The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.
THIS ARTICLE HAS BEEN RETRACTED Repeated massage‐like stimulation induces long‐term effects on nociception: contribution of oxytocinergic mechanisms
Abstract
Massage‐like stroking induces acute antinociceptive effects that can be reversed by an oxytocin antagonist, indicating activation of oxytocin on endogenous pain controlling systems. We now demonstrate an increase in hindpaw withdrawal latencies (HWLs), in response to thermal and mechanical stimuli, which was present after six treatments of massage‐like stroking every other day and which continued to increase through the remaining seven treatments. Repeated massage‐like stroking also resulted in increased oxytocin‐like immunoreactivity (oxytocin‐LI) levels in plasma and periaquaductal grey matter (PAG). Furthermore, increases in HWLs were also present after injections of oxytocin into the PAG (0.1, 0.5 and 1.0 nmol). Intra‐PAG oxytocin injection of 1 nmol followed by 1 or 20 nmol of naloxone attenuated the increments in HWL. Also, there was a dose‐dependent attenuation of the oxytocin‐induced antinociceptive effects following intra‐PAG injection of the µ‐opioid antagonist β‐funaltrexamine (β‐FNA) and the κ‐opioid antagonist nor‐binaltorphimine (nor‐BNI) but not the δ‐antagonist naltrindole. The long‐term antinociceptive effects of massage‐like stroking may be attributed, at least partly, to the oxytocinergic system and its interaction with the opioid system, especially the µ‐ and the κ‐receptors in the PAG.
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“Preclinical studies demonstrate that manipulations involving bodily contact such as massage can induce anti‐nociceptive effects in rodents similar to those elicited by exogenous oxytocin, by triggering the endogenous oxytocin system 86.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [86]
Citations
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Metadata
- Authors
- Lund, I., Yu, L., Uvnas‐Moberg, K., Wang, J., Yu, C., Kurosawa, M., Agren, G., Rosén, A., Lekman, M., & Lundeberg, T.
- Affiliations
- Karolinska Institutet (SE)
- Peking University (CN)
- International University of Health and Welfare (JP)
- Karolinska University Hospital (SE)
- Corresponding author
- Lund, Iréne
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2002-07
- Volume
- 16
- Issue
- 2
- Pages
- 330-338
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2615596569
- Cited by
- 181
- References
- 41
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 10 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 12 · 2014: 13 · 2013: 10 · 2012: 11
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- retraction (2009-02-16)
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- oxytocin, antinociception, periaqueductal gray, mu-opioid receptor, kappa opioid receptor, opioid system, naloxone, beta-funaltrexamine, nor-binaltorphimine, naltrindole
- MeSH terms
- Afferent Pathways, Animals, Male, Massage, Mechanoreceptors, Narcotic Antagonists, Nociceptors, Oxytocin, Pain, Periaqueductal Gray, Physical Stimulation, Reaction Time, Time Factors, Rats, Sprague-Dawley, Pain Threshold, Receptors, Opioid, mu, Receptors, Opioid, kappa, Rats
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