A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease‐relevant insults

Mechanisms Underlying Ubiquitination

Pickart, C. M. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.503 · Cited by 3,731 · see citing works

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

Fenteany, G., Standaert, R. F., Lane, W. S., Choi, S., Corey, E. J., & Schreiber, S. L. (1995) · Science · doi:10.1126/science.7732382 · Cited by 1,583 · see citing works

The tripartite motif family identifies cell compartments

Reymond, A., Meroni, G., Fantozzi, A., Merla, G., Cairo, S., Luzi, L., Riganelli, D., Zanaria, E., Messali, S., Cainarca, S., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.9.2140 · Cited by 1,366 · see citing works

RING Finger Proteins

Joazeiro, C. A. P., & Weissman, A. M. (2000) · Cell · doi:10.1016/s0092-8674(00)00077-5 · Cited by 1,249 · see citing works

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

Lorick, K. L., Jensen, J. P., Fang, S., Ong, A. M., Hatakeyama, S., & Weissman, A. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11364 · Cited by 1,151 · see citing works

The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

Joazeiro, C. A. P., Wing, S. S., Huang, H.-K., Leverson, J. D., Hunter, T. R., & Liu, Y. (1999) · Science · doi:10.1126/science.286.5438.309 · Cited by 1,036 · see citing works

Impaired Proteasome Function in Alzheimer's Disease

Keller, J. N., Hanni, K. B., & Markesbery, W. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750436.x · Cited by 848 · see citing works

Does this have a familiar RING?

Saurin, A. J., Borden, K. L. B., Boddy, M. N., & Freemont, P. S. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)80017-x · Cited by 635 · see citing works

A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ

Hashimoto, Y., Niikura, T., Tajima, H., Yasukawa, T., Sudo, H., Ito, Y., Kita, Y. A., Kawasumi, M., Kouyama, K., Doyu, M., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101133498 · Cited by 624 · see citing works

UBIQUITIN AND THE CONTROL OF PROTEIN FATE IN THE SECRETORY AND ENDOCYTIC PATHWAYS

Bonifacino, J. S., & Weissman, A. M. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.19 · Cited by 607 · see citing works

PML protein isoforms and the RBCC/TRIM motif

Jensen, K., Shiels, C., & Freemont, P. S. (2001) · Oncogene · doi:10.1038/sj.onc.1204765 · Cited by 465 · see citing works

RING domains: master builders of molecular scaffolds?

Borden, K. L. B. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3429 · Cited by 410 · see citing works

Efp targets 14-3-3σ for proteolysis and promotes breast tumour growth

Urano, T., Saito, T., Tsukui, T., Fujita, M., Hosoi, T., Muramatsu, M., Ouchi, Y., & Inoue, S. (2002) · Nature · doi:10.1038/nature00826 · Cited by 357 · see citing works

The RING Finger of c-Cbl Mediates Desensitization of the Epidermal Growth Factor Receptor

Waterman, H., Levkowitz, G., Alroy, I., & Yarden, Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22151 · Cited by 306 · see citing works

MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation

Trockenbacher, A., Suckow, V., Foerster, J., Winter, J., Krauß, S., Ropers, H., Schneider, R., & Schweiger, S. (2001) · Nature Genetics · doi:10.1038/ng762 · Cited by 295 · see citing works

PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR.

Perez, A., Kastner, P., Sethi, S., Lutz, Y., REIBEL, C., & Chambon, P. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05986.x · Cited by 292 · see citing works

The Degradation of Apolipoprotein B100 Is Mediated by the Ubiquitin-proteasome Pathway and Involves Heat Shock Protein 70

Fisher, E. A. A., Zhou, M., Mitchell, D. M., Wu, X., Ōmura, S., Wang, H., Goldberg, A. L., & Ginsberg, H. N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20427 · Cited by 287 · see citing works

RING fingers and B-boxes: zinc-binding protein-protein interaction domains

Borden, K. L. B. (1998) · Biochemistry and Cell Biology · doi:10.1139/bcb-76-2-3-351 · Cited by 228 · see citing works

Defective ubiquitination of cerebral proteins in Alzheimer's disease

Salon, M. L., Morelli, L., Casta�o, E. M., Soto, E. F., & Pasquini, J. M. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20001015)62:2 · Cited by 224 · see citing works

Mechanisms of Neuroprotection by a Novel Rescue Factor Humanin from Swedish Mutant Amyloid Precursor Protein

Hashimoto, Y., Ito, Y., Niikura, T., Shao, Z., Hata, M., Oyama, F., & Nishimoto, I. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4765 · Cited by 223 · see citing works

Detailed Characterization of Neuroprotection by a Rescue Factor Humanin against Various Alzheimer's Disease-Relevant Insults

Hashimoto, Y., Niikura, T., Ito, Y., Sudo, H., Hata, M., Arakawa, E., Abe, Y., Kita, Y. A., & Nishimoto, I. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-23-09235.2001 · Cited by 219 · see citing works

RING fingers and B-boxes: zinc-binding protein-protein interaction domains

Borden, K. L. B. (1998) · Biochemistry and Cell Biology · doi:10.1139/o98-021 · Cited by 214 · see citing works

Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cells.

Platika, D., Boulos, M. H., Baizer, L., & Fishman, M. C. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.10.3499 · Cited by 199 · see citing works

ER-associated and proteasomemediated protein degradation: how two topologically restricted events came together

Brodsky, J. L., & McCracken, A. A. (1997) · Trends in Cell Biology · doi:10.1016/s0962-8924(97)01020-9 · Cited by 185 · see citing works

Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults

Tajima, H., Niikura, T., Hashimoto, Y., Ito, Y., Kita, Y. A., Terashita, K., Yamazaki, K., Koto, A., Aiso, S., & Nishimoto, I. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00199-4 · Cited by 141 · see citing works

The propeptide of macrophage inhibitory cytokine (MIC‐1), a TGF‐β superfamily member, acts as a quality control determinant for correctly folded MIC‐1

Bauskin, A. R., Zhang, H., Fairlie, W. D., He, X. Y., Russell, P. K., Moore, A. G., Brown, D. A., Stanley, K. K., & Breit, S. N. (2000) · The EMBO Journal · doi:10.1093/emboj/19.10.2212 · Cited by 133 · see citing works

An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels

Diamonti, A. J., Guy, P. M., Ivanof, C., Wong, K., Sweeney, C. A., & Carraway, K. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052709799 · Cited by 126 · see citing works

[Gly14]‐Humanin improved the learning and memory impairment induced by scopolamine in vivo

Mamiya, T., & Ukai, M. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704429 · Cited by 113 · see citing works

Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution

Cao, T., Borden, K. L. B., Freemont, P. S., & Etkin, L. D. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.14.1563 · Cited by 107 · see citing works

Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer’s disease-relevant insults

Yamagishi, Y., Hashimoto, Y., Niikura, T., & Nishimoto, I. (2003) · Peptides · doi:10.1016/s0196-9781(03)00106-2 · Cited by 105 · see citing works

Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML

Cao, T., Duprez, E., Borden, K. L. B., Freemont, P. S., & Etkin, L. D. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.10.1319 · Cited by 89 · see citing works

Humanin inhibits cell death of serum-deprived PC12h cells

Kariya, S., Takahashi, N., Ooba, N., Kawahara, M., Nakayama, H., & Ueno, S. (2002) · Neuroreport · doi:10.1097/00001756-200205070-00034 · Cited by 78 · see citing works

A novel rat gene encoding a Humanin‐like peptide endowed with broad neuroprotective activity

Caricasole, A., Bruno, V., Cappuccio, I., Melchiorri, D., Copani, A., & Nicoletti, F. (2002) · The FASEB Journal · doi:10.1096/fj.02-0018fje · Cited by 60 · see citing works

Proparathyroid Hormone-related Protein Is Associated with the Chaperone Protein BiP and Undergoes Proteasome-mediated Degradation

Meerovitch, K., Wing, S. S., & Goltzman, D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.21025 · Cited by 53 · see citing works

Proteasome Contributes to the α‐Secretase Pathway of Amyloid Precursor Protein in Human Cells

Marambaud, P., Chevallier, N., Barelli, H., Wilk, S., & Checler, F. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68020698.x · Cited by 48 · see citing works

Dual Roles of Proteasome in the Metabolism of Presenilin 1

Honda, T., Yasutake, K., Nihonmatsu, N., Mercken, M., Takahashi, H., Murayama, O., Murayama, M., Sato, K., Omori, A., Tsubuki, S., et al. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720255.x · Cited by 48 · see citing works

Finely Tuned Regulation of Cytoplasmic Retention of Xenopus Nuclear Factor 7 by Phosphorylation of Individual Threonine Residues

Shou, W., Li, X., Wu, C. F., Cao, T., Kuang, J., Che, S., & Etkin, L. D. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.990 · Cited by 24 · see citing works

Biosynthesis and Secretion of Parathyroid Hormone Are Sensitive to Proteasome Inhibitors in Dispersed Bovine Parathyroid Cells

Sakwe, A. M., Engström, Å., Larsson, M., & Rask, L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108576200 · Cited by 14 · see citing works

Human genome project: Italian contribution. Future directions

Dulbecco, R. (1997) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199711)173:2 · Cited by 1 · see citing works

TRIM family proteins and their emerging roles in innate immunity

Ozato, K., Shin, D.-M., Chang, T.-H., & Morse, H. (2008) · Nature reviews. Immunology · doi:10.1038/nri2413 · Cited by 1,120 · see citing works

TRIM/RBCC, a novel class of ‘single protein RING finger’ E3 ubiquitin ligases

Meroni, G., & Diez‐Roux, G. (2005) · BioEssays · doi:10.1002/bies.20304 · Cited by 731 · see citing works

Targeting Proteins for Destruction by the Ubiquitin System: Implications for Human Pathobiology

Schwartz, A. L., & Ciechanover, A. J. (2008) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.051208.165340 · Cited by 491 · see citing works

Species-Specific Variation in the B30.2(SPRY) Domain of TRIM5α Determines the Potency of Human Immunodeficiency Virus Restriction

Stremlau, M. H., Perron, M. J., Welikala, S., & Sodroski, J. (2005) · Journal of Virology · doi:10.1128/jvi.79.5.3139-3145.2005 · Cited by 372 · see citing works

Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues

Obulesu, M., & Lakshmi, M. J. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1454-4 · Cited by 290 · see citing works

Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis

Ikonen, M., Liu, B., Hashimoto, Y., Ma, L., Lee, K., Niikura, T., Nishimoto, I., & Cohen, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135111100 · Cited by 279 · see citing works

TRIM E3 Ligases Interfere with Early and Late Stages of the Retroviral Life Cycle

Uchil, P. D., Quinlan, B. D., Chan, W.-T., Luna, J. M., & Mothes, W. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.0040016 · Cited by 241 · see citing works

Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk–lipid droplets

Ogg, S. L., Weldon, A. K., Dobbie, L., Smith, A. J. H., & Mather, I. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402930101 · Cited by 212 · see citing works

The emerging role of the mitochondrial-derived peptide humanin in stress resistance

Yen, K., Lee, C. D., Mehta, H. H., & Cohen, P. (2012) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0203 · Cited by 208 · see citing works

Trim32 is a Ubiquitin Ligase Mutated in Limb Girdle Muscular Dystrophy Type 2H that Binds to Skeletal Muscle Myosin and Ubiquitinates Actin

Kudryashova, E., Kudryashov, D. S., Kramerova, I. A., & Spencer, M. J. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.09.068 · Cited by 207 · see citing works

Structural and functional insights into the B30.2/SPRY domain

Woo, J., Imm, J.-H., Min, C., Kim, K.-J., Cha, S., & Oh, B. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600994 · Cited by 162 · see citing works

Characterization of Endogenous Human Promyelocytic Leukemia Isoforms

Condemine, W., Takahashi, Y., Zhu, J., Puvion-Dutilleul, F., Guégan, S., Janin, A., & de Thé, H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3792 · Cited by 155 · see citing works

Mitochondrial stress signaling in longevity: A new role for mitochondrial function in aging

Hill, S., & Remmen, H. V. (2014) · Redox Biology · doi:10.1016/j.redox.2014.07.005 · Cited by 129 · see citing works

A Specific Region of 37 Amino Acid Residues in the SPRY (B30.2) Domain of African Green Monkey TRIM5α Determines Species-Specific Restriction of Simian Immunodeficiency Virus SIVmac Infection

Nakayama, E. E., Miyoshi, H., Nagai, Y., & Shioda, T. (2005) · Journal of Virology · doi:10.1128/jvi.79.14.8870-8877.2005 · Cited by 124 · see citing works

Evidence for potential functionality of nuclearly-encoded humanin isoforms

Bodzioch, M., Lapicka-Bodzioch, K., Zapała, B., Kamysz, W., Kieć‐Wilk, B., & Dembinska-Kiec, A. (2009) · Genomics · doi:10.1016/j.ygeno.2009.05.006 · Cited by 123 · see citing works

Intracellular Origin of Milk Fat Globules and the Nature of the Milk Fat Globule Membrane

Keenan, T. W., & Mather, I. H. (2007) · Springer eBooks · doi:10.1007/0-387-28813-9_4 · Cited by 117 · see citing works

Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin–proteosome systemPreprint

Tuoc, T., & Stoykova, A. (2008) · Genes & Development · doi:10.1101/gad.471708 · Cited by 115 · see citing works

Functional interactions between ubiquitin E2 enzymes and TRIM proteins

Napolitano, L. M. R., Jaffray, E., Hay, R. T., & Meroni, G. (2011) · Biochemical Journal · doi:10.1042/bj20101487 · Cited by 111 · see citing works

APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer’s disease

Vélez, J. I., Lopera, F., Sepulveda-Falla, D., Patel, H. R., Johar, A. S., Chuah, A., Tobón, C., Rivera, D., Villegas, A., Cai, Y., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.177 · Cited by 111 · see citing works

Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer’s disease-relevant insults

Yamagishi, Y., Hashimoto, Y., Niikura, T., & Nishimoto, I. (2003) · Peptides · doi:10.1016/s0196-9781(03)00106-2 · Cited by 105 · see citing works

Humanin and Age-Related Diseases: A New Link?

Gong, Z., Tas, E., & Muzumdar, R. H. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00210 · Cited by 102 · see citing works

Trim Proteins as Ring Finger E3 Ubiquitin Ligases

Ikeda, K., & Inoue, S. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5398-7_3 · Cited by 99 · see citing works

Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases

Cai, H., Liu, Y., Men, H., & Zheng, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.683151 · Cited by 90 · see citing works

TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase.

Kallijärvi, J., Lahtinen, U., Hämäläinen, R., Lipsanen-Nyman, M., Palvimo, J., & Lehesjoki, A. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.04.001 · Cited by 103 · see citing works

Contribution of E3-Ubiquitin Ligase Activity to HIV-1 Restriction by TRIM5α rh : Structure of the RING Domain of TRIM5α

Lienlaf, M., Hayashi, F., Nunzio, F. D., Tochio, N., Kigawa, T., Yokoyama, S., & Diaz‐Griffero, F. (2011) · Journal of Virology · doi:10.1128/jvi.00497-11 · Cited by 86 · see citing works

Cutaneous Melanocytoma With CRTC1-TRIM11 Fusion

Cellier, L., Perron, É., Pissaloux, D., Karanian, M., Haddad, V., Alberti, L., & de la Fouchardière, A. (2017) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000996 · Cited by 80 · see citing works

The Ubiquitin System in Alzheimer’s Disease

Harris, L. D., Jasem, S., & Licchesi, J. D. F. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-38266-7_8 · Cited by 76 · see citing works

Unravelling the role of Humanin

Nishimoto, I., Matsuoka, M., & Niikura, T. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.01.001 · Cited by 77 · see citing works

Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease‐related neurotoxicity: functional potentiation by isomerization and dimerization

Terashita, K., Hashimoto, Y., Niikura, T., Tajima, H., Yamagishi, Y., Ishizaka, M., Kawasumi, M., Chiba, T., Kanekura, K., Yamada, M., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01797.x · Cited by 75 · see citing works

Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer’s disease

Delgado‐Peraza, F., Nogueras‐Ortiz, C. J., Simonsen, A. H., Knight, D. D., Yao, P. J., Goetzl, E. J., Jensen, C. S., Høgh, P., Gottrup, H., Vestergaard, K., et al. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01303-9 · Cited by 74 · see citing works

TRIM11, a direct target of miR-24-3p, promotes cell proliferation and inhibits apoptosis in colon cancer

Yin, Y., Zhong, J., Li, S., Li, J., Zhou, M., Chen, Y., Sang, Y., & Liu, L. (2016) · Oncotarget · doi:10.18632/oncotarget.13550 · Cited by 74 · see citing works

Modulation of Retroviral Restriction and Proteasome Inhibitor-Resistant Turnover by Changes in the TRIM5α B-Box 2 Domain

Diaz‐Griffero, F., Kar, A. K., Perron, M. J., Xiang, S.-H., Javanbakht, H., Li, X., & Sodroski, J. (2007) · Journal of Virology · doi:10.1128/jvi.00703-07 · Cited by 72 · see citing works

TRIM11 is overexpressed in high-grade gliomas and promotes proliferation, invasion, migration and glial tumor growth

Di, K., Linskey, M. E., & Bota, D. A. (2012) · Oncogene · doi:10.1038/onc.2012.531 · Cited by 71 · see citing works

Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties

Zapała, B., Kaczyński, Ł., Kieć‐Wilk, B., Staszel, T., Knapp, A., Thoresen, G. H., Wybrańska, I., & Dembinska-Kiec, A. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70337-6 · Cited by 70 · see citing works

Biochemical and Biophysical Characterization of a Chimeric TRIM21-TRIM5α Protein

Kar, A. K., Diaz‐Griffero, F., Li, Y., Li, X., & Sodroski, J. (2008) · Journal of Virology · doi:10.1128/jvi.01559-08 · Cited by 70 · see citing works

TRIM32 Protein Sensitizes Cells to Tumor Necrosis Factor (TNFα)-induced Apoptosis via Its RING Domain-dependent E3 Ligase Activity against X-linked Inhibitor of Apoptosis (XIAP)

Ryu, Y. S., Lee, Y., Lee, K. W., Hwang, C. Y., Maeng, J., Kim, J., Seo, Y., You, K., Song, B., & Kwon, K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.241893 · Cited by 67 · see citing works

A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation

Liu, Q., Lei, J. X., Sikorska, M., & Liu, R. (2008) · Molecular Neurodegeneration · doi:10.1186/1750-1326-3-4 · Cited by 66 · see citing works

The Role of Ubiquitin-Protein Ligases in Neurodegenerative Disease

Ardley, H. C., & Robinson, P. A. (2004) · Neurodegenerative Diseases · doi:10.1159/000080048 · Cited by 66 · see citing works

TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process

Lee, S. S., Fu, N. Y., Sukumaran, S. K., Wan, K. F., Wan, Q., & Yu, V. C. K. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.11.021 · Cited by 59 · see citing works

High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men

Woodhead, J. S. T., D’Souza, R. F., Hedges, C. P., Wan, J., Berridge, M. V., Cameron-Smith, D., Cohen, P., Hickey, A. J. R., Mitchell, C. J., & Merry, T. L. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00032.2020 · Cited by 57 · see citing works

Distinct Expression of Long Non-Coding RNAs in an Alzheimer's Disease Model

Lee, D. Y., Moon, J., Lee, S., Jung, K., Park, D.-K., Yoo, J.-S., Sunwoo, J., Byun, J., Shin, J.-W., Jeon, D., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142919 · Cited by 56 · see citing works

Tumor suppressor p53 cross-talks with TRIM family proteins

Liu, J., Zhang, C., Wang, X. B., Hu, W., & Feng, Z. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.07.003 · Cited by 55 · see citing works

Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology

Lee, Y., Huang, W., Lin, J.-H., Kao, T., Lin, H., Lee, K., Lin, H.-C., Shen, C.-K. J., Chang, W., & Huang, C. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0479-4 · Cited by 50 · see citing works

TRIM11 Negatively Regulates IFNβ Production and Antiviral Activity by Targeting TBK1

Lee, Y., Song, B., Park, C., & Kwon, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063255 · Cited by 49 · see citing works

Humanin: After the Discovery

Niikura, T., Chiba, T., Aiso, S., Matsuoka, M., & Nishimoto, I. (2004) · Molecular Neurobiology · doi:10.1385/mn:30:3:327 · Cited by 49 · see citing works

Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases

Zuccato, C. F., Asad, A. S., Candia, A. J. N., Gottardo, M. F., Ayala, M. A. M., Theas, M. S., Seilicovich, A., & Candolfi, M. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1559300 · Cited by 48 · see citing works

Environmental monitoring of Domingo Rubio stream (Huelva Estuary, SW Spain) by combining conventional biomarkers and proteomic analysis in Carcinus maenas

Montes‐Nieto, R., García‐Barrera, T., Gómez‐Ariza, J. L., & López‐Barea, J. (2009) · Environmental Pollution · doi:10.1016/j.envpol.2009.09.005 · Cited by 44 · see citing works

Tripartite motif-containing 3 (TRIM3) inhibits tumor growth and metastasis of liver cancer

Huang, X., Zhang, X.-F., Xia, J.-H., Chao, J., Pan, Q., Zhao, J., Zhou, Z.-Q., Chen, C.-L., Tang, Y., Weng, D., et al. (2017) · 癌症：英文版 · doi:10.1186/s40880-017-0240-5 · Cited by 43 · see citing works

The Molecular Structure and Role of Humanin in Neural and Skeletal Diseases, and in Tissue Regeneration

Zhu, S., Hu, X., Bennett, S., Xu, J., & Mai, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.823354 · Cited by 42 · see citing works

Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer

Ayala, M. A. M., Gottardo, M. F., Zuccato, C. F., Pidre, M. L., Candia, A. J. N., Asad, A. S., Imsen, M., Romanowski, V., Cretón, A., Larrain, M. I., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-65381-7 · Cited by 41 · see citing works

Emerging Roles of Tripartite Motif-Containing Family Proteins (TRIMs) in Eliminating Misfolded Proteins

Zhang, L., Afolabi, L. O., Wan, X., Li, Y., & Chen, L. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00802 · Cited by 40 · see citing works

Humanin: Functional Interfaces with IGF-I

Xiao, J., Kim, S.-J., Cohen, P., & Yen, K. (2016) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2016.03.005 · Cited by 41 · see citing works

Proliferation and invasion of ovarian cancer cells are suppressed by knockdown of TRIM11

Chen, Y., Sun, J., & Ma, J. (2017) · Oncology Letters · doi:10.3892/ol.2017.6432 · Cited by 40 · see citing works

Upregulated TRIM11 Exerts its Oncogenic Effects in Hepatocellular Carcinoma Through Inhibition of P53

Liu, J., Rao, J., Lou, X., Zhai, J., Ni, Z., & Wang, X. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000484678 · Cited by 40 · see citing works

VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin

Rossini, L., Hashimoto, Y., Suzuki, H., Kurita, M., Gianfriddo, M., Scali, C., Roncarati, R., Franceschini, D., Pollio, G., Trabalzini, L., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-163535 · Cited by 39 · see citing works

Roles of the ubiquitin-proteosome system in neurogenesis

Tuoc, T., & Stoykova, A. (2010) · Cell Cycle · doi:10.4161/cc.9.16.12551 · Cited by 37 · see citing works

Common disease signatures from gene expression analysis in Huntington’s disease human blood and brain

Mina, E., van Roon‐Mom, W., Hettne, K. M., van Zwet, E. W., Goeman, J. J., Néri, C., Hoen, P. A. C. ’., Mons, B., & Roos, M. (2016) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-016-0475-2 · Cited by 36 · see citing works

Strategies for the identification of ubiquitin ligase inhibitors

Goldenberg, S. J., Marblestone, J. G., Mattern, M. R., & Nicholson, B. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380132 · Cited by 36 · see citing works

Role of TRIM5α RING Domain E3 Ubiquitin Ligase Activity in Capsid Disassembly, Reverse Transcription Blockade, and Restriction of Simian Immunodeficiency Virus

Kim, J., Tipper, C. H., & Sodroski, J. (2011) · Journal of Virology · doi:10.1128/jvi.00341-11 · Cited by 35 · see citing works

High expression of TRIM11 correlates with poor prognosis in patients with hepatocellular carcinoma

Chen, Y., Li, L., Qian, X., Ge, Y., & Xu, G. (2017) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2016.09.010 · Cited by 33 · see citing works

Humanin and Alzheimer's disease: The beginning of a new field

Niikura, T. (2021) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2021.130024 · Cited by 34 · see citing works

TRIM11 binds to and destabilizes a key component of the activator‐mediated cofactor complex (ARC105) through the ubiquitin–proteasome system

Ishikawa, H., Tachikawa, H., Miura, Y., & Takahashi, N. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.07.066 · Cited by 32 · see citing works

Protective Effects of Humanin and Calmodulin-Like Skin Protein in Alzheimer’s Disease and Broad Range of Abnormalities

Matsuoka, M. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8799-1 · Cited by 29 · see citing works

Expression of Tripartite Motif-Containing Proteactiin 11 (TRIM11) is Associated with the Progression of Human Prostate Cancer and is Downregulated by MicroRNA-5193

Pan, Y., Zhang, R., Chen, H., Chen, W., Ke-ming, W., & Lv, J. (2019) · Medical Science Monitor · doi:10.12659/msm.911818 · Cited by 29 · see citing works

Loss of the novel tumour suppressor and polarity gene Trim62 ( Dear1 ) synergizes with oncogenic Ras in invasive lung cancer

Quintás‐Cardama, A., Post, S. M., Solis, L. M., Xiong, S., Yang, P., Chen, N., Wistuba, I. I., Killary, A. M., & Lozano, G. (2014) · The Journal of Pathology · doi:10.1002/path.4385 · Cited by 27 · see citing works

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation in vitro and in vivo

Wang, L., Wu, J., Yuan, J. X., Zhu, X., Wu, H., & Li, M. (2016) · Frontiers of Medicine · doi:10.1007/s11684-016-0429-z · Cited by 27 · see citing works

Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c)

Yoon, T. K., Lee, C. H., Kwon, O., & Kim, M. (2022) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2022.0092 · Cited by 27 · see citing works

Neuroprotection against neurodegenerative diseases

Chiba, T., Nishimoto, I., Aiso, S., & Matsuoka, M. (2007) · Molecular Neurobiology · doi:10.1007/bf02700624 · Cited by 27 · see citing works

Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors

Gottardo, M. F., Pidre, M. L., Zuccato, C. F., Asad, A. S., Imsen, M., Jaita, G., Candolfi, M., Romanowski, V., & Seilicovich, A. (2018) · APOPTOSIS · doi:10.1007/s10495-018-1444-0 · Cited by 26 · see citing works

Mitochondrial-derived peptides and exercise

Woodhead, J. S. T., & Merry, T. L. (2021) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2021.130011 · Cited by 27 · see citing works

Tripartite motif‐containing protein 11 promotes hepatocellular carcinogenesis through ubiquitin‐proteasome–mediated degradation of pleckstrin homology domain leucine‐rich repeats protein phosphatase 1

Yang, J., Ye, J., Ma, T., Tang, F., Huang, L., Liu, Z., Tian, S., Cheng, X., Zhang, L., Guo, Z., et al. (2021) · Hepatology · doi:10.1002/hep.32234 · Cited by 26 · see citing works

Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer’s disease models via the heterotrimeric Humanin receptor

Hashimoto, Y., Nawa, M., Kurita, M., Tokizawa, M., Iwamatsu, A., & Matsuoka, M. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.80 · Cited by 25 · see citing works

Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin

Hashimoto, Y., Terashita, K., Niikura, T., Yamagishi, Y., Ishizaka, M., Kanekura, K., Chiba, T., Yamada, M., Kita, Y. A., Aiso, S., et al. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03298.x · Cited by 23 · see citing works

The E3 ubiquitin ligase TRIM11 mediates the degradation of congenital central hypoventilation syndrome-associated polyalanine-expanded PHOX2B

Parodi, S., Zanni, E. D., Lascio, S. D., Bocca, P., Prigione, I., Fornasari, D., Pennuto, M., Bachetti, T., & Ceccherini, I. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0868-1 · Cited by 22 · see citing works

Trim11 increases expression of dopamine β-hydroxylase gene by interacting with Phox2b

Hong, S. J., Chae, H., Lardaro, T., Hong, S., & Kim, K. S. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.01.165 · Cited by 22 · see citing works

A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11

Cooper, S. T., & Hanson, I. M. (2005) · BMC Genetics · doi:10.1186/1471-2156-6-43 · Cited by 21 · see citing works

Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer’s disease

Benaki, D. C., Zikos, C. C., Evangelou, A., Livaniou, E., Vlassi, M., Mikros, E., & Pelecanou, M. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.08.087 · Cited by 21 · see citing works

Many Faces of TRIM Proteins on the Road from Pluripotency to Neurogenesis

Nenasheva, V. V., & Tarantul, V. Z. (2019) · Stem Cells and Development · doi:10.1089/scd.2019.0152 · Cited by 20 · see citing works

TRIM66 expression in non-small cell lung cancer: A new predictor of prognosis

Ma, Y., Dai, H., Zhang, F., & Zhao, D. (2017) · Cancer Biomarkers · doi:10.3233/cbm-170207 · Cited by 17 · see citing works

SUMOylation of MCL1 protein enhances its stability by regulating the ubiquitin-proteasome pathway

Li, S., Wang, J., Hu, G., Aman, S., Li, B., Li, Y., Xia, K., Yang, Y., Ahmad, B., Wang, M., et al. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109686 · Cited by 17 · see citing works

FBXL21 association with schizophrenia in irish family and case–control samples

Chen, X., Wang, X., Sun, C., Chen, Q., O’Neill, F. A., Walsh, D., Fanous, A. H., & Kendler, K. S. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30759 · Cited by 17 · see citing works

Mitochondrial-derived peptides: Antidiabetic functions and evolutionary perspectives

Kal, S., Mahata, S., Jati, S., & Mahata, S. K. (2023) · Peptides · doi:10.1016/j.peptides.2023.171147 · Cited by 14 · see citing works

The Human Antiviral Factor TRIM11 Is under the Regulation of HIV-1 Vpr

Yuan, T., Yao, W., Huang, F., Sun, B., & Yang, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104269 · Cited by 13 · see citing works

Humanin Structural Versatility and Interaction with Model Cerebral Cortex Membranes

Pistolesi, S., Rossini, L., Ferro, E., Basosi, R., Trabalzini, L., & Pogni, R. (2009) · Biochemistry · doi:10.1021/bi900187s · Cited by 13 · see citing works

High‐yield, solid‐phase synthesis of humanin, an Alzheimer's disease associated, novel 24‐mer peptide which contains a difficult sequence

Evangelou, A., Zikos, C. C., Livaniou, E., & Evangelatos, G. P. (2004) · Journal of Peptide Science · doi:10.1002/psc.572 · Cited by 13 · see citing works

Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide

Kigawa, A., Wakui, H., Maki, N., Okuyama, S., Masai, R., Ohtani, H., Komatsuda, A., Suzuki, D., Toyoda, M., Kobayashi, R., et al. (2004) · Clinical and Experimental Nephrology · doi:10.1007/s10157-004-0322-y · Cited by 11 · see citing works

Tripartite Motif Containing 11 Interacts with DUSP6 to Promote the Growth of Human Osteosarcoma Cells through Regulating ERK1/2 Pathway

Wang, Z., Xu, X., Tang, W., Zhu, Y., Hu, J., & Zhang, X. (2019) · BioMed Research International · doi:10.1155/2019/9612125 · Cited by 10 · see citing works

Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis

Giannopoulou, A.-I., Xanthopoulos, C., Piperi, C., & Kostareli, E. (2022) · Cancers · doi:10.3390/cancers14184536 · Cited by 10 · see citing works

Therapeutic, diagnostic and prognostic values of TRIM proteins in prostate cancer

Li, X., Bai, Y., Feng, K., Chu, Z., Li, H., Lin, Z., & Lin, T. (2023) · Pharmacological Reports · doi:10.1007/s43440-023-00534-9 · Cited by 9 · see citing works

Bioinformatics gene analysis for potential biomarkers and therapeutic targets of Parkinson’s disease based on neutrophil extracellular traps

Wang, Q., Gu, Y., Liu, X., Wang, Q., Xie, C., & Wang, X. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1388226 · Cited by 8 · see citing works

Sequence Variant in the TRIM39-RPP21 Gene Readthrough is Shared Across a Cohort of Arabian Foals Diagnosed with Juvenile Idiopathic Epilepsy.

Polani, S., Dean, M. C., Lichter-Peled, A., Hendrickson, S. L., Tsang, S. X., Fang, X., Feng, Y., Qiao, W., Avni, G., & Bar‐Gal, G. K. (2022) · PubMed · Cited by 8 · see citing works

Humanin binds MPP8: mapping interaction sites of the peptide and protein

Maximov, V. V., Martynenko, A. V., Arman, I. P., & Tarantul, V. Z. (2013) · Journal of Peptide Science · doi:10.1002/psc.2500 · Cited by 8 · see citing works

Cloning and characterization of a novel humanSPRYD4gene encoding a putative SPRY domain-containing protein

Zhong, Z., Zhang, H., Bai, M., Ni, J., Wan, B., Chen, X., & Yu, L. (2008) · DNA sequence · doi:10.1080/10425170701433101 · Cited by 7 · see citing works

SUMO1 modification of 0N4R-tau is regulated by PIASx, SENP1, SENP2, and TRIM11

Wada, H., Maruyama, T., & Niikura, T. (2024) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2024.101800 · Cited by 7 · see citing works

Gene fusion–driven cutaneous mesenchymal neoplasms: An updated review emphasizing the emerging entities

Cazzato, G., Fortarezza, F., Daruish, M., Annese, T., Ribatti, D., Ingravallo, G., Mura, M. D., Sorino, J., Tos, A. P. D., Giubellino, A., et al. (2026) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-025-04394-x · Cited by 6 · see citing works

Structure of three Humanin peptides with different activities upon interaction with liposome

Hirano, A., Shiraki, K., Niikura, T., Arakawa, T., & Kita, Y. A. (2011) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2010.12.017 · Cited by 6 · see citing works

Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system

Maximov, V. V., Arman, I. P., & Tarantul, V. Z. (2006) · Russian Journal of Genetics · doi:10.1134/s1022795406020141 · Cited by 5 · see citing works

Structure changes of natively disordered Humanin in the presence of lipid

Hirano, A., Shiraki, K., Niikura, T., Arakawa, T., & Kita, Y. A. (2010) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2010.01.012 · Cited by 5 · see citing works

Humanin: a potential peptide for neuroprotective therapy against Alzheimer's disease

Niikura, T. (2007) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2.9.1273 · Cited by 6 · see citing works

Humanin and Alzheimer's disease: The beginning of a new field

Niikura, T. (2021) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2021.130024 · Cited by 34 · see citing works

Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer’s disease-relevant insults

Yamagishi, Y., Hashimoto, Y., Niikura, T., & Nishimoto, I. (2003) · Peptides · doi:10.1016/s0196-9781(03)00106-2 · Cited by 105 · see citing works

A Humanin Derivative Reduces Amyloid Beta Accumulation and Ameliorates Memory Deficit in Triple Transgenic Mice

Niikura, T., Sidahmed, E., Hirata‐Fukae, C., Aisen, P. S. S., & Matsuoka, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016259 · Cited by 76 · see citing works

A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice, PloS One 6 (2011) e16259. http://dx.doi.org

Niikura, T., Sidahmed, E., Hirata‐Fukae, C., Aisen, P. S., & Matsuoka, Y. (2016)