The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The ablation of glial fibrillary acidic protein‐positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells
Abstract
The adult mammalian forebrain subependyma contains neural stem cells (NSCs) capable of self‐renewal and multilineage differentiation. The in vivo identification of NSCs has not been definitively addressed using a loss of function approach. Using a transgenic mouse expressing herpes‐simplex virus thymidine kinase from the glial fibrillary acidic protein (GFAP) promotor, we have selectively killed dividing GFAP‐positive cells in the presence of ganciclovir (GCV) and shown a > 95% loss in the numbers of NSCs, as assayed by the formation of clonally derived neurospheres in vitro. This loss is seen following 3 days of GCV exposure in vivo or in vitro only and cannot be rescued by coculturing with pure astrocyte populations or control (green fluorescent protein‐expressing) subependymal cells. Exposure to GCV in vitro has no effect on adult retinal stem cells hence, we conclude that adult forebrain NSCs comprise a subpopulation of the GFAP‐positive cells within the subependyma.
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Cites
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
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Self-citationIsolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage
Malatesta, P., Hartfuss, E., & Götz, M. (2000) · Development · doi:10.1242/dev.127.24.5253 · Cited by 1,157
Pekny, M., Levéen, P., Pekna, M., Eliasson, C., Berthold, C. H., Westermark, B., & Betsholtz, C. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07147.x · Cited by 336
Cited by
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475
Garcia, A. D. R., Doan, N. B., Imura, T., Bush, T. G., & Sofroniew, M. V. (2004) · Nature Neuroscience · doi:10.1038/nn1340 · Cited by 990
Self-citationAdult neurogenesis: from precursors to network and physiology
Abrous, D. N., Koehl, M., & Le Moal, M. (2005) · Physiological Reviews · doi:10.1152/physrev.00055.2003 · Cited by 971
The glial identity of neural stem cells
Doetsch, F. (2003) · Nature Neuroscience · doi:10.1038/nn1144 · Cited by 724
Codega, P., Silva-Vargas, V., Paul, A., Maldonado-Soto, A. R., DeLeo, A. M., Pastrana, E., & Doetsch, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.039 · Cited by 634
Metadata
- Authors
- Morshead, C. M., Garcia, A. D., Sofroniew, M. V., & Van Der Kooy, D.
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2003-07
- Volume
- 18
- Issue
- 1
- Pages
- 76-84
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W1967876791
- Cited by
- 223
- References
- 4
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Morshead, C. M., Garcia, A. D., Sofroniew, M. V., & Van Der Kooy, D. (2003). The ablation of glial fibrillary acidic protein‐positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells. European Journal of Neuroscience. https://doi.org/10.1046/j.1460-9568.2003.02727.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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