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Vasoactive Peptide Levels in The Plasma of Young Migraine Patients With and Without Aura Assessed Both Interictally and Ictally
Abstract
We measured, by RIA methods, ictal and interictal levels of substance P (SP), calcitonin-gene related peptide (CGRP) and neurokinin A (NKA) in the plasma of 30 young migraine patients with aura (MPA) and 45 migraine patients without aura (MWA), and compared the results with those of 30 age-matched controls. There were no significant differences between the levels of these vasoactive peptides in the control group and the levels in both migraine groups studied in headache-free periods. An elevation of CGRP levels in plasma was found during attacks in MPA and, to a lesser extent, in MWA (p < 0.03 and p < 0.05, respectively). A significant increase in NKA levels was also demonstrated in the MPA and MWA groups (p < 0.02 and p < 0.04, respectively). These data suggest, although indirectly, that CGRP and NKA could be involved in the pathogenesis of migraine attacks in juvenile migraine patients.
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Citations
Cited by
Pathophysiology of migraine: a disorder of sensory processing
Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017) · Physiological Reviews · doi:10.1152/physrev.00034.2015 · Cited by 1,998
Calcitonin Gene-Related Peptide: Physiology and Pathophysiology
Russell, F. A., King, R., Smillie, S.-J., Kodji, X., & Brain, S. D. (2014) · Physiological Reviews · doi:10.1152/physrev.00034.2013 · Cited by 1,258
Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine
Cernuda-Morollón, E., Larrosa, D., Ramón, C., Vega, J., Martínez-Camblor, P., & Pascual, J. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a6cb72 · Cited by 468
Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist
Doods, H., Hallermayer, G., Wu, D., Entzeroth, M., Rudolf, K., Engel, W., & Eberlein, W. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703110 · Cited by 466
Pathophysiology of medication overuse headache: Insights and hypotheses from preclinical studies
Meng, I. D., Dodick, D., Ossipov, M. H., & Porreca, F. (2011) · Cephalalgia · doi:10.1177/0333102411402367 · Cited by 70
Metadata
- Authors
- Gallai, V., Sarchielli, P., Floridi, A., Franceschini, M., Codini, M., Glioti, G., Trequattrini, A., & Palumbo, R.
- Venue
- Cephalalgia
- Publisher
- SAGE Publishing
- Published
- 1995-10-01
- Volume
- 15
- Issue
- 5
- Pages
- 384-390
- ISSN
- 0333-1024 (ISSN-L)
- OpenAlex
- W2147917012
- Cited by
- 288
- References
- 0
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Vasoactive Peptide Levels in The Plasma of Young Migraine Patients With and Without Aura Assessed Both Interictally and Ictally. https://app.cochat.ai/papers/10.1046/j.1468-2982.1995.1505384.x
- The paper
- Gallai, V., Sarchielli, P., Floridi, A., Franceschini, M., Codini, M., Glioti, G., Trequattrini, A., & Palumbo, R. (1995). Vasoactive Peptide Levels in The Plasma of Young Migraine Patients With and Without Aura Assessed Both Interictally and Ictally. Cephalalgia. https://doi.org/10.1046/j.1468-2982.1995.1505384.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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