An ultra-high field magnetic resonance spectroscopy study of post exercise lactate, glutamate and glutamine change in the human brain.
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During strenuous exercise there is a progressive increase in lactate uptake and metabolism into the brain as workload and plasma lactate levels increase. Although it is now widely accepted that the brain can metabolize lactate, few studies have directly measured brain lactate following vigorous exercise. Here, we used ultra-high field magnetic resonance spectroscopy of the brain to obtain static measures of brain lactate, as well as brain glutamate and glutamine after vigorous exercise. The aims of our experiment were to (a) track the changes in brain lactate following recovery from exercise, and (b) to simultaneously measure the signals from brain glutamate and glutamine. The results of our experiment showed that vigorous exercise resulted in a significant increase in brain lactate. Furthermore, both glutamate and glutamine were successfully resolved, and as expected, although contrary to some previous reports, we did not observe any significant change in either amino acid after exercise. We did however observe a negative correlation between glutamate and a measure of fitness. These results support the hypothesis that peripherally derived lactate is taken up by the brain when available. Our data additionally highlight the potential of ultra-high field MRS as a non-invasive way of measuring multiple brain metabolite changes with exercise.
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Multimodal imaging such as MRI with MRS can assess the functional relevance of volumetric alterations that is not possible using one modality alone.
“This analysis and others (Dennis et al., 2015) illustrate the utility of using multimodal imaging such as MRI with MRS to assess the functional relevance of volumetric alterations that is not possible using one modality alone.”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Dennis et al., 2015
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“This analysis and others (Dennis et al., 2015) illustrate the utility of using multimodal imaging such as MRI with MRS to assess the functional relevance of volumetric alterations that is not possible using one modality alone.”
- Authors
- Dennis, A., Thomas, A. G., Rawlings, N. B., Near, J., Nichols, T. E., Clare, S., Johansen-Berg, H., & Stagg, C. J.
- Affiliations
- University of Oxford (GB)
- National Institutes of Health (US)
- Douglas Mental Health University Institute (CA)
- University of Warwick (GB)
- Corresponding author
- Dennis, Andrea
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2015-12-17
- Volume
- 6
- Pages
- 351-351
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC4681779
- OpenAlex
- W2238040334
- Cited by
- 43
- References
- 69
- Citations by year
- 2026: 6 · 2025: 3 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 5 · 2016: 2
- FWCI
- 2.70
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship@McGill (McGill) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship@McGill (McGill) (submittedVersion, cc-by)
- Funders
- Wellcome Trust (102584, 090955, 100309/A/12/Z, 102584/Z/13/Z)
- National Institute for Health and Care Research
- University of Oxford
- National Institute of Mental Health
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- brain lactate, brain glutamate, brain glutamine, physical activity, post-exercise recovery, exercise fitness, amino acid metabolism
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