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Costs of resistance: genetic correlations and potential trade-offs in an insect immune System
Open accessAbstract
Theory predicts that natural selection will erode additive genetic variation in fitness-related traits. However, numerous studies have found considerable heritable variation in traits related to immune function, which should be closely linked to fitness. This could be due to trade-offs maintaining variation in these traits. We used the Egyptian cotton leafworm, Spodoptera littoralis, as a model system to examine the quantitative genetics of insect immune function. We estimated the heritabilities of several different measures of innate immunity and the genetic correlations between these immune traits and a number of life history traits. Our results provide the first evidence for a potential genetic trade-off within the insect immune system, with antibacterial activity (lysozyme-like) exhibiting a significant negative genetic correlation with haemocyte density, which itself is positively genetically correlated with both haemolymph phenoloxidase activity and cuticular melanization. We speculate on a potential trade-off between defence against parasites and predators, mediated by larval colour, and its role in maintaining genetic variation in traits under natural selection.
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Citations
Cited by
Schneider, D. S., & Ayres, J. S. (2008) · Nature Reviews Immunology · doi:10.1038/nri2432 · Cited by 783
Reproduction–Immunity Trade-Offs in Insects
Schwenke, R. A., Lazzaro, B. P., & Wolfner, M. F. (2016) · Annual Review of Entomology · doi:10.1146/annurev-ento-010715-023924 · Cited by 632
Winter, C., Bouvier, T., Weinbauer, M. G., & Thingstad, T. F. (2010) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00034-09 · Cited by 435
Mating and immunity in invertebrates
LAWNICZAK, M., BARNES, A., LINKLATER, J., BOONE, J., WIGBY, S., & CHAPMAN, T. (2007) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2006.09.012 · Cited by 279
KARL, I., STOKS, R., DE BLOCK, M., JANOWITZ, S. A., & FISCHER, K. (2011) · Global Change Biology · doi:10.1111/j.1365-2486.2010.02277.x · Cited by 161
Metadata
- Authors
- Cotter, S. C., Kruuk, L. E. B., & Wilson, K.
- Venue
- Journal of Evolutionary Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-03-01
- Volume
- 17
- Issue
- 2
- Pages
- 421-429
- ISSN
- 1010-061X (ISSN-L)
- 1420-9101
- OpenAlex
- W2160871932
- Cited by
- 295
- References
- 0
- FWCI
- 13.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Cotter, S. C., Kruuk, L. E. B., & Wilson, K. (2004). Costs of resistance: genetic correlations and potential trade-offs in an insect immune System. Journal of Evolutionary Biology. https://doi.org/10.1046/j.1420-9101.2003.00655.x
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