High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men
Open accessAbstract
Small regulatory peptides encoded within the mitochondrial genome (mitochondrial derived peptides) have been shown to have cellular cyto- and metabolo-protective roles that parallel those of exercise. Here we provide evidence that humanin and SHLP6 are exercise-sensitive mitochondrial derived peptides. Studies to determine whether mitochondrial derived peptides play a role in regulating exercise-induced adaptations are warranted.
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Exercise has been shown to increase the expression of Humanin and SHLP6, exerting anti-inflammatory, insulin-sensitizing, and metabolic regulatory effects.
“In humans, exercise has been shown to increase the expression of Humanin and SHLP6, exerting anti-inflammatory, insulin-sensitizing, and metabolic regulatory effects [77,78].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [77]
The Results and Discussion (page unavailable) report that acute exercise increased humanin abundance in muscle and plasma and appeared to raise plasma SHLP6 transiently in young men. They do not show that these exercise-induced changes exert anti-inflammatory, insulin-sensitizing, or metabolic-regulatory effects; the Introduction discusses insulin sensitivity following exogenous humanin treatment in rodents, and short-term training lowered rather than raised absolute plasma SHLP6. (LLM, conf=0.89)
Experimental — accuracy not yet measuredAge may influence responses; some studies suggest that older adults show blunted irisin responses to training compared with younger populations.
“Age may also influence responses; some studies suggest that older adults show blunted irisin responses to training compared with younger populations [40,77].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [77]
The Discussion (page unavailable) compares exercise-related humanin findings in older men with those in a younger cohort, but it does not address irisin. Searches for irisin and age-related exercise responses found no passage reporting blunted irisin responses to training in older adults. (LLM, conf=0.77)
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Cites
Tissue-based map of the human proteome
Uhlén, M., Fagerberg, L., Hallström, B. M., Lindskog, C., Oksvold, P., Mardinoglu, A., Sivertsson, Å., Kampf, C., Sjöstedt, E., Asplund, A., et al. (2015) · Science · doi:10.1126/science.1260419 · Cited by 15,286 · see citing works
Sequence and organization of the human mitochondrial genome
Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H. L., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich, D. P., Roe, B. A., Sanger, F., et al. (1981) · Nature · doi:10.1038/290457a0 · Cited by 9,640 · see citing works
Percutaneous Needle Biopsy of Skeletal Muscle in Physiological and Clinical Research
Bergström, J. P. (1975) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517509095787 · Cited by 1,159 · see citing works
Integrative Biology of Exercise
Hawley, J. A., Hargreaves, M., Joyner, M. J., & Zierath, J. R. (2014) · Cell · doi:10.1016/j.cell.2014.10.029 · Cited by 1,152 · see citing works
Lee, C., Zeng, J., Drew, B. G., Sallam, T., Martin-Montalvo, A., Wan, J., Kim, S.-J., Mehta, H., Hevener, A. L., de Cabo, R., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.02.009 · Cited by 715 · see citing works
Self-citationMaintenance and Expression of Mammalian Mitochondrial DNA
Gustafsson, C. M., Falkenberg, M., & Larsson, N. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014402 · Cited by 688 · see citing works
Hashimoto, Y., Niikura, T., Tajima, H., Yasukawa, T., Sudo, H., Ito, Y., Kita, Y. A., Kawasumi, M., Kouyama, K., Doyu, M., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101133498 · Cited by 624 · see citing works
Humanin peptide suppresses apoptosis by interfering with Bax activation
Guo, B., Zhai, D., Cabezas, E., Welsh, K., Nouraini, S., Satterthwait, A. C., & Reed, J. C. (2003) · Nature · doi:10.1038/nature01627 · Cited by 619 · see citing works
Mitochondria as signaling organelles
Chandel, N. S. (2014) · BMC Biology · doi:10.1186/1741-7007-12-34 · Cited by 576 · see citing works
Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training?
Merry, T. L., & Ristow, M. (2015) · The Journal of Physiology · doi:10.1113/jp270654 · Cited by 326 · see citing works
Cobb, L. J., Lee, C. D., Xiao, J., Yen, K., Wong, R. G., Nakamura, H. K., Mehta, H. H., Gao, Q., Ashur, C., Huffman, D. M., et al. (2016) · Aging · doi:10.18632/aging.100943 · Cited by 288 · see citing works
Mechanisms and Mediators of the Skeletal Muscle Repeated Bout Effect
Hyldahl, R. D., Chen, T. C., & Nosaka, K. (2016) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000095 · Cited by 288 · see citing works
Humanin: a harbinger of mitochondrial-derived peptides
Lee, C., Yen, K., & Cohen, P. (2013) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2013.01.005 · Cited by 284 · see citing works
Ikonen, M., Liu, B., Hashimoto, Y., Ma, L., Lee, K., Niikura, T., Nishimoto, I., & Cohen, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135111100 · Cited by 279 · see citing works
Molecular mechanisms for mitochondrial adaptation to exercise training in skeletal muscle
Drake, J. C., Wilson, R. J., & Yan, Z. (2016) · The FASEB Journal · doi:10.1096/fj.15-276337 · Cited by 263 · see citing works
Humanin: A Novel Central Regulator of Peripheral Insulin Action
Muzumdar, R. H., Huffman, D. M., Atzmon, G., Buettner, C., Cobb, L. J., Fishman, S., Budagov, T., Cui, L., Einstein, F. H., Poduval, A., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006334 · Cited by 248 · see citing works
Mitocellular communication: Shaping health and disease
Mottis, A., Herzig, S., & Auwerx, J. H. (2019) · Science · doi:10.1126/science.aax3768 · Cited by 238 · see citing works
Mitochondrially derived peptides as novel regulators of metabolism
Kim, S., Xiao, J., Wan, J., Cohen, P., & Yen, K. (2017) · The Journal of Physiology · doi:10.1113/jp274472 · Cited by 184 · see citing works
Maximizing Cellular Adaptation to Endurance Exercise in Skeletal Muscle
Hawley, J. A., Lundby, C., Cotter, J. D., & Burke, L. M. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.04.014 · Cited by 182 · see citing works
Sreekumar, P. G., Ishikawa, K., Spee, C., Mehta, H. H., Wan, J., Yen, K., Cohen, P., Kannan, R., & Hinton, D. R. (2016) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.15-17053 · Cited by 179 · see citing works
Herst, P. M., & Berridge, M. V. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.11.018 · Cited by 171 · see citing works
Appleby, R. D., Porteous, W. K., Hughes, G., James, A. M., Shannon, D., Wei, Y., & Murphy, M. P. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00350.x · Cited by 164 · see citing works
Mitochondrial peptides modulate mitochondrial function during cellular senescence
Kim, S., Mehta, H. H., Wan, J., Kuehnemann, C., Chen, J., Hu, J., Hoffman, A. R., & Cohen, P. (2018) · Aging · doi:10.18632/aging.101463 · Cited by 135 · see citing works
Evidence for potential functionality of nuclearly-encoded humanin isoforms
Bodzioch, M., Lapicka-Bodzioch, K., Zapała, B., Kamysz, W., Kieć‐Wilk, B., & Dembinska-Kiec, A. (2009) · Genomics · doi:10.1016/j.ygeno.2009.05.006 · Cited by 123 · see citing works
Merry, T. L., Steinberg, G. R., Lynch, G. S., & McConell, G. K. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00239.2009 · Cited by 122 · see citing works
Self-citationCirculating humanin levels are associated with preserved coronary endothelial function
Widmer, R. J., Flammer, A. J., Herrmann, S. M., Rodriguez-Porcel, M. G., Wan, J., Cohen, P., Lerman, L. O., & Lerman, A. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00765.2012 · Cited by 117 · see citing works
Niikura, T., Hashimoto, Y., Tajima, H., Ishizaka, M., Yamagishi, Y., Kawasumi, M., Nawa, M., Terashita, K., Aiso, S., & Nishimoto, I. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02553.x · Cited by 115 · see citing works
Mitochondrial-Derived Peptides Are Down Regulated in Diabetes Subjects
Ramanjaneya, M., Bettahi, I., Jerobin, J., Chandra, P., Khalil, C. A., Skarulis, M. C., Atkin, S. L., & Abou‐Samra, A. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00331 · Cited by 110 · see citing works
Yen, K., Wan, J., Mehta, H. H., Miller, B., Christensen, A., Levine, M. E., Salomon, M. P., Brandhorst, S., Xiao, J., Kim, S., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-32616-7 · Cited by 97 · see citing works
Klein, L. E., Cui, L., Gong, Z., Su, K., & Muzumdar, R. H. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.08.055 · Cited by 95 · see citing works
Humanin is an endogenous activator of chaperone-mediated autophagy
Gong, Z., Tasset, I., Díaz, A., Anguiano, J., Tas, E., Cui, L., Kuliawat, R., Liu, H., Kühn, B., Cuervo, A. M., et al. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201606095 · Cited by 95 · see citing works
The role of ubiquitin–proteasome-dependent proteolysis in the remodelling of skeletal muscle
Taillandier, D., Combaret, L., Pouch-Pélissier, M.-N., Samuels, S., Béchet, D., & Attaix, D. (2004) · Proceedings of The Nutrition Society · doi:10.1079/par2004358 · Cited by 86 · see citing works
Kuliawat, R., Klein, L., Gong, Z., Nicoletta-Gentile, M., Nemkal, A., Cui, L., Bastie, C. C., Su, K., Huffman, D. M., Surana, M., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-231092 · Cited by 76 · see citing works
Gidlund, E., von Walden, F., Venojärvi, M., Risérus, U., Heinonen, O. J., Norrbom, J., & Sundberg, C. J. (2016) · Physiological Reports · doi:10.14814/phy2.13063 · Cited by 64 · see citing works
Pharmacokinetics and Tissue Distribution of Humanin and Its Analogues in Male Rodents
Chin, Y.-P., Keni, J., Wan, J., Mehta, H. H., Anene, F., Jia, Y., Lue, Y., Swerdloff, R. S., Cobb, L. J., Wang, C., et al. (2013) · Endocrinology · doi:10.1210/en.2012-2004 · Cited by 61 · see citing works
Hedges, C. P., Woodhead, J. S. T., Wang, H. W., Mitchell, C. J., Cameron‐Smith, D., Hickey, A. J., & Merry, T. L. (2018) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00777.2018 · Cited by 54 · see citing works
Mehta, H. H., Xiao, J., Ramírez, R., Miller, B., Kim, S., Cohen, P., & Yen, K. (2019) · Metabolomics · doi:10.1007/s11306-019-1549-7 · Cited by 46 · see citing works
Heo, J.-W., Yoo, S., No, M.-H., Park, D.-H., Kang, J.-H., Kim, T.-W., Kim, C.-J., Seo, D., Han, J., Yoon, J.-H., et al. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15102301 · Cited by 42 · see citing works
Morris, D. L., Kastner, D. W., Johnson, S., Strub, M., He, Y., Bleck, C. K. E., Lee, D., & Tjandra, N. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011297 · Cited by 38 · see citing works
Carré, J. L., Lamon, S., & Léger, B. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00413 · Cited by 34 · see citing works
Identification of human skeletal muscle miRNA related to strength by high-throughput sequencing
Mitchell, C. J., D’Souza, R. F., Schierding, W. S., Zeng, N., Ramzan, F., O'Sullivan, J. M., Poppitt, S. D., & Cameron‐Smith, D. (2018) · Physiological Genomics · doi:10.1152/physiolgenomics.00112.2017 · Cited by 34 · see citing works
Central effects of humanin on hepatic triglyceride secretion
Gong, Z., Su, K., Cui, L., Tas, E., Zhang, T., Dong, H. H., Yakar, S., & Muzumdar, R. H. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00043.2015 · Cited by 33 · see citing works
Ma, Y., Li, S., Wei, X., Huang, J., Lai, M., Wang, N., Huang, Q., Zhao, L., Peng, Y., & Wang, Y. (2018) · Gynecological Endocrinology · doi:10.1080/09513590.2018.1482869 · Cited by 12 · see citing works
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Merry, T. L., Chan, A., Woodhead, J. S. T., Reynolds, J. C., Kumagai, H., Kim, S.-J., & Lee, C. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00249.2020 · Cited by 141 · see citing works
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Burtscher, J., Soltany, A., Visavadiya, N. P., Burtscher, M., Millet, G. P., Khoramipour, K., & Khamoui, A. V. (2023) · Aging Cell · doi:10.1111/acel.13770 · Cited by 116 · see citing works
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Leuchtmann, A. B., Adak, V., Dilbaz, S., & Handschin, C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.709807 · Cited by 84 · see citing works
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Delgado‐Peraza, F., Nogueras‐Ortiz, C. J., Simonsen, A. H., Knight, D. D., Yao, P. J., Goetzl, E. J., Jensen, C. S., Høgh, P., Gottrup, H., Vestergaard, K., et al. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01303-9 · Cited by 74 · see citing works
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Kim, S., Miller, B., Kumagai, H., Silverstein, A. R., Flores, M., & Yen, K. (2020) · GeroScience · doi:10.1007/s11357-020-00262-5 · Cited by 73 · see citing works
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Zanini, G., De Gaetano, A., Selleri, V., Savino, G., Cossarizza, A., Pinti, M., Mattioli, A. V., & Nasi, M. (2021) · Cells · doi:10.3390/cells10102575 · Cited by 46 · see citing works
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Li, Y., Li, Z., Ren, Y., Lei, Y., Yang, S., Shi, Y., Peng, H., Yang, W., Guo, T., Yu, Y., et al. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.11.018 · Cited by 43 · see citing works
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Self-citationMitochondrial-derived vesicles in skeletal muscle remodeling and adaptation
Picca, A., Guerra, F., Calvani, R., Romanò, R., Coelho‐Júnior, H. J., Bucci, C., Leeuwenburgh, C., & Marzetti, E. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.03.023 · Cited by 28 · see citing works
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Xiao, J., Zhang, Q., Shan, Y., Ye, F., Zhang, X., Cheng, J. S., Wang, X., Zhao, Y., Dan, G., Chen, M., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03443-3 · Cited by 19 · see citing works
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“Age may also influence responses; some studies suggest that older adults show blunted irisin responses to training compared with younger populations [40,77].”
Lang, A., Oehler, D., Benkhoff, M., Reinders, Y., Barcik, M., Shahrjerdi, K., Kaldirim, M., Sickmann, A., Dannenberg, L., Polzin, A., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12102368 · Cited by 3 · see citing works
Chitkara, M. (2023) · SN Computer Science · doi:10.1007/s42979-023-02234-w · Cited by 3 · see citing works
Peng, M., Zhou, Y., Wang, Y., Yi, Z., Li, S., & Wan, C. (2023) · Journal of Proteome Research · doi:10.1021/acs.jproteome.3c00608 · Cited by 3 · see citing works
Mitochondrial Function and Dysfunction in White Adipocytes and Therapeutic Implications
Wang, F., Huynh, P. M., & An, Y. (2024) · Comprehensive physiology · doi:10.1002/cphy.c230009 · Cited by 9 · see citing works
Kutuk, I. S., Akın, Ş., Demirel, H. A., Mümüşoğlu, S., Çiftçi, T., & Yıldız, B. O. (2025) · Journal of Endocrinological Investigation · doi:10.1007/s40618-025-02747-6 · Cited by 1 · see citing works
Emerging Therapeutic Potential of Short Mitochondrial-produced Peptides for Anabolic Osteogenesis
Noreldin, A. E., Saadeldin, I. M., Khalifa, N. E., & Khafaga, A. F. (2022) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-021-10353-2 · Cited by 1 · see citing works
Yousef, H., Jelinek, H. F., Feng, S. F., Khandoker, A. H., & Tarvainen, M. P. (2022) · Computing in cardiology · doi:10.22489/cinc.2022.223
Humanin activates integrin αV-TGFβ axis and leads to glioblastoma progressionPreprint
Jeong, Y., Hua, T. N. M., Vo, V. T. A., Om, J.-Y., Han, S., Cha, S., Park, K., & Ha, C. P. (2023) · Research Square · doi:10.21203/rs.3.rs-2702693/v1
Exercise and Energy Metabolism in Cancer Research
Vulczak, A., & Alberici, L. C. (2024) · Interdisciplinary cancer research · doi:10.1007/16833_2024_228
Askarimoghadam, H., Rostamzadeh, F., Goki, M. M., Jafari, E., & Yeganeh‐Hajahmadi, M. (2025) · Journal of Aging Research · doi:10.1155/jare/9949234 · Cited by 1 · see citing works
Delgado‐Peraza, F., Nogueras‐Ortiz, C. J., Simonsen, A. H., Knight, D. D., Yao, P. J., Goetzl, E. J., Jensen, C. S., Høgh, P., Gottrup, H., Vestergaard, K., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24172219
Liao, Y., Xu, J., Jiao, Y., Sun, X., Gao, M., Ding, Y., Cai, D., Shen, Y., Zhou, X., & Han, W. (2026) · Biomedicines · doi:10.3390/biomedicines14051048
Horwath, O., Corell, L., Wan, J., Hjalmarsson, E., Starck, J., Reitzner, S. M., Norrbom, J., Fernandez‐Gonzalo, R., Kvist, O., Cohen, P., et al. (2026) · Experimental Physiology · doi:10.1113/ep093298
A peripheral perspective on brain health: vascular and skeletal muscle contributions
Keller, J. L., Pennartz, K. J., Sprick, J. D., Hein, E. J., Irving, B. A., Vann, C. G., Butlig, E.-A. R., Al-Masri, S., & Nelson, A. R. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00462.2026
Ayubi, N., Wibawa, J. C., Kurnaz, M., & Komaini, A. (2026) · Physiology International · doi:10.1556/2060.2026.00863
- Authors
- Woodhead, J. S. T., D’Souza, R. F., Hedges, C. P., Wan, J., Berridge, M. V., Cameron-Smith, D., Cohen, P., Hickey, A. J. R., Mitchell, C. J., & Merry, T. L.
- Affiliations
- University of Auckland (NZ)
- University of Southern California (US)
- Malaghan Institute of Medical Research (NZ)
- Liggins Institute, The University of Auckland, Auckland, New Zealand
- University of British Columbia (CA)
- Corresponding author
- Merry, Troy L.
- ORCID
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2020-05-01
- Volume
- 128
- Issue
- 5
- Pages
- 1346-1354
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- PMC
- PMC7717117
- OpenAlex
- W3015282965
- Cited by
- 57
- References
- 43
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 12 · 2023: 15 · 2022: 9 · 2021: 9 · 2020: 2
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Royal Society of New Zealand | Marsden Fund (16-UOA-313)
- Rutherford Discovery Fellowship (RDF-15-UOA-020)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- humanin, mitochondrial peptides, high-intensity interval exercise, exercise adaptation, plasma peptides, skeletal muscle, mitochondrial genome, cytoprotection
- MeSH terms
- High-Intensity Interval Training, Adult, Animals, Humans, Male, Peptides, Muscle, Skeletal, Genes, rRNA, Intracellular Signaling Peptides and Proteins, Mice, Young Adult
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