CoChat
Sign Up
Cited by 27Heart Rate Variability and Autonomic ControlParkinson's Disease Mechanisms and TreatmentsCardiovascular Syncope and Autonomic Disorders

Nocturnal cardiac autonomic regulation in Parkinson's disease

Suominen, Kalervo, Haapaniemi, Tarja, Sotaniemi, Ky�sti, Myllyl�, Vilho V., Astafiev, Serguei, Tolonen, Uolevi, Kallio, Mika·2004·Clinical Autonomic Research
DOI 10.1007/s10286-004-0173-3
Open this paper in CoChat — free account

Abstract

Diminished heart rate (HR) variability has been reported in patients with early phase Parkinson's disease (PD) using standardized cardiovascular reflex tests. However, limited data exist on HR variability during sleep; thus the present study was performed to investigate the characteristics of HR variability during different sleep stages. The HR variability of 21 newly diagnosed and untreated PD patients and of 22 control subjects was evaluated by using time domain, frequency domain and non-linear methods and by analyzing HR reactions to body movements during the different sleep stages (non-REM stages S1-4 and the REM stage). The nocturnal cardiac autonomic control was disturbed in PD patients compared to controls both during sleep and waking. HR reactions to body movements were decreased especially during REM sleep referring to defective sympathetic cardiovascular control. High frequency spectral power of HR variability was attenuated in the patients in waking and during non-REM sleep but not during REM sleep suggesting that parasympathetic cardiovascular control is also affected in early PD. However, the variance of R-R intervals during non-REM sleep was significantly increased in PD patients. Especially during this sleep stage the patients also moved more than the controls. HR variability is decreased not only in waking but also during sleep in PD patients. However, the increased variance of HR during non-REM sleep refers that in early phase of PD cardiovascular system is still able to react to changing body circumstances. Furthermore, our findings suggest that the indicators measuring the dominant sympathetic or parasympathetic activity of each given sleep stage are the most sensitive measures in revealing disturbed nocturnal ANS function.

Integrity signals

Registry

Crossref · 10.1007/s10286-004-0173-3

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Prominent changes in 24-hour rhythms of heart rate and blood pressure have been repeatedly reported in Parkinson's disease.

    “Similar to motor function, prominent changes in 24-hour rhythms of heart rate and blood pressure have been repeatedly reported in PD.”

    From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Kallio et al., 2004

  • Studies report reversal of the normal diurnal rhythm of blood pressure with increased diurnal variability of blood pressure and elevations of overnight blood pressure, along with loss of diurnal heart rate variability and a disappearance of the sympathetic morning peak in Parkinson's disease.

    “These studies report reversal of the normal diurnal rhythm of BP with increased diurnal variability of BP and elevations of overnight BP along with loss of diurnal HR variability and a disappearance of the sympathetic morning peak (Haapaniemi et al., 2001, Kallio et al., 2000, Kallio et al., 2004, Mastrocola et al., 1999).”

    From Circadian dysregulation in Parkinson's disease (2017) · cites this paper as Kallio et al., 2004

Cites

Flagged first, then by citations

2 of the 35 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Suominen, K., Haapaniemi, T., Sotaniemi, K., Myllyl�, V. V., Astafiev, S., Tolonen, U., & Kallio, M.
Affiliations
  • Oulu University Hospital (FI)
  • University of Oulu (FI)
Corresponding author
Kallio, Mika
ORCID
Venue
Clinical Autonomic Research
Publisher
Springer Science and Business Media LLC
Published
2004-04-01
Volume
14
Issue
2
Pages
119-124
ISSN
  • 0959-9851 (ISSN-L)
  • 1619-1560
DOI
10.1007/s10286-004-0173-3
OpenAlex
W1996474930
Cited by
27
References
35
Citations by year
2026: 1 · 2025: 4 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 1 · 2016: 2 · 2015: 1 · 2013: 3 · 2012: 1
FWCI
0.87
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Clinical Autonomic Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
Keywords
Parkinson's disease, heart rate variability, sleep stages, REM sleep, NREM sleep, RR interval variability, early-stage Parkinson's disease
MeSH terms
Adult, Aged, Autonomic Nervous System, Circadian Rhythm, Female, Heart, Heart Rate, Humans, Male, Middle Aged, Movement, Parkinson Disease, Sleep, REM, Wakefulness

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review