Blockade effect of mu and kappa opioid antagonists on the anti-nociception induced by intra-periaqueductal grey injection of oxytocin in rats
Abstract
Intra-periaqueductal grey (PAG) injection of 1 nmol of oxytocin induced significant increases in hindpaw withdrawal latency (HWL) to thermal and mechanical stimulation in rats. The anti-nociceptive effect of oxytocin was attenuated significantly by subsequent intra-PAG injection of the mu opioid antagonist beta-funaltrexamine (beta-FNA) and the kappa opioid antagonist nor-binaltorphimine (nor-BNI), but not by the delta antagonist naltrindole. The results demonstrated that mu and kappa opioid receptors, not delta receptors, were involved in the oxytocin-induced anti-nociception in PAG of rats.
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Additional mechanisms of oxytocin antinociception involve engagement of endogenous opioid and cannabinoid systems modulating nociception.
“Additional mechanisms involve the engagement of the endogenous opioid 15, 16 and cannabinoid 17 systems modulating nociception.”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [15]
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- Authors
- Ge, Y., Lundeberg, T., & Yu, L.-C.
- Affiliations
- Karolinska Institutet (SE)
- Peking University (CN)
- Corresponding author
- Yu, Long-Chuan
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2002-02
- Volume
- 927
- Issue
- 2
- Pages
- 204-207
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2033034885
- Cited by
- 79
- References
- 18
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 5 · 2019: 3 · 2018: 3 · 2017: 7 · 2016: 5 · 2015: 2 · 2014: 8 · 2013: 3 · 2012: 5
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- oxytocin, antinociception, mu-opioid receptor, kappa opioid receptor, delta opioid receptor, periaqueductal gray, beta-funaltrexamine, nor-binaltorphimine, naltrindole, thermal and mechanical nociception, opioid antagonists
- MeSH terms
- Analgesics, Animals, Injections, Intraventricular, Male, Narcotic Antagonists, Oxytocin, Pain Measurement, Periaqueductal Gray, Rats, Sprague-Dawley, Receptors, Opioid, mu, Receptors, Opioid, kappa, Rats
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