page unavailable) identifies Arabidopsis ZIP3 as a zinc transporter, but says ZIP4 did not confer zinc uptake in yeast and may be chloroplast-targeted. Sections 5.3 and 5.5 discuss transporter expression in other plants and under zinc limitation. The copy does not establish that ZIP3, ZIP4, and ZIP6 mediate uptake from the rhizosphere in A. halleri or that high gene-copy numbers cause their high expression. (LLM, conf=0.88)
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- Authors
- Guerinot, M. L.
- Affiliations
- Dartmouth College (US)
- Corresponding author
- Guerinot, Mary Lou
- ORCID
- Guerinot, Mary Lou
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 2000-05
- Volume
- 1465
- Issue
- 1-2
- Pages
- 190-198
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W2134362016
- Cited by
- 1,200
- References
- 50
- Citations by year
- 2026: 36 · 2025: 47 · 2024: 49 · 2023: 57 · 2022: 74 · 2021: 87 · 2020: 79 · 2019: 57 · 2018: 47 · 2017: 48 · 2016: 47 · 2015: 43 · 2014: 51 · 2013: 40 · 2012: 49
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- U.S. Department of Energy
- U.S. Department of Agriculture
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
- Keywords
- metal transporters, cadmium transport, iron transport, manganese transport, zinc transport, plant mineral nutrition, metal exclusion, biofortification, cation transport
- MeSH terms
- Animals, Biological Transport, Carrier Proteins, Fungal Proteins, Humans, Iron, Manganese, Membrane Proteins, Molecular Sequence Data, Phylogeny, Plant Proteins, Saccharomyces cerevisiae, Zinc, Genes, Plant, Arabidopsis, Cation Transport Proteins, Arabidopsis Proteins, Saccharomyces cerevisiae Proteins
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