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Topiramate in the Treatment of Chronic Migraine
Open accessAbstract
The purpose of this study was to evaluate the efficacy of topiramate in the treatment of chronic migraine. This was a double-blind, randomized, placebo controlled, parallel-group study. Patients suffering from chronic migraine with analgesic overuse were randomly assigned in a 1 : 1 ratio to receive topiramate or placebo. Following a baseline phase of eight weeks, the study drug was titrated in 25-mg increments over one week to 50 mg daily. Titration phase was followed by a 8-week maintenance phase. Number of days with headache during a 28-day period was the efficacy variable. At baseline, there was no difference in the number of days with headache between patients treated with topiramate and those treated with placebo (mean ± SD: 20.9 ± 3.2 and 20.8 ± 3.2, respectively). During the last 4 week-maintenance phase, topiramate-treated patients experienced a significantly lower 28-day headache frequency in comparison to those treated with placebo (mean number of days with headache ± SD: 8.1 ± 8.1 vs. 20.6 ± 3.4, P < 0.0007). Topiramate at low doses proved to be an effective therapeutic approach to reduce headache frequency in patients with chronic migraine and analgesic overuse.
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“significant issues persist in patients who do not benefit from current drug treatments [54, 55]”
From Protocol and methods for testing the efficacy of well-being therapy in chronic migraine patients: a randomized controlled trial. (2018) · cites this paper as [54]
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Metadata
- Authors
- Silvestrini, M., Bartolini, M., Coccia, M., Baruffaldi, R., Taffi, R., & Provinciali, L.
- Affiliations
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Department of Neurological Sciences, University of Ancona, Ancona, Italy
- Corresponding author
- Silvestrini, M
- Venue
- Cephalalgia
- Publisher
- SAGE Publications
- Published
- 2003-10
- Volume
- 23
- Issue
- 8
- Pages
- 820-824
- ISSN
- 0333-1024 (ISSN-L)
- 1468-2982
- OpenAlex
- W2015197538
- Cited by
- 162
- References
- 23
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 9 · 2014: 9 · 2013: 7 · 2012: 9
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cephalalgia (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Health Sciences › Dentistry › Oral Surgery › Temporomandibular Joint Disorders
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- topiramate, chronic migraine, analgesic overuse, headache frequency, anticonvulsant prophylaxis, dose titration
- MeSH terms
- Topiramate, Adult, Analgesics, Chronic Disease, Double-Blind Method, Female, Fructose, Humans, Male, Middle Aged, Migraine Disorders, Multivariate Analysis, Confidence Intervals, Chi-Square Distribution, Odds Ratio
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