The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures
Abstract
Evidence has accumulated that Zn 2+ plays a central role in neurodegenerative processes following brain injuries including ischaemia or epilepsy. In the present study, we examined patterns and possible mechanisms of Zn 2+ neurotoxicity. Inclusion of 30–300 μ m Zn 2+ for 30 min caused neuronal necrosis apparent by cell body and mitochondrial swelling in cortical cell cultures. This Zn 2+ neurotoxicity was not attenuated by antiapoptosis agents, inhibitors of protein synthesis or caspase. Blockade of glutamate receptors or nitric oxide synthase showed no beneficial effect against Zn 2+ neurotoxicity. Interestingly, antioxidants, trolox or SKF38393, attenuated Zn 2+‐induced neuronal necrosis. Pretreatment with insulin or brain‐derived neurotrophic factor increased the Zn 2+‐induced free radical injury. Kainate or AMPA facilitated Zn 2+ entry and potentiated Zn 2+ neurotoxicity in a way sensitive to trolox. Reactive oxygen species and lipid peroxidation were generated in the early phase of Zn 2+ neurotoxicity. These findings indicate that entry and accumulation of Zn 2+ result in generation of toxic free radicals and then cause necrotic neuronal degeneration under certain pathological conditions in the brain.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ankarcrona, M., Dypbukt, J. M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S. A., & Nicotera, P. (1995) · Neuron · doi:10.1016/0896-6273(95)90186-8 · Cited by 1,884
Cited by
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
Que, E. L., Domaille, D. W., & Chang, C. J. (2008) · Chemical Reviews · doi:10.1021/cr078203u · Cited by 2,061
The Essential Toxin: Impact of Zinc on Human Health
Plum, L. M., Rink, L., & Haase, H. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7041342 · Cited by 1,577
Murer, M. G., Yan, Q., & Raisman-Vozari, R. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00014-9 · Cited by 874
Movement of zinc and its functional significance in the brain
Takeda, A. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00044-8 · Cited by 417
Induction of Neuronal Apoptosis by Thiol Oxidation: Putative Role of Intracellular Zinc Release
Aizenman, E., Stout, A. K., Hartnett, K. A., Dineley, K. E., McLaughlin, B., & Reynolds, I. J. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751878.x · Cited by 375
Metadata
- Authors
- Kim, E. Y., Koh, J. Y., Kim, Y. H., Sohn, S., Joe, E., & Gwag, B. J.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 1999-01
- Volume
- 11
- Issue
- 1
- Pages
- 327-334
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2016532781
- Cited by
- 175
- References
- 1
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures. https://app.cochat.ai/papers/10.1046/j.1460-9568.1999.00437.x
- The paper
- Kim, E. Y., Koh, J. Y., Kim, Y. H., Sohn, S., Joe, E., & Gwag, B. J. (1999). Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures. European Journal of Neuroscience. https://doi.org/10.1046/j.1460-9568.1999.00437.x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
