A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease‐relevant insults

Mechanisms Underlying Ubiquitination

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Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

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The tripartite motif family identifies cell compartments

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RING Finger Proteins

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RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

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The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase

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Impaired Proteasome Function in Alzheimer's Disease

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Does this have a familiar RING?

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A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ

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UBIQUITIN AND THE CONTROL OF PROTEIN FATE IN THE SECRETORY AND ENDOCYTIC PATHWAYS

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TRIM family proteins and their emerging roles in innate immunity

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TRIM/RBCC, a novel class of ‘single protein RING finger’ E3 ubiquitin ligases

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Targeting Proteins for Destruction by the Ubiquitin System: Implications for Human Pathobiology

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Species-Specific Variation in the B30.2(SPRY) Domain of TRIM5α Determines the Potency of Human Immunodeficiency Virus Restriction

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Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues

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Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis

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TRIM E3 Ligases Interfere with Early and Late Stages of the Retroviral Life Cycle

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Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk–lipid droplets

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The emerging role of the mitochondrial-derived peptide humanin in stress resistance

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Trim32 is a Ubiquitin Ligase Mutated in Limb Girdle Muscular Dystrophy Type 2H that Binds to Skeletal Muscle Myosin and Ubiquitinates Actin

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Structural and functional insights into the B30.2/SPRY domain

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Characterization of Endogenous Human Promyelocytic Leukemia Isoforms

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Mitochondrial stress signaling in longevity: A new role for mitochondrial function in aging

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A Specific Region of 37 Amino Acid Residues in the SPRY (B30.2) Domain of African Green Monkey TRIM5α Determines Species-Specific Restriction of Simian Immunodeficiency Virus SIVmac Infection

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Evidence for potential functionality of nuclearly-encoded humanin isoforms

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Intracellular Origin of Milk Fat Globules and the Nature of the Milk Fat Globule Membrane

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Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin–proteosome systemPreprint

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Functional interactions between ubiquitin E2 enzymes and TRIM proteins

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APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer’s disease

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Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer’s disease-relevant insults

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Humanin and Age-Related Diseases: A New Link?

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Trim Proteins as Ring Finger E3 Ubiquitin Ligases

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Protective Mechanism of Humanin Against Oxidative Stress in Aging-Related Cardiovascular Diseases

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TRIM37 defective in mulibrey nanism is a novel RING finger ubiquitin E3 ligase

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Contribution of E3-Ubiquitin Ligase Activity to HIV-1 Restriction by TRIM5α rh : Structure of the RING Domain of TRIM5α

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Cutaneous Melanocytoma With CRTC1-TRIM11 Fusion

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The Ubiquitin System in Alzheimer’s Disease

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Unravelling the role of Humanin

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Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease‐related neurotoxicity: functional potentiation by isomerization and dimerization

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Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer’s disease

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TRIM11, a direct target of miR-24-3p, promotes cell proliferation and inhibits apoptosis in colon cancer

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Modulation of Retroviral Restriction and Proteasome Inhibitor-Resistant Turnover by Changes in the TRIM5α B-Box 2 Domain

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TRIM11 is overexpressed in high-grade gliomas and promotes proliferation, invasion, migration and glial tumor growth

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Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties

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Biochemical and Biophysical Characterization of a Chimeric TRIM21-TRIM5α Protein

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TRIM32 Protein Sensitizes Cells to Tumor Necrosis Factor (TNFα)-induced Apoptosis via Its RING Domain-dependent E3 Ligase Activity against X-linked Inhibitor of Apoptosis (XIAP)

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A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation

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The Role of Ubiquitin-Protein Ligases in Neurodegenerative Disease

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TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process

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High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men

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Distinct Expression of Long Non-Coding RNAs in an Alzheimer's Disease Model

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Tumor suppressor p53 cross-talks with TRIM family proteins

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Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology

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TRIM11 Negatively Regulates IFNβ Production and Antiviral Activity by Targeting TBK1

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Humanin: After the Discovery

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Mitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases

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Environmental monitoring of Domingo Rubio stream (Huelva Estuary, SW Spain) by combining conventional biomarkers and proteomic analysis in Carcinus maenas

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Tripartite motif-containing 3 (TRIM3) inhibits tumor growth and metastasis of liver cancer

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The Molecular Structure and Role of Humanin in Neural and Skeletal Diseases, and in Tissue Regeneration

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Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer

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Emerging Roles of Tripartite Motif-Containing Family Proteins (TRIMs) in Eliminating Misfolded Proteins

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Humanin: Functional Interfaces with IGF-I

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Proliferation and invasion of ovarian cancer cells are suppressed by knockdown of TRIM11

Chen, Y., Sun, J., & Ma, J. (2017) · Oncology Letters · doi:10.3892/ol.2017.6432 · Cited by 40

Upregulated TRIM11 Exerts its Oncogenic Effects in Hepatocellular Carcinoma Through Inhibition of P53

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VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin

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Roles of the ubiquitin-proteosome system in neurogenesis

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Common disease signatures from gene expression analysis in Huntington’s disease human blood and brain

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Strategies for the identification of ubiquitin ligase inhibitors

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Role of TRIM5α RING Domain E3 Ubiquitin Ligase Activity in Capsid Disassembly, Reverse Transcription Blockade, and Restriction of Simian Immunodeficiency Virus

Kim, J., Tipper, C. H., & Sodroski, J. (2011) · Journal of Virology · doi:10.1128/jvi.00341-11 · Cited by 35

High expression of TRIM11 correlates with poor prognosis in patients with hepatocellular carcinoma

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Humanin and Alzheimer's disease: The beginning of a new field

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TRIM11 binds to and destabilizes a key component of the activator‐mediated cofactor complex (ARC105) through the ubiquitin–proteasome system

Ishikawa, H., Tachikawa, H., Miura, Y., & Takahashi, N. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.07.066 · Cited by 32

Protective Effects of Humanin and Calmodulin-Like Skin Protein in Alzheimer’s Disease and Broad Range of Abnormalities

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Expression of Tripartite Motif-Containing Proteactiin 11 (TRIM11) is Associated with the Progression of Human Prostate Cancer and is Downregulated by MicroRNA-5193

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Loss of the novel tumour suppressor and polarity gene Trim62 ( Dear1 ) synergizes with oncogenic Ras in invasive lung cancer

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation in vitro and in vivo

Wang, L., Wu, J., Yuan, J. X., Zhu, X., Wu, H., & Li, M. (2016) · Frontiers of Medicine · doi:10.1007/s11684-016-0429-z · Cited by 27

Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c)

Yoon, T. K., Lee, C. H., Kwon, O., & Kim, M. (2022) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2022.0092 · Cited by 28

Neuroprotection against neurodegenerative diseases

Chiba, T., Nishimoto, I., Aiso, S., & Matsuoka, M. (2007) · Molecular Neurobiology · doi:10.1007/bf02700624 · Cited by 27

Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors

Gottardo, M. F., Pidre, M. L., Zuccato, C. F., Asad, A. S., Imsen, M., Jaita, G., Candolfi, M., Romanowski, V., & Seilicovich, A. (2018) · APOPTOSIS · doi:10.1007/s10495-018-1444-0 · Cited by 26

Mitochondrial-derived peptides and exercise

Woodhead, J. S. T., & Merry, T. L. (2021) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2021.130011 · Cited by 27

Tripartite motif‐containing protein 11 promotes hepatocellular carcinogenesis through ubiquitin‐proteasome–mediated degradation of pleckstrin homology domain leucine‐rich repeats protein phosphatase 1

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Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer’s disease models via the heterotrimeric Humanin receptor

Hashimoto, Y., Nawa, M., Kurita, M., Tokizawa, M., Iwamatsu, A., & Matsuoka, M. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.80 · Cited by 25

Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin

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The E3 ubiquitin ligase TRIM11 mediates the degradation of congenital central hypoventilation syndrome-associated polyalanine-expanded PHOX2B

Parodi, S., Zanni, E. D., Lascio, S. D., Bocca, P., Prigione, I., Fornasari, D., Pennuto, M., Bachetti, T., & Ceccherini, I. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0868-1 · Cited by 22

Trim11 increases expression of dopamine β-hydroxylase gene by interacting with Phox2b

Hong, S. J., Chae, H., Lardaro, T., Hong, S., & Kim, K. S. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.01.165 · Cited by 22

A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11

Cooper, S. T., & Hanson, I. M. (2005) · BMC Genetics · doi:10.1186/1471-2156-6-43 · Cited by 21

Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer’s disease

Benaki, D. C., Zikos, C. C., Evangelou, A., Livaniou, E., Vlassi, M., Mikros, E., & Pelecanou, M. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.08.087 · Cited by 21

Many Faces of TRIM Proteins on the Road from Pluripotency to Neurogenesis

Nenasheva, V. V., & Tarantul, V. Z. (2019) · Stem Cells and Development · doi:10.1089/scd.2019.0152 · Cited by 20

TRIM66 expression in non-small cell lung cancer: A new predictor of prognosis

Ma, Y., Dai, H., Zhang, F., & Zhao, D. (2017) · Cancer Biomarkers · doi:10.3233/cbm-170207 · Cited by 17

SUMOylation of MCL1 protein enhances its stability by regulating the ubiquitin-proteasome pathway

Li, S., Wang, J., Hu, G., Aman, S., Li, B., Li, Y., Xia, K., Yang, Y., Ahmad, B., Wang, M., et al. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109686 · Cited by 17

FBXL21 association with schizophrenia in irish family and case–control samples

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Mitochondrial-derived peptides: Antidiabetic functions and evolutionary perspectives

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The Human Antiviral Factor TRIM11 Is under the Regulation of HIV-1 Vpr

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Humanin Structural Versatility and Interaction with Model Cerebral Cortex Membranes

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Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide

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Tripartite Motif Containing 11 Interacts with DUSP6 to Promote the Growth of Human Osteosarcoma Cells through Regulating ERK1/2 Pathway

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Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis

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Therapeutic, diagnostic and prognostic values of TRIM proteins in prostate cancer

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Bioinformatics gene analysis for potential biomarkers and therapeutic targets of Parkinson’s disease based on neutrophil extracellular traps

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Sequence Variant in the TRIM39-RPP21 Gene Readthrough is Shared Across a Cohort of Arabian Foals Diagnosed with Juvenile Idiopathic Epilepsy.

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SUMO1 modification of 0N4R-tau is regulated by PIASx, SENP1, SENP2, and TRIM11

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Gene fusion–driven cutaneous mesenchymal neoplasms: An updated review emphasizing the emerging entities

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Structure of three Humanin peptides with different activities upon interaction with liposome

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Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system

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Structure changes of natively disordered Humanin in the presence of lipid

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Humanin: a potential peptide for neuroprotective therapy against Alzheimer's disease

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Humanin and Alzheimer's disease: The beginning of a new field

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Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer’s disease-relevant insults

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A Humanin Derivative Reduces Amyloid Beta Accumulation and Ameliorates Memory Deficit in Triple Transgenic Mice

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