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Cortical Regulation of Subcortical Dopamine Release: Mediation via the Ventral Tegmental Area
Abstract
Abstract: In vivo microdialysis was used to determine the extent to which ionotropic glutamate receptors in the ventral tegmental area (VTA) regulate dopamine release in the nucleus accumbens. Coapplication of 2‐amino‐5‐phosphonopentanoic acid (AP5; 200 µ M) and 6‐cyano‐7‐nitroquinoxaline‐2,3‐dione (CNQX; 50 µ M) to the VTA via reverse dialysis decreased extracellular concentrations of dopamine in the nucleus accumbens by ∼30%. In accordance with previous results, electrical stimulation of the prefrontal cortex increased dopamine release by 60%. Application of AP5 and CNQX to the VTA during cortical stimulation blocked the effect of stimulation on dopamine release. These results indicate that ionotropic glutamate receptors in the VTA are critically involved in basal and evoked dopamine release in the nucleus accumbens and suggest that a glutamatergic projection from the prefrontal cortex regulates the activity of dopaminergic neurons in the VTA.
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Cited by
Depue, R. A., & Collins, P. F. (1999) · Behavioral and Brain Sciences · doi:10.1017/s0140525x99002046 · Cited by 2,046
Bymaster, F. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00346-9 · Cited by 1,123
Strafella, A. P., Paus, T., Barrett, J., & Dagher, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-15-j0003.2001 · Cited by 1,058
depue, R. A., & morrone-strupinsky, J. V. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000063 · Cited by 958
The role of excitatory amino acids in behavioral sensitization to psychomotor stimulants
Wolf, M. E. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00090-7 · Cited by 934
Metadata
- Authors
- Taber, M. T., Das, S., & Fibiger, H. C.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 1995-09
- Volume
- 65
- Issue
- 3
- Pages
- 1407-1410
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1999728406
- Cited by
- 253
- References
- 0
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Taber, M. T., Das, S., & Fibiger, H. C. (1995). Cortical Regulation of Subcortical Dopamine Release: Mediation via the Ventral Tegmental Area. Journal of Neurochemistry. https://doi.org/10.1046/j.1471-4159.1995.65031407.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
