The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response
Open accessAbstract
Human HtrA2 is a novel member of the HtrA serine protease family and shows extensive homology to the Escherichia coli HtrA genes that are essential for bacterial survival at high temperatures. HumHtrA2 is also homologous to human HtrA1, also known as L56/HtrA, which is differentially expressed in human osteoarthritic cartilage and after SV40 transformation of human fibroblasts. HumHtrA2 is upregulated in mammalian cells in response to stress induced by both heat shock and tunicamycin treatment. Biochemical characterization of humHtrA2 shows it to be predominantly a nuclear protease which undergoes autoproteolysis. This proteolysis is abolished when the predicted active site serine residue is altered to alanine by site‐directed mutagenesis. In human cell lines, it is present as two polypeptides of 38 and 40 kDa. HumHtrA2 cleaves β‐casein with an inhibitor profile similar to that previously described for E. coli HtrA, in addition to an increase in β‐casein turnover when the assay temperature is raised from 37 to 45 °C. The biochemical and sequence similarities between humHtrA2 and its bacterial homologues, in conjunction with its nuclear location and upregulation in response to tunicamycin and heat shock suggest that it is involved in mammalian stress response pathways.
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Metadata
- Authors
- Gray, C. W., Ward, R. V., Karran, E., Turconi, S., Rowles, A., Viglienghi, D., Southan, C., Barton, A., Fantom, K. G., West, A., Savopoulos, J., Hassan, N. J., Clinkenbeard, H., Hanning, C., Amegadzie, B., Davis, J. B., Dingwall, C., Livi, G. P., & Creasy, C. L.
- Venue
- European Journal of Biochemistry
- Publisher
- Wiley
- Published
- 2000-09
- Volume
- 267
- Issue
- 18
- Pages
- 5699-5710
- ISSN
- 0014-2956 (ISSN-L)
- 1432-1033
- OpenAlex
- W2106870473
- Cited by
- 278
- References
- 5
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gray, C. W., Ward, R. V., Karran, E., Turconi, S., Rowles, A., Viglienghi, D., Southan, C., Barton, A., Fantom, K. G., West, A., Savopoulos, J., Hassan, N. J., Clinkenbeard, H., Hanning, C., Amegadzie, B., Davis, J. B., Dingwall, C., Livi, G. P., & Creasy, C. L. (2000). Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. European Journal of Biochemistry. https://doi.org/10.1046/j.1432-1327.2000.01589.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
