‘Gender gap’ in multiple sclerosis: magnetic resonance imaging evidence
Abstract
The authors evaluated the gender difference in the magnetic resonance imaging characteristics of the lesions occurring in the brain of 413 multiple sclerosis (MS) patients. Men had fewer contrast‐enhancing lesions ( P = 0.01), but a higher proportion of lesions evolving into ‘black holes’ ( P = 0.001), when compared with women. Thus, our data indicate that men with MS are prone to develop less inflammatory, but more destructive lesions than women. This study results provides support for a modulation of the MS pathological changes by gender.
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Men with MS may develop less inflammatory but more destructive lesions.
“This suggests that men with MS may develop less inflammatory but more destructive lesions.”
From SJL Mice Exposed to Cuprizone Intoxication Reveal Strain and Gender Pattern Differences in Demyelination (2009) · cites this paper as [47]
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Taylor, L. C., Gilmore, W., & Matsushima, G. K. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00230.x · Cited by 84 · see citing works
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- Authors
- Pozzilli, C., Tomassini, V., Marinelli, F., Paolillo, A., Gasperini, C., & Bastianello, S.
- Affiliations
- Sapienza University of Rome (IT)
- Azienda Ospedaliera San Camillo-Forlanini (IT)
- Corresponding author
- Pozzilli, C.
- Venue
- European Journal of Neurology
- Publisher
- Wiley
- Published
- 2003-01
- Volume
- 10
- Issue
- 1
- Pages
- 95-97
- ISSN
- 1351-5101 (ISSN-L)
- 1468-1331
- OpenAlex
- W2040286508
- Cited by
- 154
- References
- 0
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 4 · 2023: 8 · 2022: 12 · 2021: 7 · 2020: 8 · 2019: 7 · 2018: 5 · 2017: 2 · 2016: 8 · 2015: 8 · 2014: 11 · 2013: 5 · 2012: 9
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neurology (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Health Sciences › Medicine › Oncology › Polyomavirus and related diseases
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- multiple sclerosis, sex differences, brain lesions, contrast-enhancing lesions, black holes, lesion evolution, gender gap
- MeSH terms
- Adult, Cross-Sectional Studies, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Sex Characteristics, Cohort Studies, Chi-Square Distribution, Statistics, Nonparametric
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