Short-term pre-operative smoking cessation intervention does not affect postoperative complications in colorectal surgery: a randomized clinical trial
Abstract
Background Smokers have a higher risk of complicated tissue and wound healing after surgery than nonsmokers. We tested the hypothesis that short-term pre-operative cessation of smoking in colorectal surgery decreases the incidence of postoperative tissue and wound complications. Methods From February 1998 to March 2001, 60 patients, who smoked daily, undergoing colorectal resection were randomly assigned 2-3 weeks before scheduled surgery to either abstinence from smoking, counselling and nicotine replacement therapy or maintenance of daily smoking habits. Postoperative tissue and wound complications necessitating surgical or medical treatment were evaluated at discharge and 30 days after surgery by blinded outcome assessment. Results In the pre-operative period of 15 days (8-24) (median, interquartile range (IQR)), 89% of the patients in the intervention group vs. 13% in the control group abstained from smoking or reduced by more than half (P Conclusion Short-term cessation of smoking does not reduce the risk of complicated tissue and wound healing or other complications in colorectal surgery.
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Short term cessation of smoking does not effectively reduce the risk and complications during wound healing after surgery.
“reports have also suggested that short term cessation of smoking does not effectively reduce the risk and complications during wound healing after surgery [13].”
From Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing (2016) · cites this paper as [13]
Cites
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Mechanisms responsible for sympathetic activation by cigarette smoking in humans.
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Sørensen, L. T. (2012) · Archives of Surgery · doi:10.1001/archsurg.2012.5 · Cited by 645 · see citing works
Self-citationSmoking cessation reduces postoperative complications: A systematic review and meta-analysis
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Additional behavioural support as an adjunct to pharmacotherapy for smoking cessation
Hartmann-Boyce, J., Hong, B., Livingstone-Banks, J., Wheat, H., & Fanshawe, T. R. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009670.pub4 · Cited by 186 · see citing works
Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing
Dhall, S., Alamat, R., Castro, A., Sarker, A. H., Mao, J.-H., Chan, A., Hang, B., & Martins-Green, M. (2016) · Clinical Science · doi:10.1042/cs20160236 · Cited by 55 · see citing works
Fong, M., Kaner, E., Rowland, M., Graham, H. E., McEvoy, L., Hallsworth, K., Cucato, G., Gibney, C., Nedkova, M., Prentis, J., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286757 · Cited by 37 · see citing works
- Authors
- Sørensen, L. T., & Jørgensen, T.
- Affiliations
- Bispebjerg Hospital (DK)
- Corresponding author
- Sørensen, Lars Tue
- Venue
- Colorectal Disease
- Publisher
- Wiley
- Published
- 2003-06-17
- Volume
- 5
- Issue
- 4
- Pages
- 347-352
- ISSN
- 1462-8910 (ISSN-L)
- 1463-1318
- OpenAlex
- W2087879333
- Cited by
- 150
- References
- 2
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 5 · 2020: 6 · 2019: 5 · 2018: 11 · 2017: 10 · 2016: 5 · 2015: 10 · 2014: 6 · 2013: 8 · 2012: 8
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Colorectal Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Health Sciences › Medicine › Surgery › Surgical site infection prevention
- Keywords
- smoking cessation, preoperative smoking cessation, colorectal surgery, postoperative complications, wound healing, tissue repair, nicotine replacement therapy, colorectal resection
- MeSH terms
- Adult, Aged, Aged, 80 and over, Colectomy, Female, Humans, Male, Middle Aged, Nicotine, Postoperative Complications, Digestive System Surgical Procedures, Time Factors, Wound Healing, Smoking Cessation
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