Cited by 262Neuroscience and Neuropharmacology ResearchCancer, Hypoxia, and MetabolismNeuroprotection in Cerebral Ischemia

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Brain Lactate Is an Obligatory Aerobic Energy Substrate for Functional Recovery After Hypoxia: Further In Vitro Validation

Schurr, Avital, Payne, Ralphiel S., Miller, James J., Rigor, Benjamin M.·1997·Journal of Neurochemistry

DOI 10.1046/j.1471-4159.1997.69010423.x

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Abstract

This study used the rat hippocampal slice preparation and the monocarboxylate transporter inhibitor, alpha-cyano-4-hydroxycinnamate (4-CIN), to assess the obligatory role that lactate plays in fueling the recovery of synaptic function after hypoxia upon reoxygenation. At a concentration of 500 microM, 4-CIN blocked lactate-supported synaptic function in hippocampal slices under normoxic conditions in 15 min. The inhibitor had no effect on glucose-supported synaptic function. Of control hippocampal slices exposed to 10-min hypoxia, 77.8 +/- 6.8% recovered synaptic function after 30-min reoxygenation. Of slices supplemented with 500 microM 4-CIN, only 15 +/- 10.9% recovered synaptic function despite the large amount of lactate formed during the hypoxic period and the abundance of glucose present before, during, and after hypoxia. These results indicate that 4-CIN, when present during hypoxia and reoxygenation, blocks lactate transport from astrocytes, where the bulk of anaerobic lactate is formed, to neurons, where lactate is being utilized aerobically to support recovery of function after hypoxia. These results unequivocally validate that brain lactate is an obligatory aerobic energy substrate for posthypoxia recovery of function.

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Authors: Schurr, A., Payne, R. S., Miller, J. J., & Rigor, B. M.
Affiliations: University of Louisville (US)
Pediatrics and Genetics (US)
Corresponding author: Schurr, Avital
ORCID: Schurr, Avital
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 1997-07
Volume: 69
Issue: 1
Pages: 423-426
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1046/j.1471-4159.1997.69010423.x
OpenAlex: W1990158364
Cited by: 262
References: 0
Citations by year: 2026: 1 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 9 · 2014: 16 · 2013: 9 · 2012: 9
FWCI: 4.66
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1966 d)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Keywords: brain lactate, hypoxia, reoxygenation, monocarboxylate transporters, HCCA, hippocampus, astrocytes, lactate transport, aerobic metabolism, glucose utilization
MeSH terms: Animals, Brain Chemistry, Coumaric Acids, Electrophysiology, Energy Metabolism, Glucose, Hippocampus, Lactates, Male, Organ Culture Techniques, Synapses, Cell Hypoxia, Rats, Sprague-Dawley, Rats

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Brain Lactate Is an Obligatory Aerobic Energy Substrate for Functional Recovery After Hypoxia: Further In Vitro Validation

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