Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996) · Nature · doi:10.1038/379606a0 · Cited by 2,476 · see citing works

Chemical Neuroanatomy

Emson, P. C., Heffher, R. R., & Pearson, J. M. (1984) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198409000-00010 · Cited by 1,650 · see citing works

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

Hirsch, E., Graybiel, A. M., & Agid, Y. A. (1988) · Nature · doi:10.1038/334345a0 · Cited by 1,301 · see citing works

A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes

Schaeren‐Wiemers, N., & Gerfin-Moser, A. (1993) · Histochemistry and Cell Biology · doi:10.1007/bf00267823 · Cited by 1,162 · see citing works

Dopamine Neuron Agenesis in Nurr1-Deficient Mice

Zetterström, R. H., Solomin, L., Jansson, L., Hoffer, B. J., Olson, L., & Perlmann, T. (1997) · Science · doi:10.1126/science.276.5310.248 · Cited by 1,096 · see citing works

Handbook of chemical neuroanatomy

(2005) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(05)80001-6 · Cited by 906 · see citing works

FGF and Shh Signals Control Dopaminergic and Serotonergic Cell Fate in the Anterior Neural Plate

Ye, W., Shimamura, K., Rubenstein, J. L. R., Hynes, M., & Rosenthal, A. (1998) · Cell · doi:10.1016/s0092-8674(00)81437-3 · Cited by 878 · see citing works

Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons

Cárdenas, O. S., Quintana-Hau, J. D. D., Le, W., Smidt, M. P., Cox, J. J., Mayo, F. J. D., Burbach, J. P. H., & Conneely, O. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.4013 · Cited by 744 · see citing works

Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic

Zhou, Q.-Y., & Palmiter, R. D. (1995) · Cell · doi:10.1016/0092-8674(95)90145-0 · Cited by 731 · see citing works

Identification of the DNA Binding Site for NGFI-B by Genetic Selection in Yeast

Wilson, T. E., Fahrner, T. J., Johnston, M., & Milbrandt, J. (1991) · Science · doi:10.1126/science.1925541 · Cited by 557 · see citing works

Complete coding sequence of rat tyrosine hydroxylase mRNA.

Grima, B., Lamouroux, A., Blanot, F., Biguet, N. F., & Mallet, J. J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.2.617 · Cited by 534 · see citing works

Multiple developmental defects in Engrailed - 1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum

Wurst, W., Auerbach, A. B., & Joyner, A. L. (1994) · Development · doi:10.1242/dev.120.7.2065 · Cited by 516 · see citing works

Induction of midbrain dopaminergic neurons by Sonic hedgehog

Hynes, M., Porter, J. A., Chiang, C. C., Chang, D. T., Tessier‐Lavigne, M., Beachy, P. A., & Rosenthal, A. (1995) · Neuron · doi:10.1016/0896-6273(95)90062-4 · Cited by 481 · see citing works

VMAT2 knockout mice: Heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity

Takahashi, N., Miner, L. L., Sora, I., Ujike, H., Revay, R. S., Kostić, V., Jackson-Lewis, V. R., Przedborski, S., & Uhl, G. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9938 · Cited by 429 · see citing works

Rescue of the En-1 Mutant Phenotype by Replacement of En-1 with En-2

Hanks, M. C., Wurst, W., Anson‐Cartwright, L., Auerbach, A. B., & Joyner, A. L. (1995) · Science · doi:10.1126/science.7624797 · Cited by 398 · see citing works

A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b

Smidt, M. P., Asbreuk, C. H. J., Cox, J. J., Chen, H., Johnson, R. L., & Burbach, J. P. H. (2000) · Nature Neuroscience · doi:10.1038/73902 · Cited by 394 · see citing works

The mouse Pax2 1Neu mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney

Favor, J., Sandulache, R., Neuhäuser-Klaus, A., Pretsch, W., Chatterjee, B., Senft, E., Wurst, W., Blanquet, V., Grimes, P. A., Spörle, R., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13870 · Cited by 391 · see citing works

A homeodomain gene Ptx 3 has highly restricted brain expression in mesencephalic dopaminergic neurons

Smidt, M. P., van Schaick, H. S. A., Lanctôt, C., Tremblay, J., Cox, J. J., van der Kleij, A. A. M., Wolterink, G., Drouin, J., & Burbach, J. P. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13305 · Cited by 363 · see citing works

Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain

Sakurada, K., Ohshima-Sakurada, M., Palmer, T. D., & Gage, F. H. (1999) · Development · doi:10.1242/dev.126.18.4017 · Cited by 359 · see citing works

Cellular expression of the immediate early transcription factors Nurr1 and NGFI-B suggests a gene regulatory role in several brain regions including the nigrostriatal dopamine system

Zetterström, R. H., Williams, R., Perlmann, T., & Olson, L. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00074-5 · Cited by 340 · see citing works

Vesicular Transport Regulates Monoamine Storage and Release but Is Not Essential for Amphetamine Action

Fon, E. A., Pothos, E. N., Sun, B.-C., Killeen, N. P., Sulzer, D. L., & Edwards, R. H. (1997) · Neuron · doi:10.1016/s0896-6273(00)80418-3 · Cited by 337 · see citing works

Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system

Hirsch, M., Tiveron, M.-C., Guillemot, F., Brunet, J., & Goridis, C. (1998) · Development · doi:10.1242/dev.125.4.599 · Cited by 327 · see citing works

Dopamine Biosynthesis Is Selectively Abolished in Substantia Nigra/Ventral Tegmental Area but Not in Hypothalamic Neurons in Mice with Targeted Disruption of the Nurr1 Gene

Castillo, S. O., Baffi, J., Palkovits, M., Goldstein, D. S., Kopin, I. J., Witta, J., Magnuson, M. A., & Nikodem, V. M. (1998) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1998.0673 · Cited by 292 · see citing works

Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development

Danielian, P. S., & McMahon, A. P. (1996) · Nature · doi:10.1038/383332a0 · Cited by 290 · see citing works

Re-evaluation of the role of the dopamine transporter in dopamine system homeostasis1Published on the World Wide Web on 27 January 1998.1

Gainetdinov, R. R., Jones, S. R., Fumagalli, F., Wightman, R. M., & Caron, M. G. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00063-5 · Cited by 263 · see citing works

Loss of autoreceptor functions in mice lacking the dopamine transporter

Jones, S. R., Gainetdinov, R. R., Hu, X., Cooper, D., Wightman, R. M., White, F. J., & Caron, M. G. (1999) · Nature Neuroscience · doi:10.1038/10204 · Cited by 247 · see citing works

Specification of dopaminergic and serotonergic neurons in the vertebrate CNS

Hynes, M., & Rosenthal, A. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80004-x · Cited by 228 · see citing works

Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism

Sacchetti, P., Mitchell, T. R., Granneman, J. G., & Bannon, M. J. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00181.x · Cited by 209 · see citing works

Sequential roles for Fgf4, En1 and Fgf8 in specification and regionalisation of the midbrain

Shamim, H., Mahmood, R., Logan, C., Doherty, P., Lumsden, A., & Mason, I. J. (1999) · Development · doi:10.1242/dev.126.5.945 · Cited by 199 · see citing works

Reduced Nurrl Expression Increases the Vulnerability of Mesencephalic Dopamine Neurons to MPTP‐Induced Injury

Le, W. D., Conneely, O. M., He, Y., Jankovic, J. J., & Appel, S. H. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.02218.x · Cited by 187 · see citing works

Increased MPTP Neurotoxicity in Vesicular Monoamine Transporter 2 Heterozygote Knockout Mice

Gainetdinov, R. R., Fumagalli, F., Wang, Y., Jones, S. R., Levey, A. I., Miller, G. W., & Caron, M. G. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70051973.x · Cited by 178 · see citing works

Specification of Neurotransmitter Identity by Phox2 Proteins in Neural Crest Stem Cells

Lo, L., Morin, X., Brunet, J., & Anderson, D. J. (1999) · Neuron · doi:10.1016/s0896-6273(00)80729-1 · Cited by 172 · see citing works

Cooperation of Pax2 and Pax5 in midbrain and cerebellum development

Urbánek, P., Fetka, I., Meisler, M. H., & Busslinger, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5703 · Cited by 162 · see citing works

Orphan Nuclear Receptor Nurr1 Is Essential for Ret Expression in Midbrain Dopamine Neurons and in the Brain Stem

Wallén‐Mackenzie, Å., Castro, D. S., Zetterström, R. H., Karlén, M., Olson, L., Ericson, J., & Perlmann, T. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.1057 · Cited by 149 · see citing works

Dopamine-Deficient Mice Are Hypersensitive to Dopamine Receptor Agonists

Kim, D. S., Szczypka, M. S., & Palmiter, R. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04405.2000 · Cited by 144 · see citing works

Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter

Jaber, M., Dumartin, B., Sagné, C., Haycock, J. W., Roubert, C., Bruno Giros, A., Bloch, B., & Caron, M. G. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00764.x · Cited by 143 · see citing works

Characterization of the 5′-flanking region of the human dopamine transporter gene

Sacchetti, P., Brownschidle, L. A., Granneman, J. G., & Bannon, M. J. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00275-2 · Cited by 135 · see citing works

A selective group of dopaminergic neurons express Nurr1 in the adult mouse brain

Bäckman, C. M., Perlmann, T., Wallén‐Mackenzie, Å., Hoffer, B. J., & Morales, M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02149-6 · Cited by 117 · see citing works

Distribution of messenger RNAs for the orphan nuclear receptors Nurr1 and Nur77 (NGFI-B) in adult rat brain using in situ hybridization

Xiao, Q., Castillo, S. O., & Nikodem, V. M. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00159-5 · Cited by 114 · see citing works

Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers

Bannon, M. J., Pruetz, B., Manning-Bog, A., Whitty, C. J., Michelhaugh, S. K., Sacchetti, P., Granneman, J. G., Mash, D. C., & Schmidt, C. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092654299 · Cited by 109 · see citing works

Comparative distribution of NURR1 and NUR77 nuclear receptors in the mouse central nervous system

Cárdenas, O. S., & Conneely, O. M. (1996) · Journal of Molecular Neuroscience · doi:10.1007/bf02736848 · Cited by 106 · see citing works

A homeodomain protein selectively expressed in noradrenergic tissue regulates transcription of neurotransmitter biosynthetic genes

Zellmer, E., Zhang, Z., Greco, D., Rhodes, J., Cassel, S. H., & Lewis, E. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-12-08109.1995 · Cited by 104 · see citing works

4.5 kb of the rat tyrosine hydroxylase 5′ flanking sequence directs tissue specific expression during development and contains consensus sites for multiple transcription factors

Schimmel, J. J., Crews, L., Roffler-Tarlov, S. K., & Chikaraishi, D. M. (1999) · Molecular Brain Research · doi:10.1016/s0169-328x(99)00234-x · Cited by 76 · see citing works

The Homeodomain Protein Arix Interacts Synergistically with Cyclic AMP to Regulate Expression of Neurotransmitter Biosynthetic Genes

Swanson, D. J., Zellmer, E., & Lewis, E. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.43.27382 · Cited by 75 · see citing works

Differential regulation of transcription by the NURR1/NUR77 subfamily of nuclear transcription factors.

Murphy, E. P., Dobson, A. D. W., Keller, C., & Conneely, O. M. (1996) · Europe PMC (PubMed Central) · Cited by 66 · see citing works

Prenatal ontogeny of tyrosine hydroxylase gene expression in the rat ventral mesencephalon

Solberg, Y., Silverman, W. F., & Pollack, Y. (1993) · Developmental Brain Research · doi:10.1016/0165-3806(93)90050-k · Cited by 29 · see citing works

The Biochemical Basis of Neuropharmacology

Check, W. A. (1978) · JAMA · doi:10.1001/jama.1978.03290070087031 · Cited by 7 · see citing works

The NR4A Subgroup: Immediate Early Response Genes with Pleiotropic Physiological Roles

Maxwell, M., & Muscat, G. E. O. (2006) · Nuclear Receptor Signaling · doi:10.1621/nrs.04002 · Cited by 447 · see citing works

How to make a mesodiencephalic dopaminergic neuron

Smidt, M. P., & Burbach, J. P. H. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2039 · Cited by 356 · see citing works

The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease

Jankovic, J., Chen, S., & Le, W. D. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.09.001 · Cited by 325 · see citing works

Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain genePitx3

Smidt, M. P., Smits, S. M., Bouwmeester, H., Hamers, F. P. T., van der Linden, A. J. A., Hellemons, A. J. C. G. M., Graw, J., & Burbach, J. P. H. (2004) · Development · doi:10.1242/dev.01022 · Cited by 317 · see citing works

How to make a midbrain dopaminergic neuron

Arenas, E., Denham, M., & Villaescusa, C. (2015) · Development · doi:10.1242/dev.097394 · Cited by 306 · see citing works

A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo

Prakash, N., Brodski, C., Naserke, T., Puelles, E., Gogoi, R., Hall, A. C., Panhuysen, M., Echevarrı́a, D., Sussel, L., Weisenhorn, D. M. V., et al. (2005) · Development · doi:10.1242/dev.02181 · Cited by 254 · see citing works

The Evolution of Dopamine Systems in Chordates

Yamamoto, K., & Vernier, P. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00021 · Cited by 241 · see citing works

NURR1 in Parkinson disease—from pathogenesis to therapeutic potential

Decressac, M., Volakakis, N., Björklund, A., & Perlmann, T. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.209 · Cited by 234 · see citing works

Age‐specific progression of nigrostriatal dysfunction in Parkinson's disease

de la Fuente‐Fernández, R., Schulzer, M., Kuramoto, L., Cragg, J., Ramachandiran, N., Au, W. L., Mak, E., McKenzie, J., McCormick, S., Sossi, V., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22284 · Cited by 222 · see citing works

Developmental exposure to the pesticide dieldrin alters the dopamine system and increases neurotoxicity in an animal model of Parkinson's disease

Richardson, J. R., Caudle, W. M., Wang, M., Dean, E. D., Pennell, K. D., & Miller, G. W. (2006) · The FASEB Journal · doi:10.1096/fj.06-5864fje · Cited by 215 · see citing works

Development of dopaminergic neurons in the mammalian brain

Prakash, N., & Wurst, W. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5387-6 · Cited by 207 · see citing works

The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis

Oades, R. D., Lasky-Su, J., Christiansen, H., Faraone, S. V., Sonuga-Barke, E. J. S., Banaschewski, T., Chen, W., Anney, R. J. L., Buitelaar, J. K., Ebstein, R. P., et al. (2008) · Behavioral and Brain Functions · doi:10.1186/1744-9081-4-48 · Cited by 200 · see citing works

Midbrain dopaminergic neurons: A review of the molecular circuitry that regulates their development

Hegarty, S. V., Sullivan, A. M., & O’Keeffe, G. W. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.04.014 · Cited by 190 · see citing works

Transcriptional control of midbrain dopaminergic neuron development

Ang, S. (2006) · Development · doi:10.1242/dev.02501 · Cited by 175 · see citing works

Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression

Jacobs, F. M. J., van Erp, S., van der Linden, A. J. A., von Oerthel, L., Burbach, J. P. H., & Smidt, M. P. (2009) · Development · doi:10.1242/dev.029769 · Cited by 159 · see citing works

Age-dependent dopaminergic dysfunction in Nurr1 knockout mice

Jiang, C., Wan, X., He, Y., Pan, T., Jankovic, J. J., & Le, W. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.08.035 · Cited by 154 · see citing works

Nurr1, an orphan nuclear receptor with essential functions in developing dopamine cells

Perlmann, T., & Wallén‐Mackenzie, Å. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0974-7 · Cited by 149 · see citing works

Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency

Jacobs, F. M. J., Smits, S. M., Noorlander, C. W., von Oerthel, L., van der Linden, A. J. A., Burbach, J. P. H., & Smidt, M. P. (2007) · Development · doi:10.1242/dev.02865 · Cited by 141 · see citing works

Emerging restorative treatments for Parkinson's disease

Deierborg, T., Soulet, D., Roybon, L., Hall, V. J., & Brundin, P. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.05.001 · Cited by 139 · see citing works

Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine

Ferreira, R., Napoli, J., Enver, T., Bernardino, L., & Ferreira, L. (2020) · Nature Communications · doi:10.1038/s41467-020-18042-2 · Cited by 138 · see citing works

Preliminary evidence for a modulation of fetal dopaminergic development by maternal immune activation during pregnancy

Meyer, U., Engler, A., Weber, L., Schedlowski, M., & Feldon, J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.031 · Cited by 135 · see citing works

Development and function of the midbrain dopamine system: what we know and what we need to

Bissonette, G. B., & Roesch, M. R. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12257 · Cited by 133 · see citing works

Developmental origin and fate of meso-diencephalic dopamine neurons

Smits, S. M., Burbach, J. P. H., & Smidt, M. P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.12.003 · Cited by 123 · see citing works

Vitamin C Facilitates Dopamine Neuron Differentiation in Fetal Midbrain Through TET1- and JMJD3-Dependent Epigenetic Control Manner

He, X., Kim, M., Kim, S., Yi, S., Rhee, Y., Kim, T., Lee, E.-H., Park, C., Dixit, S., Harrison, F. E., et al. (2014) · Stem Cells · doi:10.1002/stem.1932 · Cited by 119 · see citing works

The transcription factor PITX3 is associated with sporadic Parkinson's disease

Fuchs, J., Mueller, J. C., Lichtner, P., Schulte, C., Munz, M., Berg, D., Wüllner, U., Illig, T., Sharma, M., & Gasser, T. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.08.014 · Cited by 115 · see citing works

Homeobox gene Pitx3 and its role in the development of dopamine neurons of the substantia nigra

Smidt, M. P., Smits, S. M., & Burbach, J. P. H. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0943-1 · Cited by 114 · see citing works

Differential expression of dopaminergic cell markers in the adult zebrafish forebrain

Yamamoto, K., Ruuskanen, J. O., Wullimann, M. F., & Vernier, P. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22535 · Cited by 113 · see citing works

Prenatal exposure to infection: a primary mechanism for abnormal dopaminergic development in schizophrenia

Meyer, U., & Feldon, J. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1504-9 · Cited by 109 · see citing works

Transforming Growth Factor β Is Required for Differentiation of Mouse Mesencephalic Progenitors into Dopaminergic Neurons In Vitro and In Vivo: Ectopic Induction in Dorsal Mesencephalon

Roussa, E., Wiehle, M., Dünker, N., Becker‐Katins, S., Oehlke, O., & KRIEGLSTEIN, K. G. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0514 · Cited by 96 · see citing works

Identification ofDlk1, PtpruandKlhl1as novel Nurr1 target genes in meso-diencephalic dopamine neurons

Jacobs, F. M. J., van der Linden, A. J. A., Wang, Y., von Oerthel, L., Sul, H. S., Burbach, J. P. H., & Smidt, M. P. (2009) · Development · doi:10.1242/dev.037556 · Cited by 95 · see citing works

Transcriptional regulation of mesencephalic dopaminergic neurons: The full circle of life and death

Alavian, K. N., Scholz, C., & Simon, H. H. (2007) · Movement Disorders · doi:10.1002/mds.21640 · Cited by 91 · see citing works

Ontogeny of tyrosine hydroxylase mRNA expression in mid‐ and forebrain: Neuromeric pattern and novel positive regions

Marı́n, F., Herrero, M. T., Vyas, S., & Puelles, L. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20467 · Cited by 90 · see citing works

Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson's disease

Esteves, M., Cristóvão, A. C., Saraiva, T., Rocha, S. M., Baltazar, G., Ferreira, L., & Bernardino, L. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00020 · Cited by 88 · see citing works

Expression and function of nr4a2, lmx1b, and pitx3in zebrafish dopaminergic and noradrenergic neuronal development

Filippi, A., Dürr, K., Ryu, S., Willaredt, M. A., Holzschuh, J., & Driever, W. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-135 · Cited by 87 · see citing works

Reduction of dopamine-related transcription factors Nurr1 and NGFI-B in the prefrontal cortex in schizophrenia and bipolar disorders

Xing, G., Zhang, L., Russell, S., & Post, R. M. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2005.11.006 · Cited by 85 · see citing works

Specification of dopaminergic subsets involves interplay of En1 and Pitx3

Veenvliet, J. V., dos Santos, M. T. M. A., Kouwenhoven, W. M., von Oerthel, L., Lim, J. L., van der Linden, A. J. A., Koerkamp, M. J. A. G., Holstege, F. C. P., & Smidt, M. P. (2013) · Development · doi:10.1242/dev.094565 · Cited by 84 · see citing works

Midbrain dopaminergic neurons: control of their cell fate by the engrailed transcription factors

Simon, H. H., Thuret, S., & Alberi, L. A. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0973-8 · Cited by 82 · see citing works

Nur transcription factors in stress and addiction

Campos‐Melo, D., Galleguillos, D., Sánchez, N., Gysling, K., & Andrés, M. E. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00044 · Cited by 82 · see citing works

Transcriptional Control of the Terminal Fate of Monoaminergic Neurons

Flames, N., & Hobert, O. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113824 · Cited by 75 · see citing works

Effects on Differentiation of Embryonic Ventral Midbrain Progenitors by Lmx1a, Msx1, Ngn2, and Pitx3

Roybon, L., Hjalt, T. Å. H., Christophersen, N. S., Li, J., & Brundin, P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0311-08.2008 · Cited by 74 · see citing works

Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells

Andersson, E. K. I., Irvin, D. K., Ahlsiö, J., & Parmar, M. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.12.014 · Cited by 74 · see citing works

The role of transcription factor Pitx3 in dopamine neuron development and Parkinson's disease.

Li, J., Dani, J. A., & Le, W. (2009) · PubMed · Cited by 73 · see citing works

Gestational Restraint Stress and the Developing Dopaminergic System: An Overview

Baier, C. J., Katunar, M. R., Adrover, E., Pallarés, M. E., & Antonelli, M. C. (2012) · Neurotoxicity Research · doi:10.1007/s12640-011-9305-4 · Cited by 68 · see citing works

Genetic control of midbrain dopaminergic neuron development

Blaess, S., & Ang, S. (2015) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.169 · Cited by 69 · see citing works

VMAT2 gene expression and function as it applies to imaging β-cell mass

Harris, P. E., Ferrara, C., Barba, P., Polito, T., Freeby, M., & Maffei, A. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0242-x · Cited by 68 · see citing works

Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons

Jacobs, F. M. J., Veenvliet, J. V., Almirza, W. H. M., Hoekstra, E. J., von Oerthel, L., van der Linden, A. J. A., Neijts, R., Koerkamp, M. J. A. G., van Leenen, D., Holstege, F. C. P., et al. (2011) · Development · doi:10.1242/dev.071704 · Cited by 67 · see citing works

Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation

Willems, S., Zaienne, D., & Merk, D. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00186 · Cited by 66 · see citing works

THE DOPAMINERGIC NIGROSTRIATAL SYSTEMAND PARKINSON'S DISEASE

Hodaie, M., Neimat, J. S., & Lozano, A. M. (2007) · Neurosurgery · doi:10.1227/01.neu.0000249209.11967.cb · Cited by 66 · see citing works

Age-related changes in dopamine signaling in Nurr1 deficient mice as a model of Parkinson's disease

Zhang, L., Le, W., Xie, W., & Dani, J. A. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.022 · Cited by 65 · see citing works

Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons

Hwang, D., Hong, S., Jeong, J., Choi, S., Kim, H.-S., Kim, J., & Kim, K. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06404.x · Cited by 61 · see citing works

Decreased NURR1 and PITX3 gene expression in Chinese patients with Parkinson’s disease

Liu, H., Wei, L., Tao, Q., Deng, H., Ming, M., Xu, P., & Le, W. (2012) · European Journal of Neurology · doi:10.1111/j.1468-1331.2011.03644.x · Cited by 60 · see citing works

Nurr1 Protein Is Required for N-Methyl-d-aspartic Acid (NMDA) Receptor-mediated Neuronal Survival

Barneda‐Zahonero, B., Servitja, J., Badiola, N., Miñano-Molina, A. J., Fadó, R., Saura, C. A., & Rodrı́guez-Álvarez, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.272427 · Cited by 60 · see citing works

Neuroprotective effects of cystamine in aged parkinsonian mice

Tremblay, M.-È., Saint‐Pierre, M., Bourhis, E., Lévesque, D., Rouillard, C., & Cicchetti, F. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.04.004 · Cited by 58 · see citing works

Perinatal Heptachlor Exposure Increases Expression of Presynaptic Dopaminergic Markers in Mouse Striatum

Caudle, W. M., Richardson, J. R., Wang, M., & Miller, G. W. (2004) · NeuroToxicology · doi:10.1016/j.neuro.2004.09.003 · Cited by 56 · see citing works

Deficiency of the Housekeeping Gene Hypoxanthine–Guanine Phosphoribosyltransferase (HPRT) Dysregulates Neurogenesis

Guibinga, G.-H., Hsu, S. K., & Friedmann, T. (2009) · Molecular Therapy · doi:10.1038/mt.2009.178 · Cited by 55 · see citing works

Genetic control of dopaminergic neuron differentiation

Simeone, A. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.11.007 · Cited by 53 · see citing works

Direct Regulation of Pitx3 Expression by Nurr1 in Culture and in Developing Mouse Midbrain

Volpicelli, F., Gregorio, R. D., Pulcrano, S., Perrone‐Capano, C., di Porzio, U., & Bellenchi, G. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030661 · Cited by 52 · see citing works

Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons

McClymont, S. A., Hook, P. W., Soto, A. I., Reed, X., Law, W., Kerans, S. J., Waite, E. L., Briceno, N., Thole, J. F., Heckman, M. G., et al. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.10.018 · Cited by 50 · see citing works

Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes

Yu, H., Rubinstein, M., & Low, M. J. (2022) · eLife · doi:10.7554/elife.72883 · Cited by 50 · see citing works

Molecular mechanisms of dopaminergic subset specification: fundamental aspects and clinical perspectives

Veenvliet, J. V., & Smidt, M. P. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1681-5 · Cited by 48 · see citing works

Isolation and Culture of Ventral Mesencephalic Precursor Cells and Dopaminergic Neurons from Rodent Brains

Pruszak, J., Just, L., Ole Isacson, A., & Nikkhah, G. (2009) · Current Protocols in Stem Cell Biology · doi:10.1002/9780470151808.sc02d05s11 · Cited by 48 · see citing works

Development and Differentiation of Midbrain Dopaminergic Neuron: From Bench to Bedside

Wang, M., Ling, K., Tan, J. J., & Lu, C. (2020) · Cells · doi:10.3390/cells9061489 · Cited by 46 · see citing works

Delta‐like 1 participates in the specification of ventral midbrain progenitor derived dopaminergic neurons

Bauer, M., Szulc, J., Meyer, M., Jensen, C. H., Abbas‐Terki, T., Meixner, A., Kinkl, N., Gasser, T., Aebischer, P., & Ueffing, M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05037.x · Cited by 48 · see citing works

Nurr1 regulates RET expression in dopamine neurons of adult rat midbrain

Galleguillos, D., Fuentealba, J. A., Gómez, L. M., Saver, M., Gómez, A. V., Nash, K. R., Bürger, C., Gysling, K., & Andrés, M. E. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06841.x · Cited by 47 · see citing works

Consequences of impaired purine recycling in dopaminergic neurons

Lewers, J. C., Ceballos-Picot, I., Shirley, T. L., Mockel, L., Egami, K., & Jinnah, H. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2007.10.065 · Cited by 46 · see citing works

Dental Pulp-Derived Mesenchymal Stem Cells for Modeling Genetic Disorders

Masuda, K., Han, X., Kato, H., Sato, H., Zhang, Y., Sun, X., Hirofuji, Y., Yamaza, H., Yamada, A., & Fukumoto, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052269 · Cited by 48 · see citing works

A Nurr1 point mutant, implicated in Parkinson’s disease, uncouples ERK1/2-dependent regulation of tyrosine hydroxylase transcription

Jacobsen, K. X., MacDonald, H. R., Lemonde, S., Daigle, M., Grimes, D. A., Bulman, D. E., & Albert, P. R. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.08.003 · Cited by 46 · see citing works

Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration

Willems, S., & Merk, D. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00585 · Cited by 46 · see citing works

Midbrain dopaminergic neuron fate specification: Of mice and embryonic stem cells

Gale, E. A., & Li, M. (2008) · Molecular Brain · doi:10.1186/1756-6606-1-8 · Cited by 44 · see citing works

Molecular programming of stem cells into mesodiencephalic dopaminergic neurons

Burbach, J. P. H., & Smidt, M. P. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.09.003 · Cited by 43 · see citing works

Biological effects of pramipexole on dopaminergic neuron-associated genes: relevance to neuroprotection

Pan, T., Xie, W., Jankovic, J. J., & Le, W. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2004.11.080 · Cited by 42 · see citing works

Differentiation of dopaminergic neurons from human embryonic stem cells: Modulation of differentiation by FGF-20

Shimada, H., Yoshimura, N., Tsuji, A., & Kunisada, T. (2009) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2008.12.013 · Cited by 42 · see citing works

Heroin Abuse Is Characterized by Discrete Mesolimbic Dopamine and Opioid Abnormalities and Exaggerated Nuclear Receptor-Related 1 Transcriptional Decline with Age

Horváth, M., Kovács, G. G., Kövari, V., Majtényi, K., Hurd, Y. L., & Keller, É. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2398-07.2007 · Cited by 42 · see citing works

Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development

Chakrabarty, K., von Oerthel, L., Hellemons, A. J. C. G. M., Clotman, F., Espana, A., Koerkamp, M. J. A. G., Holstege, F. C. P., Pasterkamp, R. J., & Smidt, M. P. (2012) · Biology Open · doi:10.1242/bio.20121230 · Cited by 41 · see citing works

Development of the dopaminergic neurons in the rodent brainstem

Vitalis, T., Cases, O., & Parnavelas, J. G. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.05.044 · Cited by 41 · see citing works

The Nurr1 Ligand,1,1-bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism

Hammond, S. L., Popichak, K. A., Li, X., Hunt, L. G., Richman, E. H., Damale, P. U., Chong, E. K. P., Backos, D. S., Safe, S. H., & Tjalkens, R. B. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.246389 · Cited by 40 · see citing works

Lmx1a Encodes a Rostral Set of Mesodiencephalic Dopaminergic Neurons Marked by the Wnt/B-Catenin Signaling Activator R-spondin 2

Hoekstra, E. J., von Oerthel, L., van der Heide, L. P., Kouwenhoven, W. M., Veenvliet, J. V., Wever, I., Jin, Y.-R., Yoon, J. K., van der Linden, A. J. A., Holstege, F. C. P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074049 · Cited by 40 · see citing works

9-Methyl-β-carboline up-regulates the appearance of differentiated dopaminergic neurones in primary mesencephalic culture

Hamann, J., Wernicke, C., Lehmann, J., Reichmann, H., Rommelspacher, H., & Gille, G. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.08.018 · Cited by 39 · see citing works

Tcf12 Is Involved in Early Cell-Fate Determination and Subset Specification of Midbrain Dopamine Neurons

Mesman, S., & Smidt, M. P. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00353 · Cited by 38 · see citing works

Identification of a dopaminergic enhancer indicates complexity in vertebrate dopamine neuron phenotype specification

Fujimoto, E., Stevenson, T. J., Chien, C.-B., & Bonkowsky, J. L. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.01.023 · Cited by 37 · see citing works

Acquisition of the Midbrain Dopaminergic Neuronal Identity

Mesman, S., & Smidt, M. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134638 · Cited by 36 · see citing works

Neonatal Nicotine Exposure Primes Midbrain Neurons to a Dopaminergic Phenotype and Increases Adult Drug Consumption

Romoli, B., Lozada, A. F., Sandoval, I. M., Manfredsson, F. P., Hnasko, T. S., Berg, D. K., & Dulcis, D. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.019 · Cited by 34 · see citing works

Levodopa and pramipexole effects on presynaptic dopamine PET markers and estimated dopamine release

Sossi, V., Dinelle, K., Schulzer, M., Mak, E., Doudet, D. J., & de la Fuente‐Fernández, R. (2010) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-010-1581-3 · Cited by 35 · see citing works

ZENON, a Novel POZ Kruppel-Like DNA Binding Protein Associated with Differentiation and/or Survival of Late Postmitotic Neurons

Kiefer, H., Chatail, F., Ravassard, P., Bayard, E., Brunet, I., & Mallet, J. J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1713-1729.2005 · Cited by 35 · see citing works

FoxP1 promotes midbrain identity in embryonic stem cell‐derived dopamine neurons by regulating Pitx3

Konstantoulas, C. J., Parmar, M., & Li, M. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06650.x · Cited by 33 · see citing works

Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1

Green, A. L., Zhan, L., Eid, A., Zarbl, H., Guo, G. L., & Richardson, J. R. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.07.020 · Cited by 33 · see citing works

Transforming Growth Factor β Cooperates with Persephin for Dopaminergic Phenotype Induction

Roussa, E., Oehlke, O., Rahhal, B., Heermann, S., Heidrich, S., Wiehle, M., & KRIEGLSTEIN, K. G. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0805 · Cited by 33 · see citing works

Protective effects of a herbal extract combination of Bupleurum falcatum , Paeonia suffruticosa , and Angelica dahurica against MPTP-induced neurotoxicity via regulation of nuclear receptor-related 1 protein

Sim, Y., Park, G., Eo, H., Huh, E., Gu, P. S., Hong, S.-P., Pak, Y. K., & Oh, M. S. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.10.029 · Cited by 33 · see citing works

Nuclear receptors in neural stem/progenitor cell homeostasis

Gkikas, D., Tsampoula, M., & Politis, P. K. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2571-4 · Cited by 32 · see citing works

Anti-Parkinsonian Effects of Nurr1 Activator in Ubiquitin-Proteasome System Impairment Induced Animal Model of Parkinson’s Disease

Zhang, Z., Li, X., Xie, W., Tuo, H., Hintermann, S., Jankovic, J. J., & Le, W. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152712803581155 · Cited by 32 · see citing works

Destabilization of survival factor MEF2D mRNA by neurotoxin in models of Parkinson's disease

Wang, B., Cai, Z., Lu, F., Li, C., Zhu, X., Su, L., Gao, G., & Yang, Q. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12765 · Cited by 30 · see citing works

Cell replacement therapy for Parkinson’s disease: how close are we to the clinic?

Ganz, J., Lev, N., Melamed, E., & Offen, D. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.74 · Cited by 34 · see citing works

Exposure to Atrazine during Gestation and Lactation Periods: Toxicity Effects on Dopaminergic Neurons in Offspring by Downregulation of Nurr1 and VMAT2

Sun, Y., Li, Y., Yang, J., Yu, J., Wu, Y., & Li, B. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15022811 · Cited by 29 · see citing works

Neurochemical profiling of dopaminergic neurons in the forebrain of a cichlid fish, Astatotilapia burtoni

O’Connell, L. A., Fontenot, M. R., & Hofmann, H. A. (2013) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2012.12.007 · Cited by 29 · see citing works

Reduced tyrosine hydroxylase and GTP cyclohydrolase mRNA expression, tyrosine hydroxylase activity, and associated neurochemical alterations in Nurr1-null heterozygous mice

Eells, J. B., Misler, J. A., & Nikodem, V. M. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.05.004 · Cited by 29 · see citing works

Bipartite functions of the CREB co‐activators selectively direct alternative splicing or transcriptional activation

Amelio, A. L., Caputi, M., & Conkright, M. D. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.216 · Cited by 29 · see citing works

Role of Nurr1 in the Generation and Differentiation of Dopaminergic Neurons from Stem Cells

Rodríguez‐Traver, E., Solís, Ó., Díaz‐Guerra, E., Ortiz, Ó., Vergaño‐Vera, E., Méndez‐Gómez, H. R., García‐Sanz, P., Moratalla, R., & Vicario‐Abejón, C. (2015) · Neurotoxicity Research · doi:10.1007/s12640-015-9586-0 · Cited by 28 · see citing works

Potential effects and molecular mechanisms of melatonin on the dopaminergic neuronal differentiation of human amniotic fluid mesenchymal stem cells

Phonchai, R., Phermthai, T., Kitiyanant, N., Suwanjang, W., Kotchabhakdi, N., & Chetsawang, B. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.12.012 · Cited by 28 · see citing works

Molecular Regulation in Dopaminergic Neuron Development. Cues to Unveil Molecular Pathogenesis and Pharmacological Targets of Neurodegeneration

Volpicelli, F., Perrone‐Capano, C., Bellenchi, G. C., Colucci-D’Amato, L., & di Porzio, U. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113995 · Cited by 29 · see citing works

Nurr1 blocks the mitogenic effect of FGF ‐2 and EGF , inducing olfactory bulb neural stem cells to adopt dopaminergic and dopaminergic‐ GABA ergic neuronal phenotypes

Vergaño‐Vera, E., Díaz‐Guerra, E., Rodríguez‐Traver, E., Méndez‐Gómez, H. R., Solís, Ó., Pignatelli, J., Pickel, J. M., Lee, S., Moratalla, R., & Vicario‐Abejón, C. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22251 · Cited by 27 · see citing works

Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons

Cárdenas, O. S., Quintana-Hau, J. D. D., Le, W., Smidt, M. P., Cox, J. J., Mayo, F. J. D., Burbach, J. P. H., & Conneely, O. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.4013 · Cited by 744 · see citing works

A selective group of dopaminergic neurons express Nurr1 in the adult mouse brain

Bäckman, C. M., Perlmann, T., Wallén‐Mackenzie, Å., Hoffer, B. J., & Morales, M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02149-6 · Cited by 117 · see citing works

In vitro regulated expression of tyrosine hydroxylase in ventral midbrain neurons from Nurr1‐null mouse pups

Eells, J. B., Rives, J. E., Yeung, S. K., & Nikodem, V. M. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1082 · Cited by 20 · see citing works

Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells

Hermanson, E. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00216-7 · Cited by 162 · see citing works

The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease

Jankovic, J., Chen, S., & Le, W. D. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.09.001 · Cited by 325 · see citing works