The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Early sexual abuse and low cortisol
Open accessAbstract
Abstract Post‐traumatic stress disorder (PTSD) is a mental health disorder precipitated by a stressful event that produces fear or terror in the individual. Post‐traumatic stress disorder studies, particularly in early sexual abuse, have been associated with neuroendocrine dysfunction, most notably the hypothalamic–pituitary–adrenal (HPA) axis. Since the literature on PTSD and neuroendocrine factors in young subjects has been sparse, the present studies were designed to look at the basal functioning of the HPA axis in response to early sexual abuse in girls aged 5 to 7 years. Morning salivary samples were collected for cortisol determination from subjects and controls who were scheduled for a physical exam by their pediatrician. The present study shows that subjects who had been abused within the last couple of months had significantly lower cortisol in comparison to control subjects (age, social economic status and race matched). The data suggest that children may have an impaired HPA axis after early trauma.
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Self-citation
Cited by
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“In contrast, King et al. (2001) found decreased morning cortisol in CSA compared with matched control girls.”
ResultRussell, E., Koren, G., Rieder, M., & Van Uum, S. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.09.009 · Cited by 1,063
“These findings are significant because this was the first time that hair cortisol analysis was used to investigate patients with PTSD, and the results stood in stark contrast to most other studies that have found PTSD to be frequently associated with hypocortisolism (Mason et al., 1986; Yehuda et al., 1996; King et al…”
ResultThe Biological Effects of Childhood Trauma
De Bellis, M. D., & Zisk, A. (2014) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2014.01.002 · Cited by 892
“…that the LHPA system is dysregulated in youth exposed to trauma, the cortisol regulation data seem contradictory, where baseline morning and 24-hour cortisol concentrations showed no differences [39, 40] , were higher [41-47] or in a few studies, lower[47-49] compared to youth without trauma.”
Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms
Yehuda, R., & Lehrner, A. (2018) · World Psychiatry · doi:10.1002/wps.20568 · Cited by 730
Metadata
- Authors
- King, J. A., Mandansky, D., King, S., Fletcher, K. E., & Brewer, J.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- King, Jean A.
- ORCID
- King, Jean A.
- Venue
- Psychiatry and Clinical Neurosciences
- Publisher
- Wiley
- Published
- 2001-02
- Volume
- 55
- Issue
- 1
- Pages
- 71-74
- ISSN
- 1323-1316 (ISSN-L)
- 1440-1819
- OpenAlex
- W2049744963
- Cited by
- 180
- References
- 20
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 6 · 2017: 3 · 2016: 8 · 2015: 9 · 2014: 7 · 2013: 10 · 2012: 18
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychiatry and Clinical Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- eScholarship@UMassChan (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- post-traumatic stress disorder, hypothalamic-pituitary-adrenal axis, cortisol, neuroendocrine dysfunction, children, salivary cortisol, trauma
- MeSH terms
- Child, Child Abuse, Sexual, Child, Preschool, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Stress Disorders, Post-Traumatic
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