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Cited by 383

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Depression and anxiety disorders associated with headache frequency. The Nord‐Trøndelag Health Study

Zwart, J.‐A., Dyb, G., Hagen, K., Ødegård, K. J., Dahl, A. A., Bovim, G., Stovner, L. J.·2003·European Journal of Neurology

Abstract

The aim of this large cross‐sectional population‐based study was to examine the association between migraine, non‐migrainous headache and headache frequency with depression, and anxiety disorders. From 1995 to 1997, all 92 566 inhabitants aged 20 years and above in Nord‐Trøndelag County in Norway were invited to participate in the Nord‐Trøndelag Health Study (‘Helseundersøkelsen i Nord‐Trøndelag’ = HUNT‐2). A total of 64 560 participated, whereof 51 383 subjects (80%) completed a headache questionnaire that was included. Of these 51 383 individuals, 47 257 (92%) completed the depression subscale items and 43 478 (85%), the anxiety subscale items of the Hospital Anxiety and Depression Scale (HADS). Associations were assessed in multivariate analyses, estimating prevalence odds ratios (OR) with 95% confidence intervals (CI). Depression and anxiety disorders as measured by HADS, were significantly associated with migraine (OR = 2.7, 95% CI 2.3–3.2; OR = 3.2, 95% CI 2.8–3.6) and non‐migrainous headache (OR = 2.2, 95% CI 2.0–2.5; OR = 2.7, 95% CI 2.4–3.0) when compared with headache‐free individuals. The association was stronger for anxiety disorders than for depression. The ORs for depression and anxiety disorders amongst both migraine and non‐migrainous sufferers increased with increasing headache frequency. Depression and anxiety disorders are associated with both migraine and non‐migrainous headache, and this association seems more dependent on headache frequency than diagnostic category.

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Metadata

Authors
Zwart, J. ‐., Dyb, G., Hagen, K., Ødegård, K. J., Dahl, A. A., Bovim, G., & Stovner, L. J.
Venue
European Journal of Neurology
Publisher
Wiley
Published
2003-03
Volume
10
Issue
2
Pages
147-152
ISSN
  • 1351-5101 (ISSN-L)
  • 1468-1331
OpenAlex
W1988932812
Cited by
383
References
38
FWCI
6.62
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Depression and anxiety disorders associated with headache frequency. The Nord‐Trøndelag Health Study. https://app.cochat.ai/papers/10.1046/j.1468-1331.2003.00551.x
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Zwart, J. ‐., Dyb, G., Hagen, K., Ødegård, K. J., Dahl, A. A., Bovim, G., & Stovner, L. J. (2003). Depression and anxiety disorders associated with headache frequency. The Nord‐Trøndelag Health Study. European Journal of Neurology. https://doi.org/10.1046/j.1468-1331.2003.00551.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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