Heart rate variability in patients with untreated Parkinson's disease
Abstract
The aim of this study was to evaluate cardiovascular responses as a marker of autonomic nervous system (ANS) disturbances in patients with untreated Parkinson's disease (PD) and to assess the relationship between them and the clinical characteristics of PD. The ANS functions were investigated in 50 patients with PD and 55 healthy subjects by measuring standard cardiovascular autonomic reflexes and heart rate variability (HRV) at rest using spectral analysis (the autoregressive model and the fast Fourier transformation), the percentage of the counts of beat-to-beat variation greater than 50 ms and the fractal dimension. Significantly attenuated HRV and deficient blood pressure reaction to tilting were found in the PD patient group. The patients with hypokinesia/rigidity as the initial symptom of PD had a more pronounced HRV deficit than those with tremor onset. Untreated PD patients suffer significant failure in cardiovascular nervous system regulation, and in patients with hypokinesia/rigidity as their initial disease manifestation the risk of this ANS dysfunction is high. However, in the early stages of PD these changes did not reach significance at individual level.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Prominent changes in 24-hour rhythms of heart rate and blood pressure have been repeatedly reported in Parkinson's disease.
“Similar to motor function, prominent changes in 24-hour rhythms of heart rate and blood pressure have been repeatedly reported in PD.”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Kallio et al., 2000
Studies report reversal of the normal diurnal rhythm of blood pressure with increased diurnal variability of blood pressure and elevations of overnight blood pressure, along with loss of diurnal heart rate variability and a disappearance of the sympathetic morning peak in Parkinson's disease.
“These studies report reversal of the normal diurnal rhythm of BP with increased diurnal variability of BP and elevations of overnight BP along with loss of diurnal HR variability and a disappearance of the sympathetic morning peak (Haapaniemi et al., 2001, Kallio et al., 2000, Kallio et al., 2004, Mastrocola et al., 1999).”
From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Kallio et al., 2000
Cites
Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159 · see citing works
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289 · see citing works
The Fractal Geometry of Nature
Mandelbrot, B. B., & Longley, P. (1982) · CERN Document Server (European Organization for Nuclear Research) · Cited by 5,501 · see citing works
Feder, J. (1988) · Springer eBooks · doi:10.1007/978-1-4899-2124-6 · Cited by 3,595 · see citing works
AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY
FEARNLEY, J. M., & LEES, A. J. (1991) · Brain · doi:10.1093/brain/114.5.2283 · Cited by 3,529 · see citing works
An Efficient Algorithm for Spectral Analysis of Heart Rate Variability
Berger, R. D., AKSELROD, S., Gordon, D. H., & Cohen, R. J. (1986) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.1986.325789 · Cited by 808 · see citing works
Science in Pictures: Chaos and Fractals in Human Physiology
Goldberger, A. L., Rigney, D. R., & West, B. J. (1990) · Scientific American · doi:10.1038/scientificamerican0290-42 · Cited by 805 · see citing works
Multiple Resolution Texture Analysis and Classification
Peleg, B., Naor, J. S., Hartley, R. L., & Avnir, D. (1984) · IEEE Transactions on Pattern Analysis and Machine Intelligence · doi:10.1109/tpami.1984.4767557 · Cited by 791 · see citing works
Parkinson's Disease Society Brain Bank, London: overview and research.
Daniel, S. E., & Lees, A. J. (1993) · PubMed · Cited by 598 · see citing works
Katirji, M. B. (1993) · Neurology · doi:10.1212/wnl.43.11.2429 · Cited by 589 · see citing works
Gibb, W. R. G., & Lees, A. J. (1991) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.54.5.388 · Cited by 574 · see citing works
Third symposium on Parkinson's disease
Tucker, J. S. (1970) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(70)90108-2 · Cited by 416 · see citing works
A comparison of clinical and pathological features of young‐ and old‐onset Parkinson's disease
Gibb, W. R. G., & Lees, A. J. (1988) · Neurology · doi:10.1212/wnl.38.9.1402 · Cited by 371 · see citing works
123I-metaiodobenzylguanidine myocardial scintigraphy in Parkinson's disease
Orimo, S., Ozawa, E., NAKADE, S., Sugimoto, T., & Mizusawa, H. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.67.2.189 · Cited by 356 · see citing works
Sympathetic Cardioneuropathy in Dysautonomias
Goldstein, D. S., Holmes, C. S., Cannon, R. O., Eisenhofer, G., & Kopin, I. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199703063361004 · Cited by 322 · see citing works
Myers, G. A., Martin, G. J., Magid, N. M., Barnett, P. S., Schaad, J. W., Weiss, J. S., Lesch, M., & Singer, D. H. (1986) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.1986.325694 · Cited by 318 · see citing works
AUTONOMIC FAILURE: A TEXTBOOK OF CLINICAL DISORDERS OF THE AUTONOMIC NERVOUS SYSTEM.
van Dijk, D. J. G. (2000) · Brain · doi:10.1093/brain/123.9.1972 · Cited by 297 · see citing works
Autonomic failure: A textbook of clinical disorders of the autonomic nervous system
Toole, J. F. (1993) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(93)90257-y · Cited by 289 · see citing works
Autonomic Deficits in Parkinson's Syndrome
Appenzeller, O., & Goss, J. E. (1971) · Archives of Neurology · doi:10.1001/archneur.1971.00480310078007 · Cited by 177 · see citing works
Autonomic dysfunction in Parkinson's disease
Micieli, G., Tosi, P., Marcheselli, S., & Cavallini, A. (2003) · Neurological Sciences · doi:10.1007/s100720300035 · Cited by 157 · see citing works
Turner, J. (1974) · PubMed · Cited by 149 · see citing works
van Dijk, J. G., Haan, J., Zwinderman, A. H., Kremer, B. P. H., van Hilten, B. J., & Roos, R. A. C. (1993) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.56.10.1090 · Cited by 127 · see citing works
ORTHOSTATIC HYPOTENSION IN PARKINSON'S DISEASE
Gross, M., Bannister, R., & Godwin-Austen, R. B. (1972) · The Lancet · doi:10.1016/s0140-6736(72)90571-5 · Cited by 120 · see citing works
Hakusui, S., Yasuda, T., Yanagi, T., Tohyama, J., Hasegawa, Y., Koike, Y., Hirayama, M., & Takahashi, A. (1994) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(94)90023-x · Cited by 102 · see citing works
Korpelainen, J. T., Sotaniemi, K. A., & Myllylä, V. V. (1993) · Neurology · doi:10.1212/wnl.43.6.1211 · Cited by 88 · see citing works
Selegiline diminishes cardiovascular autonomic responses in Parkinson's disease
Turkka, J. T., Suominen, K., Tolonen, U., Sotaniemi, K. A., & Myllylä, V. V. (1997) · Neurology · doi:10.1212/wnl.48.3.662 · Cited by 79 · see citing works
Bordet, R., Benhadjali, J., Destée, A., Hurtevent, J. F., Bourriez, J. L., & Guieu, J. D. (1996) · Movement Disorders · doi:10.1002/mds.870110309 · Cited by 61 · see citing works
Autonomic Functions in the Early Stages of Parkinson's Disease
Awerbuch, G. I., & Sandyk, R. (1992) · International Journal of Neuroscience · doi:10.3109/00207459209000530 · Cited by 55 · see citing works
Autonomic dysfunction in recent onset and advanced Parkinson's disease
Piha, S. J., Rinne, J. O., Rinne, U. K., & Seppänen, A. (1988) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(88)90025-x · Cited by 51 · see citing works
Diehl, R. R., Linden, D., & Berlit, P. (1997) · Clinical Autonomic Research · doi:10.1007/bf02308840 · Cited by 34 · see citing works
Suominen, K. (1997) · International journal of clinical monitoring and computing · doi:10.1007/bf03356567 · Cited by 12 · see citing works
Dysfunction of the autonomic nervous system after stroke
Naver, H. (1996) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 33 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
'The clocks that time us'—circadian rhythms in neurodegenerative disorders
Videnović, A., Lázár, A. S., Barker, R. A., & Overeem, S. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.206 · Cited by 373 · see citing works
Cygankiewicz, I., & Zaręba, W. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53491-0.00031-6 · Cited by 323 · see citing works
Circadian and sleep disorders in Parkinson's disease
Videnović, A., & Golombek, D. A. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.08.018 · Cited by 247 · see citing works
Neural control of the heart: Recent concepts and clinical correlations
Palma, J.-A., & Benarroch, E. E. (2014) · Neurology · doi:10.1212/wnl.0000000000000605 · Cited by 237 · see citing works
Gjerløff, T., Fedorova, T. D., Knudsen, K., Munk, O. L., Nahimi, A., Jacobsen, S., Danielsen, E. H., Terkelsen, A. J., Hansen, J., Pavese, N., et al. (2014) · Brain · doi:10.1093/brain/awu369 · Cited by 157 · see citing works
Barbic, F., Perego, F., Canesi, M., Gianni, M., Biagiotti, S., Costantino, G., Pezzoli, G., Porta, A., Malliani, A., & Furlan, R. (2006) · Hypertension · doi:10.1161/01.hyp.0000250939.71343.7c · Cited by 137 · see citing works
Reinertsen, E., & Clifford, G. D. (2018) · Physiological Measurement · doi:10.1088/1361-6579/aabf64 · Cited by 136 · see citing works
Multi-organ autonomic dysfunction in Parkinson disease
Jain, S. (2010) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2010.08.022 · Cited by 117 · see citing works
Erb, M. K., Karlin, D. R., Ho, B. K., Thomas, K. C., Parisi, F., Vergara-Diaz, G. P., Daneault, J., Wacnik, P. W., Zhang, H., Kangarloo, T., et al. (2020) · npj Digital Medicine · doi:10.1038/s41746-019-0214-x · Cited by 116 · see citing works
Haensch, C., Lerch, H., Jörg, J., & Isenmann, S. (2008) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2008.04.031 · Cited by 107 · see citing works
Camargo, S. M. R., Vuille-dit-Bille, R. N., Mariotta, L., Ramadan, T., Huggel, K., Singer, D., Götze, O., & Verrey, F. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.216317 · Cited by 98 · see citing works
Zis, P., Erro, R., Walton, C. C., Sauerbier, A., & Chaudhuri, К. R. (2015) · npj Parkinson s Disease · doi:10.1038/npjparkd.2015.13 · Cited by 98 · see citing works
Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's disease
Valappil, R. A., Black, J. E., Broderick, M. J., Carrillo, O., Frenette, E., Sullivan, S. S., Goldman, S. M., Tanner, C. M., & Langston, J. W. (2010) · Movement Disorders · doi:10.1002/mds.23348 · Cited by 90 · see citing works
A New Perspective for Parkinson’s Disease: Circadian Rhythm
Li, S., Wang, Y., Wang, F., Hu, L., & Liu, C. (2016) · Neuroscience Bulletin · doi:10.1007/s12264-016-0089-7 · Cited by 86 · see citing works
Porta, A., Castiglioni, P., Rienzo, M. D., Bari, V., Bassani, T., Marchi, A., Takahashi, A. C. D. M., Tobaldini, E., Montano, N., Catai, A. M., et al. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00755.2012 · Cited by 82 · see citing works
Heart Rate Variability Analyses in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Heimrich, K. G., Lehmann, T., Schlattmann, P., & Prell, T. (2021) · Brain Sciences · doi:10.3390/brainsci11080959 · Cited by 82 · see citing works
Shibata, M., Morita, Y., Shimizu, T., Takahashi, K., & Suzuki, N. (2008) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2008.09.005 · Cited by 81 · see citing works
Circadian heart rate variability in Parkinson's disease
Pursiainen, V., Haapaniemi, T., Korpelainen, J. T., Huikuri, H. V., Sotaniemi, K. A., & Myllylä, V. V. (2002) · Journal of Neurology · doi:10.1007/s00415-002-0884-0 · Cited by 79 · see citing works
Consequences of Circadian Disruption on Neurologic Health
Videnović, A., & Zee, P. C. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.08.004 · Cited by 75 · see citing works
Willison, L. D., Kudo, T., Loh, D. H., Kuljis, D. A., & Colwell, C. S. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.01.014 · Cited by 71 · see citing works
Degeneration of Dopaminergic Neurons Due to Metabolic Alterations and Parkinson’s Disease
Song, J., & Kim, J. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00065 · Cited by 66 · see citing works
Circadian dysregulation in Parkinson's disease
Videnovic, A., & Golombek, D. (2017) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2016.11.001 · Cited by 63 · see citing works
Mining Physiological Conditions from Heart Rate Variability Analysis
Lin, C., Wang, J.-S., & Chung, P. (2010) · IEEE Computational Intelligence Magazine · doi:10.1109/mci.2009.935309 · Cited by 63 · see citing works
French, I. T., & Muthusamy, K. A. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00114 · Cited by 64 · see citing works
Cardiovascular dysautonomia in de novo Parkinson’s disease without orthostatic hypotension
Oka, H., Toyoda, C., Yogo, M., & Mochio, S. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2010.03135.x · Cited by 57 · see citing works
Maetzler, W., Karam, M., Berger, M. F., Heger, T., Maetzler, C., Ruediger, H., Bronzova, J., Lobo, P. P., Ferreira, J. J., Ziemssen, T., et al. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1276-1 · Cited by 54 · see citing works
Basal Ganglia and Functions of the Autonomic Nervous System
Pazo, J. H., & Belforte, J. E. (2002) · Cellular and Molecular Neurobiology · doi:10.1023/a:1021844605250 · Cited by 53 · see citing works
Attenuated heart rate response in REM sleep behavior disorder and Parkinson's disease
Sørensen, G. L., Kempfner, J., Zoetmulder, M., Sørensen, H. B. D., & Jennum, P. (2012) · Movement Disorders · doi:10.1002/mds.25012 · Cited by 52 · see citing works
Medulla oblongata damage and cardiac autonomic dysfunction in Parkinson disease
Pyatigorskaya, N., Mongin, M., Valabrègue, R., Yahia‐Cherif, L., Ewenczyk, C., Poupon, C., Debellemanière, E., Vidailhet, M., Arnulf, I., & Lehéricy, S. (2016) · Neurology · doi:10.1212/wnl.0000000000003426 · Cited by 50 · see citing works
Parasympathetic but not sympathetic cardiac dysfunction at early stages of Parkinson’s disease
Buob, A., Winter, H., Kindermann, M., Becker, G., Möller, J. C., Oertel, W. H., & Böhm, M. (2010) · Clinical Research in Cardiology · doi:10.1007/s00392-010-0170-6 · Cited by 48 · see citing works
Autonomic insufficiency in pupillary and cardiovascular systems in Parkinson’s disease
Jain, S., Siegle, G. J., Gu, C., Moore, C. G., Ivanco, L. S., Jennings, J. R., Steinhauer, S. R., Studenski, S. A., & Greenamyre, J. T. (2010) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2010.11.005 · Cited by 45 · see citing works
Comparison of heart rate variability analysis methods in patients with Parkinson's disease
Kallio, M., Suominen, K., Bianchi, A. M., Mäkikallio, T. H., Haapaniemi, T., Astafiev, S. V., Sotaniemi, K. A., Myllylä, V. V., & Tolonen, U. (2002) · Medical & Biological Engineering & Computing · doi:10.1007/bf02345073 · Cited by 44 · see citing works
Cardiac parasympathetic dysfunction in the early phase of Parkinson’s disease
Suzuki, M., Nakamura, T., Hirayama, M., Ueda, M. U., Katsuno, M., & Sobue, G. (2016) · Journal of Neurology · doi:10.1007/s00415-016-8348-0 · Cited by 43 · see citing works
Ke, J.-Q., Shao, S.-M., Zheng, Y., Fu, F., Zheng, G., & Liu, C. (2017) · Medicine · doi:10.1097/md.0000000000006523 · Cited by 42 · see citing works
Orthostatic Hypotension in Patients with Parkinson’s Disease and Atypical Parkinsonism
Fereshtehnejad, S., & Lökk, J. (2014) · Parkinson s Disease · doi:10.1155/2014/475854 · Cited by 40 · see citing works
The relevance of pre-motor symptoms in Parkinson’s disease
Visanji, N. P., & Marras, C. (2015) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2015.1083423 · Cited by 38 · see citing works
Liu, Y., Niu, L., Liu, X., Cheng, C., & Le, W. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00711-x · Cited by 39 · see citing works
Kasanuki, K., Iseki, E., Fujishiro, H., Ando, S., Sugiyama, H., Kitazawa, M., Chiba, Y., Sato, K., & Arai, H. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.04.024 · Cited by 37 · see citing works
Orthostatic heart rate variability analysis in idiopathic Parkinson's disease
Mihçi, E., Kardelen, F., Dora, B., & Balkan, S. (2006) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00580.x · Cited by 37 · see citing works
Sauvageot, N., Vaillant, M., & Diederich, N. J. (2011) · Movement Disorders · doi:10.1002/mds.23479 · Cited by 37 · see citing works
Central modulation of parasympathetic outflow is impaired in de novo Parkinson's disease patients
Tessa, C., Toschi, N., Orsolini, S., Valenza, G., Lucetti, C., Barbieri, R., & Diciotti, S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210324 · Cited by 36 · see citing works
Are Sleep Disturbances Preclinical Markers of Parkinson’s Disease?
dos Santos, A. B., Kohlmeier, K. A., & Barreto, G. E. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1488-7 · Cited by 34 · see citing works
Clinical correlates of cerebral white matter abnormalities in patients with Parkinson's disease
ten Harmsen, B. L., van Rumund, A., Aerts, M. B., Bergkamp, M. I., Esselink, R. A. J., Richard, E., Meijer, F. J. A., Bloem, B. R., & van Wamelen, D. J. (2017) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2017.12.029 · Cited by 33 · see citing works
Sabino‐Carvalho, J. L., & Vianna, L. C. (2020) · SAGE Open Medicine · doi:10.1177/2050312120921603 · Cited by 32 · see citing works
Autonomic Function in Patients With Parkinson’s Disease: From Rest to Exercise
Sabino‐Carvalho, J. L., Fisher, J. P., & Vianna, L. C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.626640 · Cited by 33 · see citing works
Cardiac autonomic impairment during sleep is linked with disease severity in Parkinson’s disease
Palma, J., Urrestarazu, E., Alegre, M., Pastor, M. A., Valencia, M., Artieda, J., & Iriarte, J. (2013) · Clinical Neurophysiology · doi:10.1016/j.clinph.2012.12.042 · Cited by 33 · see citing works
Zakrzewska‐Pniewska, B., & Jamrozik, Z. (2003) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(02)00032-9 · Cited by 32 · see citing works
Rocchi, C., Pierantozzi, M., Galati, S., Chiaravalloti, A., Pisani, V., Prosperetti, C., Lauretti, B., Stampanoni Bassi, M., Olivola, E., Schillaci, O., et al. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12437 · Cited by 31 · see citing works
Ziomber, A., Thor, P. J., Krygowska‐Wajs, A., Załęcki, T., Moskała, M. M., Romańska, I., Michaluk, J., & Antkiewicz‐Michaluk, L. (2012) · Pharmacological Reports · doi:10.1016/s1734-1140(12)70933-7 · Cited by 30 · see citing works
Heart-brain synchronization breakdown in Parkinson’s disease
Iniguez, M., Jiménez-Marín, A., Erramuzpe, A., Acera, M., Tijero, B., Murueta‐Goyena, A., Pino, R. D., Fernández, T., Carmona‐Abellán, M., Cabrera‐Zubizarreta, A., et al. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00323-w · Cited by 30 · see citing works
Monitoring Online Training Behaviors: Awareness of Electronic Surveillance Hinders E‐Learners1
Thompson, L. F., Sebastianelli, J., & Murray, N. P. (2009) · Journal of Applied Social Psychology · doi:10.1111/j.1559-1816.2009.00521.x · Cited by 29 · see citing works
Goldstein, D. S. (2013) · Comprehensive physiology · doi:10.1002/cphy.c130006 · Cited by 31 · see citing works
Nocturnal cardiac autonomic regulation in Parkinson's disease
Suominen, K., Haapaniemi, T., Sotaniemi, K., Myllyl�, V. V., Astafiev, S., Tolonen, U., & Kallio, M. (2004) · Clinical Autonomic Research · doi:10.1007/s10286-004-0173-3 · Cited by 27 · see citing works
Self-citationHeart rate variability as an indicator of pre-competitive arousal.
Murray, N. P., & Raedeke, T. D. (2008) · International journal of sport psychology · Cited by 27 · see citing works
Miyagi, T., Yamazato, M., Nakamura, T., Tokashiki, T., Namihira, Y., Kokuba, K., Ishihara, S., Sakima, H., & Ohya, Y. (2022) · BMC Neurology · doi:10.1186/s12883-022-02872-2 · Cited by 26 · see citing works
Yalçın, M., Malhan, D., Basti, A., Peralta, A. R., Ferreira, J. J., & Relógio, A. (2021) · Cancers · doi:10.3390/cancers13235978 · Cited by 24 · see citing works
Neurotrophic Factors in Autonomic Nervous System Plasticity and Dysfunction
Mattson, M. P., & Wan, R. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-007-8021-y · Cited by 24 · see citing works
Heart rate variability in leucine‐rich repeat kinase 2‐associated Parkinson's disease
Visanji, N. P., Bhudhikanok, G. S., Mestre, T., Ghate, T., Udupa, K., AlDakheel, A., Connolly, B. S., Gasca‐Salas, C., Kern, D. S., Jain, J., et al. (2017) · Movement Disorders · doi:10.1002/mds.26896 · Cited by 23 · see citing works
Dopamine receptor agonists differ in their actions on cardiac ion channels
Hurst, R. S., Higdon, N. R., Lawson, J. A., Clark, M. A., Rutherford-Root, K. L., McDonald, W. G., Haas, J. V., McGrath, J. P., & Meglasson, M. D. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.09.054 · Cited by 23 · see citing works
Yalçın, A., Atmış, V., Cengiz, O. K., Çınar, E., Aras, S., Varlı, M., & Atlı, T. (2016) · Aging and Disease · doi:10.14336/ad.2015.0819 · Cited by 23 · see citing works
Carandina, A., Lazzeri, G., Rodrigues, G. D., Franco, G., Monfrini, E., Arienti, F., Frattini, E., Trezzi, I., Soares, P. P. D. S., Bellocchi, C., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.842498 · Cited by 18 · see citing works
Cardiovascular variability in Parkinson’s disease and extrapyramidal motor slowing
Brown, R., Duma, S. R., Piguet, O., Broe, G. A., & Macefield, V. G. (2012) · Clinical Autonomic Research · doi:10.1007/s10286-012-0163-9 · Cited by 17 · see citing works
Naranjo, C. C., Marras, C., Visanji, N. P., Cornforth, D. J., Sanchez-Rodriguez, L. M., Schüle, B., Goldman, S. M., Estévez, M., Stein, P. K., Lang, A. E., et al. (2019) · Clinical Autonomic Research · doi:10.1007/s10286-019-00632-w · Cited by 17 · see citing works
Bassani, T., Bari, V., Marchi, A., Tassin, S., Vecchia, L. A. D., Canesi, M., Barbic, F., Furlan, R., & Porta, A. (2014) · Physiological Measurement · doi:10.1088/0967-3334/35/7/1397 · Cited by 16 · see citing works
Mechanical somatosensory stimulation decreases blood pressure in patients with Parkinson's disease
Zamunér, A. R., Shiffer, D., Barbic, F., Minonzio, M., Andrade, C. P., Corato, M. D., Lalli, S., Dipaola, F., Cairo, B., Albanese, A., et al. (2019) · Journal of Hypertension · doi:10.1097/hjh.0000000000002084 · Cited by 15 · see citing works
Naranjo, C. C., Marras, C., Visanji, N. P., Cornforth, D. J., Sanchez-Rodriguez, L. M., Schüle, B., Goldman, S. M., Estévez, M., Stein, P. K., Lang, A. E., et al. (2021) · Clinical Autonomic Research · doi:10.1007/s10286-021-00815-4 · Cited by 14 · see citing works
Cardiovascular variability in Mexican patients with Parkinson's disease
Delgado‐García, G. R., Estañol, B., Rodríguez‐Violante, M., Martínez‐Memije, R., Infante, Ó., & Bertado-Ramírez, N. R. (2014) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20140125 · Cited by 14 · see citing works
Myocardial123I-MIBG Uptake and Cardiovascular Autonomic Function in Parkinson’s Disease
Katagiri, A., Asahina, M., Araki, N., Poudel, A., Fujinuma, Y., Yamanaka, Y., & Kuwabara, S. (2015) · Parkinson s Disease · doi:10.1155/2015/805351 · Cited by 14 · see citing works
Measures of Heart Rate Variability in Patients with Idiopathic Parkinson’s Disease
Soares, F. H. R. (2013) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000130 · Cited by 12 · see citing works
Haensch, C., & Jörg, J. (2005) · Movement Disorders · doi:10.1002/mds.20744 · Cited by 12 · see citing works
Pancreatic Polypeptide in Parkinson’s Disease: A Potential Marker of Parasympathetic Denervation
Knudsen, K., Hartmann, B., Fedorova, T. D., Østergaard, K., Krogh, K., Møller, N., Holst, J. J., & Borghammer, P. (2017) · Journal of Parkinson s Disease · doi:10.3233/jpd-171189 · Cited by 10 · see citing works
Influence of left versus right hemibody onset Parkinson's disease on cardiovascular control
Foster, P. S., Drago, V., Harrison, D. W., Skidmore, F. M., Crucian, G. P., & Heilman, K. M. (2010) · Laterality Asymmetries of Body Brain and Cognition · doi:10.1080/13576500903483507 · Cited by 10 · see citing works
Sympathetic dysfunction as an early indicator of autonomic involvement in Parkinson’s disease
Park, J., Okamoto, L. E., Kim, S.-H., Lee, C., Park, K. W., Baek, S., Sung, J. H., Jeon, N.-J., Koh, S., Gamboa, A. C., et al. (2024) · Clinical Autonomic Research · doi:10.1007/s10286-024-01031-6 · Cited by 8 · see citing works
Biomarkers for the diagnosis and management of Parkinson's disease
Waragai, M., Sekiyama, K., Fujita, M., Tokuda, T., & Hashimoto, M. (2012) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530059.2013.733694 · Cited by 8 · see citing works
Chen, S.-Y., Yang, C. C. H., Kuo, T. B. J., & Harnod, T. (2011) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2011.07.007 · Cited by 7 · see citing works
The Motor, Cognitive, Affective, and Autonomic Functions of the Basal Ganglia
Moustafa, A. A., Mandali, A., Balasubramani, P. P., & Chakravarthy, V. S. (2018) · Cognitive science and technology · doi:10.1007/978-981-10-8494-2_3 · Cited by 7 · see citing works
The brain and heart-axis in neurodegeneration and cardiovascular disease
Sian‐Hülsmann, J., & Riederer, P. F. (2025) · Journal of Neural Transmission · doi:10.1007/s00702-025-03023-w · Cited by 6 · see citing works
Park, M., Kim, S.-W., Hong, J. Y., Cho, S. P., Park, J. H., Urtnasan, E., & Baek, M. S. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1530240 · Cited by 5 · see citing works
Goldstein, D. S. (2013) · Comprehensive physiology · doi:10.1002/j.2040-4603.2013.tb00532.x · Cited by 5 · see citing works
Evaluating subjective domains of antipsychotic‐induced adverse effects using heart rate variability
Chang, J. S., Hwang, S. S., Yi, S. H., Kim, Y., Lee, Y. S., Kim, Y. S., & Jung, H. (2014) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12226 · Cited by 5 · see citing works
Lukhanina, E. P., Мельник, Н. А., Berezetskaya, N. M., & In, K. (2008) · Neurophysiology · doi:10.1007/s11062-008-9016-5 · Cited by 5 · see citing works
Orthostatic Hypotension in Parkinson's Disease
Perez‐Lloret, S., Rey, M. V., Traon, A. P., & Rascol, O. (2013) · Neurodegenerative Disease Management · doi:10.2217/nmt.13.30 · Cited by 5 · see citing works
Haapaniemi, T. (2001) · Cited by 5 · see citing works
Correlation of motor symptoms and cardiovascular dysfunction in Parkinson’s disease
Pilipovich, A. A., Ov, V., & Makarov, S. A. (2025) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202512504159 · Cited by 4 · see citing works
Berkebile, J. A., Inan, O. T., & Beach, P. A. (2025) · Frontiers in Network Physiology · doi:10.3389/fnetp.2025.1543838 · Cited by 4 · see citing works
Autonomic dysfunction and peripheral nerve involvement in patients with Parkinson's disease
Matei, D., Luca, C. M., Andriţoi, D., Fuior, R., Zaharia, D., Onu, I., & Corciovă, C. (2019) · Balneo Research Journal · doi:10.12680/balneo.2019.240 · Cited by 4 · see citing works
Ukraintseva, Y. V., & Kovalzon, V. M. (2016) · Human Physiology · doi:10.1134/s0362119716040137 · Cited by 4 · see citing works
Perez‐Lloret, S., Rey, M. V., Traon, A. P., & Rascol, O. (2014) · Expert Opinion on Orphan Drugs · doi:10.1517/21678707.2014.901167 · Cited by 4 · see citing works
Unobtrusive real-time heart rate variability analysis for the detection of orthostatic dysregulation
Richer, R., Groh, B. H., Blank, P., Dorschky, E., Martindale, C. F., Klucken, J., & Eskofier, B. M. (2016) · Wearable and Implantable Body Sensor Networks · doi:10.1109/bsn.2016.7516257 · Cited by 4 · see citing works
Porta, A., Cairo, B., Bari, V., Arduino, C., Burzo, I., MARIA, B. D., Castiglioni, P., Quintin, L., Catai, A. M., Barbic, F., et al. (2026) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2026.111473 · Cited by 3 · see citing works
Sabino‐Carvalho, J. L., Guerrero, R. V. D., Teixeira, A. L. D. S., Brandão, P. R. D. P., & Vianna, L. C. (2025) · Autonomic Neuroscience · doi:10.1016/j.autneu.2025.103311 · Cited by 3 · see citing works
Kalampokini, S., Pilavas, A., Tsalamandris, G., Hadjigeorgiou, G. M., & Bargiotas, P. (2025) · Chronobiology International · doi:10.1080/07420528.2025.2515972 · Cited by 2 · see citing works
Circadian disruption and its clinical implications in Parkinson's disease: A Narrative review
Kataoka, H., Saeki, K., Sugie, K., & Obayashi, K. (2026) · Sleep Medicine · doi:10.1016/j.sleep.2026.108928 · Cited by 2 · see citing works
Circadian rhythm abnormalities
Chahine, L. M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-67374-7.00009-2 · Cited by 2 · see citing works
Evaluation of Autonomic Dysfunction in Parkinson Disease by Cardiovascular Autonomic Indexes
Kang, Y. J., Lee, S.-W., Park, J. H., & Lee, T. K. (2015) · Journal of the Korean Neurological Association · doi:10.17340/jkna.2015.4.7 · Cited by 1 · see citing works
“Bicycle” Model for Interdisciplinary approach in Parkinson’s Disease
Guerra, T. D. R. B., Orsini, M., Azizi, M. A. A., do Nascimento, J. S. F., Gonçalves, T. R., Nunes, N. D. S. M., de Castro, R. R. T., & Moreno, A. M. (2020) · International Journal of Advanced Engineering Research and Science · doi:10.22161/ijaers.711.32 · Cited by 1 · see citing works
Astrand test: a comparison between patients with Parkinson's Disease and healthy controls
Horst, E. (2011) · Utrecht University Repository (Utrecht University) · Cited by 1 · see citing works
Anatomo-functional basis of nonmotor symptoms in Parkinson disease
Mano, T., Britton, Z., & Britton, T. C. (2016) · Neurology · doi:10.1212/wnl.0000000000003443 · Cited by 1 · see citing works
The Influence of Concurrent Visual Feedback During Treadmill Training in Parkinson’s Disease
Johnston, R. E. (2009) · Scholars Commons (Wilfrid Laurier University)
Role of Trichloroethylene in Parkinson’s Disease
Goldman, S. M., & Cash, S. W. (2014) · Molecular and integrative toxicology · doi:10.1007/978-1-4471-6311-4_6
- Authors
- Kallio, M., Haapaniemi, T., Turkka, J., Suominen, K., Tolonen, U., Sotaniemi, K., Heikkilä, V. ‐., & Myllylä, V.
- Affiliations
- University of Oulu (FI)
- Corresponding author
- Kallio, M.
- ORCID
- Kallio, M.
- Venue
- European Journal of Neurology
- Publisher
- Wiley
- Published
- 2000-12
- Volume
- 7
- Issue
- 6
- Pages
- 667-672
- ISSN
- 1351-5101 (ISSN-L)
- 1468-1331
- OpenAlex
- W2007990975
- Cited by
- 115
- References
- 33
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 2 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 12 · 2015: 8 · 2014: 13 · 2013: 7 · 2012: 7
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Keywords
- Parkinson's disease, heart rate variability, autonomic dysfunction, untreated Parkinson's disease, fractal dimension, beat-to-beat variation
- MeSH terms
- Adult, Aged, Autonomic Nervous System, Blood Pressure, Female, Heart Rate, Humans, Male, Middle Aged, Parkinson Disease, Reference Values, Valsalva Maneuver, Tilt-Table Test
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
