CoChat
Sign Up
Cited by 182Pain Mechanisms and TreatmentsNeuropeptides and Animal PhysiologyNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.

THIS ARTICLE HAS BEEN RETRACTED Repeated massage‐like stimulation induces long‐term effects on nociception: contribution of oxytocinergic mechanisms

Lund, Iréne, Yu, Long‐Chuan, Uvnas‐Moberg, Kerstin, Wang, Jing, Yu, Cheng, Kurosawa, Mieko, Agren, Greta, Rosén, Annika, Lekman, Magnus, Lundeberg, Thomas·2002·European Journal of Neuroscience
DOI 10.1046/j.1460-9568.2002.02087.x
Open this paper in CoChat — free account

Abstract

Massage‐like stroking induces acute antinociceptive effects that can be reversed by an oxytocin antagonist, indicating activation of oxytocin on endogenous pain controlling systems. We now demonstrate an increase in hindpaw withdrawal latencies (HWLs), in response to thermal and mechanical stimuli, which was present after six treatments of massage‐like stroking every other day and which continued to increase through the remaining seven treatments. Repeated massage‐like stroking also resulted in increased oxytocin‐like immunoreactivity (oxytocin‐LI) levels in plasma and periaquaductal grey matter (PAG). Furthermore, increases in HWLs were also present after injections of oxytocin into the PAG (0.1, 0.5 and 1.0 nmol). Intra‐PAG oxytocin injection of 1 nmol followed by 1 or 20 nmol of naloxone attenuated the increments in HWL. Also, there was a dose‐dependent attenuation of the oxytocin‐induced antinociceptive effects following intra‐PAG injection of the µ‐opioid antagonist β‐funaltrexamine (β‐FNA) and the κ‐opioid antagonist nor‐binaltorphimine (nor‐BNI) but not the δ‐antagonist naltrindole. The long‐term antinociceptive effects of massage‐like stroking may be attributed, at least partly, to the oxytocinergic system and its interaction with the opioid system, especially the µ‐ and the κ‐receptors in the PAG.

Overview

Integrity signals

Registry

Crossref · 10.1046/j.1460-9568.2002.02087.xThis paper is marked retracted.

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 41 references

Research works printed but not linked: 6

  1. Fields H.L., 1994, Textbook of Pain, 243
  2. Furlan A.D., 2001, The Cochrane Library
  3. Haldeman S., 1999, Textbook of Pain, 1251
  4. Hansson P., 1999, Textbook of Pain, 951
  5. 10.3412/jsb.37.943 · DOI
  6. Sandkühler J., 2000, Progress in Pain Research and Management Proceedings of the IXth World Congress of Pain, 359

Cited by

Sorted by citations

Items 101–182 of 182

Related

See all

Metadata

Authors
Lund, I., Yu, L., Uvnas‐Moberg, K., Wang, J., Yu, C., Kurosawa, M., Agren, G., Rosén, A., Lekman, M., & Lundeberg, T.
Affiliations
  • Karolinska Institutet (SE)
  • Peking University (CN)
  • International University of Health and Welfare (JP)
  • Karolinska University Hospital (SE)
Corresponding author
Lund, Iréne
ORCID
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2002-07
Volume
16
Issue
2
Pages
330-338
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
DOI
10.1046/j.1460-9568.2002.02087.x
OpenAlex
W2615596569
Cited by
181
References
41
Citations by year
2026: 2 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 10 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 12 · 2014: 13 · 2013: 10 · 2012: 11
FWCI
5.00
Type
journal article
Language
en
Status
Retracted
Update notices
retraction (2009-02-16)
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 39 d)
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords
oxytocin, antinociception, periaqueductal gray, mu-opioid receptor, kappa opioid receptor, opioid system, naloxone, beta-funaltrexamine, nor-binaltorphimine, naltrindole
MeSH terms
Afferent Pathways, Animals, Male, Massage, Mechanoreceptors, Narcotic Antagonists, Nociceptors, Oxytocin, Pain, Periaqueductal Gray, Physical Stimulation, Reaction Time, Time Factors, Rats, Sprague-Dawley, Pain Threshold, Receptors, Opioid, mu, Receptors, Opioid, kappa, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review